袁永新.赢创德固赛在农药剂型SC,OD,EW研发新进展

赢创德固赛在农药剂型SC,OD,EW研发新进展

SC,OD,EWformulation

developmentEvonikDegussa,Shanghai赢创德固赛（中国）投资有限公司袁永新胡圣豪20100816Page|2

solidformulation固体制剂SG，WP，SP，WDG

liquidformulation液体制剂SL，ME，EC，EW，SC，CSFormulation

typeandtreand

制剂类型及发展方向Page|3Ratioofformulationinchina

国内剂型比例制剂类型及发展方向EC乳油26%WP可湿性粉剂

10%SC悬浮剂16%SL水剂19%WDG水分散粒剂

12%Others其它12%EW水乳剂5%Page|4Suspensionconcentration(水悬浮剂）SCTGismilledfinelyandsuspendedinthewaterwithdispersingagent,wettingagent,thickner,adjuvant是将固体原药磨细以后，悬浮于含有分散剂，润湿剂，增稠剂，增效剂的水中。Advantages:Nosolvent没有溶剂。Cancontainhighconcentrationsofai

高含量。Easytomeasureandmix容易称量混合。Compatiblewithaqueousconcentrates与水剂型制剂兼容。Disadvantages:Difficulttoproducesuccessfully研发难度大。Cansettleoutinstorage贮存中沉淀。Sensitivetofreezing不耐冻。Sensitivetoaipurityandpolymorphicform对原药杂质和晶体免感。Page|5Suspensionconcentration

水悬浮剂ComponentTypicalAmount%w/wActiveIngredient（原药）<80Wetter（润湿剂)1-2Dispersant(分散剂）3-6Antifoam（消泡剂）<0.5Antifreeze（防冻剂）5-20Antisettlingagent（抗沉降剂）0.1–2Biocide（防腐剂）0-0.2Water（水）TovolumePage|6Dispersants

分散剂Dispersantscangivestericandelectrostaticstabilizationoffinesolidparticlesinwater分散剂可以通过空间位阻或者静电作用将细小颗粒悬浮在水中。

Dispersantscanstoptheprocessofaggregationandcrystallation

分散剂可以防止粒子的聚合和重结晶（奥式熟化）Dispersantscanreducethemillingviscosity分散剂可以降低研磨粘度Page|7Techincal

probleminSCdevelopment

SC研发中的技术难题Viscosityincreaseinmilling研磨时粘度增大SolutionAddmoredispersants增加更多的分散剂Changedispersants改变分散剂Usethecombinationofdifferentsortsofdispersants使用不同种类的分散剂组合Page|8Techincal

probleminSCdevelopment

SC研发中的技术难题Foaminmilling研磨中泡沫多

Solution解决方案Changeantifoam改变消泡剂changewetter改变润湿剂Reducethewetter减少润湿剂Changedispersants改变分散剂Page|9Technical

probleminSCdevelopment

SC研发中的技术难题Particle

increaseinstorage

粒径在贮存中增加Aggrecationofparticle

粒径絮凝

Solution解决方案Changethe

dispersants

改变分散剂Addmoredispersants增加分散剂用量Use

combinationofdispersants使用分散剂组合Add

some

structure

agent加些结构剂Page|10Fungicidealone单用杀菌剂Pesticidedropletonsurfaceofleaf喷雾液呈水珠状，不能润湿菌丝Techincal

probleminSCdevelopment

SC研发中的技术难题Particle

increaseinstorage

在贮存中粒径增大Crystallationofparticle

粒径的重结晶Solution解决方案Use

combinationofdsiperants使用分散剂组合Use

dispersants

withhighCMC使用具有高CMC的分散剂Use

comb

polymeric

surfactant

使用梳妆聚合物分散剂Add

some

inogranic

salt

加一些无机盐Add

some

water

solublepolymerwithhighmoleculer

weight

加水溶性高分子量高聚物Page|11

ImidaclopridSC600formulation

吡虫啉产品介绍具有时代特质的划时代杀虫剂-吡虫啉1.结构独特，高效，低毒，低残留的特异性烟碱类杀虫剂2.杀虫镨广，适用作物多，用量少，持久期长，应用安全，环境友好。3.作用机理；胃毒，触杀，内吸应用现状及前景仍将是主要应用的杀虫剂合理的剂型选择很重要水悬浮剂水分散粒剂Page|12

ImidaclopridSC600formulation

吡虫啉600g/L配方组成GuidelineFormulationImidacloprid

WaterPGBREAK-THRU®DA646BREAK-THRU®DA675ThickenerBiocide600g/L吡虫啉SC600吡虫啉研磨相入水效果Page|13SCStabilityTestUsing

Lumifuge

悬浮剂稳定性的评测方法Unstable→StablewithBREAK-THRUPage|14

ImidaclopridSC600formulation

吡虫啉600g/L配方评价Item项目Suspensibility

悬浮率Particlesize粒径(D50)Viscosity粘度Separationandsediment分层和沉淀RT

98%

5.8450noseparationnosedimentation（不析水不沉降）HT98%6.0380LittleseparationNosedimentation（少量析水，没有沉淀）Analysistheformulationbystoragein54Cfor28days热贮28天54C下的情况Page|15Particlesizeanalysis

ImidaclopridSC600formulation

吡虫啉600g/LPage|16Particlesizeanalysis

ImidaclopridSC600formulation

吡虫啉600g/LParticlephotoinmicroscope显微镜中粒径变化

ImidaclopridSC600

吡虫啉600g/L粒径变化起始54C热贮28D20%PyridabenSC

formulation

20%哒螨灵配方组成GuidelineFormulationPyridaben

PGBREAK-THRU®DA646BREAK-THRU®DA655ThickenerBiocideWaterPage|19BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/赢创德固赛公司SC配方助剂产品BreakThruDA646BreakThruDA655BreakThruDA675BreakThruDA752WBreakThruAF9903Tego

Antifoam32HPage|20BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/赢创德固赛公司SC配方助剂产品BreakThruDA646Specialpolyether

（特殊的聚醚分散剂）

Reducingofmillingtime（减少研磨时间）PreventingOstwaldripeningandagglomeration（防止奥式熟化和粒子聚集）

Actingaswetting

agent（具有润湿作用）Page|21BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/赢创德固赛公司SC配方助剂产品BreakThruDA655SpecialPolyetherphosphate（特殊的聚醚磷酸酯）Can

useinOD,SC,EW.（可以在OD，SC，EW中使用）BreakThruDA675apolymerdispersants（共聚物分散剂）ExtremelyefficientdispersantwhichyieldshighloadingSCandlowerpre-millviscosities（高效分散剂，可以制备高含量，降低研磨粘度）Betterstability-irreversiblyadsorbsontotoxicantsurface（很好吸附作用，增加制剂稳定性）Mustbeusedinconjunctionwithawetter（必须和润湿剂联用）Page|22BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/赢创德固赛公司SC配方助剂产品BREAK-THRUAF9903TEGOANTIFOAM32H极好的水基消泡剂。烷基糖苷烷基糖苷加32HPage|23赢创德固赛成功开发的SC产品名录600克/升吡虫啉SC350克/升吡虫啉SC200克/升吡虫啉SC50%百菌清SC430g/L

戊唑醇SC500g/L多菌灵SC250g/L硫磺SC20%

哒螨灵SC500g/L丁醚脲SC200g/L氟虫腈SC2,4D/毒草定SC代森锰锌SC甲氧基丙烯酸酯SC硼SCEmulsioninWater

水乳剂EWTGishighshearedfinelyandsuspendedinthewaterwithdispersingagent,thickner是将液体剪切剪细以后，悬浮于含有分散剂，增稠剂的水中Advantages（优点）:Minimalskinandeyeirritation（极低的皮肤和眼睛刺激）Lessornosolvent（很少或者没有溶剂）Minimaltoxicity（低毒）Lowornoflammability（极低起燃性）Disadvantages（缺点）:Maybetemperaturesensitive（对温度敏感）Page|25EW

水乳剂ComponentTypicalAmount%w/wActiveIngredient（原药）<50Solvent（溶剂)0-20Dispersant(分散剂）1.5-10Antifoam（消泡剂）<0.5Antifreeze（防冻剂）5-20Antisettlingagent（抗沉降剂）0–2Biocide（防腐剂）0-0.2Water（水）TovolumePage|26TechnicinEWformulationEW的技术关键GoodcombinationofhighHLBSurfactantandlowHLBsurfactant合理使用高HLB值和低HLB值的分散剂组合Selectgoodthickner合理选用增稠剂Selectsuitablesolvent合理选用溶剂Page|27Chlorpyrifos40％Evonik‘sEWformulation

毒死蜱40%

EW

Chlorpyrifos40%Solvesso200BREAK-THRU®DA655BREAK-THRU®DA646PGAF9903thicknerWaterPage|28粒径变化Chlorpyrifos40％Evonik‘sEWformulation

毒死蜱40%

EW

起始54C热贮14DPage|29BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/赢创德固赛公司EW配方助剂BreakThruDA646BreakThruDA655BreakThruDA675BreakThruAF9903Tego

antifoam32HBreakThruDA646和BreakThruDA655搭配使用于各种水乳剂配方中。Page|30赢创德固赛成功开发产品名录400克/升毒死蜱EW500克/升丙草胺EW5.7%氟氯氰菊酯EW5.0%高效氯氟氰菊酯

EW

5.0%阿维菌素EW100克/升氯氰菊酯EW25克/升溴氰菊酯EWPage|31ODTGismilledfinelyandsuspendedinoilwithdispersingagent,emulsifier,antisettlingagent.是将固体原药磨细以后，悬浮于含有分散剂，乳化剂，增稠剂的油中。ComponentTypicalAmount%w/w0ActiveIngredient（原药）<50Emulsifier（乳化剂)10-15Dispersant(分散剂）2-6Antifoam（消泡剂）<0.5Antisettlingagent（抗沉降剂）0.1–4Antioxide（抗氧化剂剂）0-1Oil（油）TovolumePage|32Dispersantsandemulsifiermayinterfereeachother,agoodcombinationisveryimportantforOD分散剂和乳化剂可能互相影响，因此需要好的分散剂，乳化剂组合。ChangetheHLBtogetagoodemulsion调节HLB以达到好乳化效果Usesuitableantisettlingagent

togetsuitableformulation选择合适的增稠剂TechincalinODformulation

油悬浮剂技术Page|33SulfonylureaODFormulationwithBREAK-THRU®OE441

油悬浮剂OD：磺酰脲类油悬浮剂添加博力通OE441磺酰脲类农药水解稳定性低，大多以WDG剂型为主SulfonylureaistypicallyformulatedasWDGduetohydrolysis使用时常用桶混助剂提高渗透内吸能力Tankmixadjuvantsaddedtoimproveuptakeofa.i.(activeingredient)

液体制剂使用方便，但面临的难题包括：Liquidformulationsaremoreconvenient,butchallenging合适的乳化剂Emulsifier合适的分散剂Dispersant合适的润湿剂Wettingagent制剂的分散稳定性PhysicalStabilityofDispersion化学稳定不水解ChemicalstabilityofSulfonylurea防治药效BiologicalperformancePage|34ExampleofanODformulation

basedonBREAK-THRU®

Products

以博力通助剂开发的油悬浮剂－烟嘧磺隆4％ODGuideline

Nicosulfuron(40g/l)ODFormulation:烟嘧磺隆(40g/l)OD配方

Material

wt.%Active4.5SoybeanOil 68.5（BREAK-THRU®OE441） 5BREAK-THRU®DA6522.8BREAK-THRU®V2012.2Thickener3相差显微镜Phasecontrast

microscope放大比例10倍，10times

magnified德固赛油悬浮剂的物理状态:

细小，均一的颗粒

通过加速贮存检验

@54ºC:

粘度=28mPas@25ºCPage|35Formulation

Stability

byHPLCAnalysis

配方稳定性通过了HPLC检验

化学降解检测对烟嘧磺隆很重要，我们的配方通过了稳定性的检测。Calibration1-40µg/mlPage|36Greenhouse

Results

for

Nicosulfuron

Formulations(10ga.i./ha)with

MeadowGrass(Poa

pratensis)

温室验证对草地早熟禾的药效药效(%)我们产品跟市场标杆产品的药效比较Page|37BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/博力通配方DA系列产品BreakThruDA652BreakThruDA655BreakThruDA700BreakThruEMV20BreakThruAF9902BreakThruOE441

Page|38BREAK-THRU®

ProductDASeries

for

In-Can

Formulations/博力通配方DA系列产品BreakThruDA652是脂肪醇衍生物很好的油悬浮剂分散剂，可以极大地降低油悬浮剂的粘度，控制油悬浮剂的析油，控制粒径的增长。BreakThruEMV20

Vegetable-basednonionicemulsifier

植物源非离子型乳化剂Excellentecological,toxicologicalanddermatologicalbehavior

低毒、环境安全Exceptionalemulsifyingpropertiesforvegetableoilse.g.seedoils

对植物油乳化性能特别优异Page|39赢创德固赛成功开发产品名录烟嘧磺隆40克/升OD烟嘧磺隆+莠去津23%

ODDesigned

specific

adjuvant

actions

特效增效剂ActionS240S233VibrantOE441OE444G850Anti-Foam