【实用资料】乙酸肉桂酯的合成PPT

乙酸肉桂酯的合成乙酸肉桂酯的合成ContentsIntroduction1Experimental2Results＆discussion34ConclusionsL-LPTCItinvolvesthe

reactionofanionicreactant

fromaqueousphasewiththereactantinorganicphasebyaphasetransfercatalystS-LTPCItinvolves

thereactionbetweenthesolidnucleophilewiththeotherreactant

intheorganicliquidphasePTCphasetransfercatalysisItinvolvesthereactionofanionicreactantfromaqueousphasewiththereactantinorganicphasebyaphaseaddarequiredsurfaceareaandmasstransferlimitations.Results＆discussionExperimentalreactiontemperaturephasebyaphaserateexpressionrateexpressioninthefollowingstudies.‘‘omegaphase”enhancetheItinvolvesthereactionofanionicreactantfromaqueousphasewiththereactantinorganicraisedto90°CwithExperimentalreached90°CL-LPTC

eliminatesthe

needofusingaqueousphasethuseliminatestheseparationproblems

andeasyrecoveryofthecatalystenhancestheproductselectivitybyavoidingthesidereactionslowerselectivityandothersidereactionssynthesis

offineandspecialtychemicalsseparationand

purifyingthefinalproductComparedwithL-LPTCandL-SPTCL-SPTCthecarboxylicacidsshowslessreactivity‘‘omegaphase”enhancethesolubilizationofthesolidandformationofthecatalyticintermediatewefocusoureffortsonstudyingthekineticsandfactorsaffectingthesynthesisofcinnamylacetate（乙酸肉桂酯）fromcinnamylbromide（肉桂酸溴）andsodiumacetate（乙酸钠）byS–LPTC.

sodiumacetate(0.025mol)，cinnamylbromide(0.02mol)，n-dodecaneadd

chlorobenzeneto

50mLandthetemperature

was

raisedto90°CwithconstantstirringProductaddarequiredamountofphasetransfercatalystwhenthe

temperaturereached90°C

Atpresettimes,thestirrer

wasturne

offtemporarily,0.5mloforganicsolutionwas

pipettedoutanalyzedonagaschromatographusingSE-30Column.3.Results＆discussion7factorstypeofcatalystspeedofagitationreactiontemperaturewateradditionsizeofsodiumacetatecatalystloadingconcentrationofreactantInordertooptimizethereactionconditions,theesterificationreactionwascarriedoutbyvaryingfactorsasfollow:

3.Results＆discussion3.1EffectofagitationspeedTheinterfacialmasstransferresistancebetweenthesolidsurfaceandorganicphaseisnegligiblewhentheagitationspeedisabove600rpm.Inthiscontext,agitationspeedwasfixedat600rpmforallfurtherexperiments.

3.Results＆discussion3.2EffectofalkylchainlengthofthecatalystHenceTBABischosenasthephasetransfercatalystinthefollowingstudies.3.Results＆discussion3.3effectofreactiontemperatureAlthoughahightemperatureusuallyfavorsthesidereactions,nosideproductswerefoundat95°Cinthisstudy.3.Results＆discussion3.4EffectofcatalystloadingSincereasonableconversionsareobservedatthecatalystloadingof1.6g,thefurtherexperimentsarecarriedoutatthecatalystloadingof1.6g.ItinvolvesthereactionofanionicreactantfromaqueousphasewiththereactantinorganicTheinterfacialmasstransferresistancebetweenthesolidsurfaceandorganicrateexpression5andremainedalmostconstantthereafter.Inthiscontext,agitationspeedwasfixedat600rpmforallfurtherexperiments.solubilizationofthesolidandformationofthecatalyticintermediatephasetransfer6、Thereactionresultsobtainedat80–95Cwellfittedintothepseudo-firstorderrateequation.phaseisnegligiblewhentheagitationspeedisabove600rpm.Results＆discussion2、Usingamoderateamount(1.Results＆discussiontypeofcatalyst6g)oftetran-butylammoniumbromideasthecatalystat95°C.

3.Results＆discussion3.5EffectofmoleratioTheconversionofcinnamylbromideincreasedwiththeincreaseofmoleratioofcinnamylbromidetosodiumacetatefrom1:1to1:1.5andremainedalmostconstantthereafter.

3.Results＆discussion3.6EffectofwateradditionTheoptimalusageofwaterinthepresentstudywasobservedtobe4ml.

3.Results＆discussion3.7EffectofpaticalsizeofsodiumacetateLowreactivityofthesodiumacetategranulesmaybeattributedtotheirlowsurfaceareaandmasstransferlimitations.3.Results＆discussionrateexpression——(1)3.Results＆discussionrateexpression——（2）3.Results＆discussionrateexpressionk=k'Cc——（3)1、Thesolid–liquidphasetransfercatalysiswassuccessfullyemployedforthesynthesisofcinnamylacetatefromtheesterificationofsodiumacetatewithcinnamylbromidebyusingTBABasthecatalyst.2、Usingamoderateamount(1.6g)oftetran-butylammoniumbromideasthecatalystat95°C.3、Thesolid–liquidinterfacialmasstransferresistanceisnegligibleatagitationspeedabove600rpm.4、Thecatalystwithlongeralkylchainlengthgivesbetterperformance,however,itwillmoreeasilydissolvedintheorganicphaseandhenceismoredifficulttoberemovedandreusedafterthereaction.5、Adding1–8mlofwaterimprove