Biperiden-hydrochloride-Standard-KL-373-hydrochloride-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEBiperidenhydrochloride(Standard)Cat.No.:HY-13204RCASNo.:1235-82-1Synonyms:KL373hydrochloride(Standard)分子式:C₂₁H₃₀ClNO分子量:347.92作用靶点:mAChR作用通路:GPCR/GProtein;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:20mg/mL(57.48mM;Needultrasonic)H2O:5mg/mL(14.37mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8742mL14.3711mL28.7422mL5mM0.5748mL2.8742mL5.7484mL10mM0.2874mL1.4371mL2.8742mLBIOLOGICALACTIVITY生物活性Biperiden(hydrochloride)(Standard)是Biperiden(hydrochloride)的分析标准品。本产品用于研究及分析应用。Biperiden(KL373)hydrochloride是一种非选择性毒蕈碱受体(muscarinicreceptor)拮抗剂，可以与M1毒蕈碱受体竞争性结合，从而抑制乙酰胆碱(acetylcholine)并增强中枢神经系统中多巴胺信号传导。Biperidenhydrochloride可用于帕金森病以及其他相关精神疾病的研究。REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEPehlC,etal.Effectsoftwoanticholinergicdrugs,trospiumchlorideandbiperiden,onmotilityandevokedpotentialsoftheoesophagus.AlimentPharmacolTher.1998Oct;12(10)KornhuberJ,etal.Identificationofnovelfunctionalinhibitorsofacidsphingomyelinase.PLoSOne.2011;6(8)MyhrerT,etal.Antiparkinsondrugsusedasprophylacticsfornerveagents:studiesofcognitivesideeffectsinrats.PharmacolBiochemBehav.2008Jun;89(4):633-8.LeonieKonczalla，etal.BiperidenandmepazineeffectivelyinhibitMALT1activityandtumorgrowthinpancreaticcancer.IntJCancer.2020Mar15;146(6):1618-1630.SimoneBittencourt,etal.Modificationofthenaturalprogressionofepileptogenesisbymeansofbiperideninthepilocarpinemodelofepilepsy.EpilepsyRes.2017Dec;138:88-97.doi:10.1016/j.eplepsyres.2017.10.019.Epub2017Oct29.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379