Imipramine-hydrochloride-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEImipraminehydrochloride(Standard)Cat.No.:HY-B1490RCASNo.:113-52-0分子式:C₁₉H₂₅ClN₂分子量:316.87作用靶点:SerotoninTransporter;Apoptosis;Autophagy作用通路:NeuronalSignaling;Apoptosis;Autophagy储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:≥100mg/mL(315.59mM)H2O:62.5mg/mL(197.24mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM3.1559mL15.7793mL31.5587mL5mM0.6312mL3.1559mL6.3117mL10mM0.3156mL1.5779mL3.1559mLBIOLOGICALACTIVITY生物活性Imipramine(hydrochloride)(Standard)是Imipramine(hydrochloride)的分析标准品。本产品用于研究及分析应用。Imipraminehydrochloride是一种具有口服活性的叔胺类三环抗抑郁药。Imipraminehydrochloride是一种具有抗肿瘤活性的Fascin1抑制剂。Imipraminehydrochloride也抑制5-羟色胺转运体(serotonintransporter)，其IC50值为32nM。Imipraminehydrochloride刺激U-87MG胶质瘤细胞自噬（autophagy），诱导HL-60细胞凋亡（apoptosis）。Imipraminehydrochloride具有神经保护和免疫调节作用。IC50&TargetFascin1,SerotoninAutophagy,Apoptosis[1][2][3][5]1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEIC50:32nM(humanplacentalserotonintransporter)[5]REFERENCESAlburquerque-GonzálezB,etal.NewroleoftheantidepressantimipramineasaFascin1inhibitorincolorectalcancercells.ExpMolMed.2020Feb;52(2):281-292.JeonSH,etal.ThetricyclicantidepressantimipramineinducesautophagiccelldeathinU-87MGgliomacells.BiochemBiophysResCommun.2011Sep23;413(2):311-7.XiaZ,etal.Theantidepressantsimipramine,clomipramine,andcitalopraminduceapoptosisinhumanacutemyeloidleukemiaHL-60cellsviacaspase-3activation.JBiochemMolToxicol.1999;13(6):338-47.RamirezK,etal.Imipramineattenuatesneuroinflammatorysignalingandreversesstress-inducedsocialavoidance.BrainBehavImmun.2015May;46:212-20.BalkovetzDF,etal.Evidenceforanimipramine-sensitiveserotonintransporterinhumanplacentalbrush-bordermembranes.JBiolChem.1989Feb5;264(4):2195-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel