AlF-NOTA-c-d-VAP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAlF-NOTA-c-d-VAPCat.No.:HY-D2334分⼦式:C₅₁H₈₃AlFN₁₇O₁₉S分⼦量:1316.35作⽤靶点:HSP作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性AlF-NOTA-c-d-VAP⼀种肽正电⼦发射断层扫描(PET)探针，⽤于GRP78的靶向肿瘤成像。AlF-NOTA-c-d-VAP在体外和体内表现出⾼稳定性。体内研究Micro-PETimaging,pharmacokineticanalysis,andbiodistributionstudieswerecarriedoutintumor-bearingmicetoevaluatetheprobe’sperformance.AlF-NOTA-c-DVAPisradiolabeledinjust25minwithahighyieldof51%,aradiochemicalpurityof99%,andmolaractivitywithintherangeof20-50GBq/μmol.DynamicPETimagingofAlF-NOTA-c-DVAPintumorsshowedrapiduptakeandsustainedretention,withminimalbackgrounduptake.Biodistributionstudiesrevealedrapidbloodclearanceandexcretionthroughthekidneysfollowingasingle-compartmentreversiblemetabolicmodel[1].InPETimaging,theT/MratiosforA549tumors(highGRP78expression),MDA-MB-231tumors(mediumexpression),andHepG2tumors(lowexpression)at60minpostintravenousinjectionare10.48%,6.25%,and3.15%ID/g,respectively[1].REFERENCES[1].JiawenHuang,etal.SynthesisandEvaluationof[18F]AlF-NOTA-c-DVAP:ANovelPETProbeforImagingGRP78inCancer.MolPharm.2024Mar30.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: