Debutyldronedarone-d7-hydrochloride-SR35021-d-sub-7-sub-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEDebutyldronedarone-d7hydrochlorideCat.No.:HY-12753ASSynonyms:SR35021-d7hydrochloride分子式:C₂₇H₃₀D₇ClN₂O₅S分子量:544.15作用靶点:ThyroidHormoneReceptor;Isotope-LabeledCompounds作用通路:VitaminDRelated/NuclearReceptor;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Debutyldronedarone-d7hydrochloride是氘代标记的Debutyldronedaronehydrochloride(HY-12753A)。Debutyldronedarone(SR35021)hydrochloride是Dronedarone的主要代谢物，是一种选择性的甲状腺激素受体α1(TRα1)抑制剂。Debutyldronedaronehydrochloride抑制T3与TRα1和TRβ1的结合，抑制率分别为77%和25%。Debutyldronedaronehydrochloride可用于心律失常的研究[1]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCESVanBeerenHC,etal.Droneraroneactsasaselectiveinhibitorof3,5,3'-triiodothyroninebindingtothyroidhormonereceptor-alpha1:invitroandinvivoevidence.Endocrinology.2003Feb;144(2):552-8.RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: