BMP-agonist-2-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBMPagonist2Cat.No.:HY-158203CASNo.:1438900-88-9分⼦式:C₁₆H₁₉NO₅分⼦量:305.33作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:100mg/mL(327.51mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.2751mL16.3757mL32.7515mL5mM0.6550mL3.2751mL6.5503mL10mM0.3275mL1.6376mL3.2751mL体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(8.19mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(8.19mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性BMPagonist2(derivativeI-9)⼀种有效的⾻诱导细胞因⼦。BMPagonist2通过增加成⾻细胞的⽐例和活性，促进⾻组织的⽣成。BMPagonist2通过BMP2-ATF4信号轴促进成⾻细胞的增殖和分化，其中ATF4⼀个与成⾻细胞分化和⾻形成密切相关的转录因⼦。BMPagonist2可⽤于⽼年性⾻质疏松症(SOP)的研究[1]。REFERENCES[1].ZhouZ,etal.Efficacy,Mechanism,andStructure–ActivityRelationshipof6-MethoxyBenzofuranDerivativesasaUsefulToolforSenileOsteoporosis[J].JournalofMedicinalChemistry,2023,66(3):1742-1760.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: