nor-NOHA-Nω-Hydroxy-nor-L-arginine-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEnor-NOHACat.No.:HY-112885CASNo.:189302-40-7Synonyms:Nω-Hydroxy-nor-L-arginine分⼦式:C₅H₁₂N₄O₃分⼦量:176.17作⽤靶点:Apoptosis;Arginase作⽤通路:Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验H2O:250mg/mL(1419.08mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM5.6763mL28.3817mL56.7634mL5mM1.1353mL5.6763mL11.3527mL10mM0.5676mL2.8382mL5.6763mLBIOLOGICALACTIVITY⽣物活性nor-NOHA⼀种选择性的，可逆的arginase抑制剂。nor-NOHA在缺氧条件诱导ARG2表达细胞的凋亡(apoptosis)。nor-NOHA有抗⽩⾎病的活性。nor-NOHA可⽤于研究内⽪功能障碍、免疫抑制及代谢[1][2]。体外研究nor-NOHA(0.1-1mM,72h)inducesapoptosisinadose-dependentmannerunderhypoxia(1.5%O2)inK562cells[1].nor-NOHA(1mM,72h)attenuateshypoxia-mediatedresistancetowardsimatinibinK562orKCL22cells[1].体内研究nor-NOHA(100mg/kg,i.v.,oncetime)inducesasignificantreductionofinfarctsizeinmaleSprague-Dawley1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemErats[2].nor-NOHA(100mg/kg,i.v.,oncetime)increasesplasmacitrullineandnitritelevelsanddecreasestheornithineplasmalevelsinmaleSprague-Dawleyrats[2].户使⽤本产品发表的科研⽂献•FrontCellDevBiol.2021Dec23;9:741911.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].NgKP,etal.ThearginaseinhibitorNω-hydroxy-nor-arginine(nor-NOHA)inducesapoptosisinleukemiccellsspecificallyunderhypoxicconditionsbutCRISPR/Cas9excludesarginase2(ARG2)asthefunctionaltarget.PLoSOne.2018Oct11;13(10):e0205254.[2].JungC,etal.Arginaseinhibitionmediatescardioprotectionduringischaemia-reperfusion.CardiovascRes.2010Jan1;85(1):147-54.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379