免疫球蛋白特性王利沙Immunoglobulinproperties讲解

免疫球蛋白特性主讲老师：王利沙ImmunoglobulinpropertiesWeifangNursingVocationalCollege潍坊护理职业学院根据重链C区结构的差别，将Ig分为五类，即IgG、IgA、IgM、IgD、IgE。AccordingtothestructuredifferenceofheavychainCregion,Igcanbedividedintofivecategories,namelyIgG,IgA,IgM,IgDandIgE.免疫球蛋白Immunoglobulin各类免疫球蛋白的特性Characteristicsofvariousimmunoglobulins

半衰期长，约23天Thehalf-lifeislong,about23days.

机体再次免疫应答的主要抗体

Themainantibodyofthebody'sre-immuneresponse.IgG

单体形式，含量高Monomerform,highcontent

具有抗菌、抗病毒、抗毒素作用

Ithasantibacterial,antiviralandantitoxineffects.

IgG是唯一能通过胎盘的抗体

IgGistheonlyantibodythatcancrosstheplacenta.IgM机体感染后在血清中最早出现的抗体，脐带血中IgM升高提示胎儿有宫内感染；Thefirstantibodyappearedintheserumafterinfection,andtheincreaseofIgMinumbilicalcordbloodindicatedintrauterineinfectionofthefetus.个体发育中最早合成和分泌的抗体；Theearliestsynthesizedandsecretedantibodyinindividualdevelopment.半衰期短，约5天。Thehalf-lifeisshort,about5days.五聚体；

Pentamer分子量最大的免疫球蛋白；Thehighestmolecularweightimmunoglobulin.各类免疫球蛋白的特性Characteristicsofvariousimmunoglobulins分为血清型和分泌型（sIgA）两种Twotypes:serotypeandsecretorytype(sIgA)血清型为单体，分泌型为二聚体Theserumtypeismonomerandthesecretiontypeisdimer.机体局部黏膜抗感染的重要因素；Theimportantfactoroflocalmucosalanti-infection.初乳中含有sIgA，故提倡母乳喂养；ColostrumcontainssIgA,sobreastfeedingisrecommended.IgA

各类免疫球蛋白的特性Characteristicsofvariousimmunoglobulins单体形式Monomericform.各类免疫球蛋白的特性CharacteristicsofvariousimmunoglobulinsIgD含量极低，为B细胞膜上的受体Extremelylowcontent,itisareceptorontheBcellmembrane.半衰期短，仅为3天Ithasashorthalf-lifeofonly3days.血清IgD功能尚未清楚。ThefunctionofserumIgDisunclear.血清中含量最少

Theleastamountwasfoundinserum.过敏性疾病或寄生虫感染时，特异性IgE含量显著增高。

Inallergicdiseasesorparasiticinfections,thespecificIgE

contentissignificantlyincreased.各类免疫球蛋白的特性Characteristicsofvariousimmunogl