Piperacillin-hydrate-Pipracil-hydrate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPiperacillinhydrateCat.No.:HY-B1923ACASNo.:66258-76-2Synonyms:Pipracilhydrate分⼦式:C₂₃H₂₉N₅O₈S分⼦量:535.57作⽤靶点:Antibiotic;Bacterial;Beta-lactamase;Penicillin-bindingprotein(PBP)作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Piperacillinhydrate⼀种半合成的⼴谱β-内酰胺类抗⽣素，通过霉素结合蛋⽩具有对⾰兰性和部分⾰兰阳性较强的杀活性。Piperacillinhydrate最常与β-内酰胺酶抑制剂Tazobactam(HY-B1418)联合使⽤[1][2][3]。体外研究Piperacillin(12.5μg/mL,24h)hydrateinhibits92%ofisolatesofPseudomonasaeruginosa,82%ofSerratiamarcescens,73%ofEscherichiacoli,61%ofKlebsiellaspp,and42%ofEnterobacterspp,mostProteusspp.areextremelysusceptible.Piperacillinhydratefailstoinhibitthegrowthofgram-negativebacilliwhenlargeinoculawereused(minimuminhibitoryconcentration>25μg/mL)[2].体内研究Piperacillin(100mg/kg,i.v.,4timesaday,5d)hydrateincombinationwithTazobactam(HY-B1418)(12.5mg/kg,i.v.,4timesaday,5d)prolongssurvivalinmicewithlowinoculumofK.pneumoniae[3].AnimalModel:BALB/clowinoculummodelofK.pneumoniae,KEN-11strain[3].Dosage:100mg/kgAdministration:Intravenousinjection(i.v.),4timesaday,5d,incombinationwithTazobactam(12.5mg/kg,i.v.,4timesaday,5d)Result:Enabledallmicesurvivedwhereasallcontrolmicediedby5d,decreasedthenumberofbacteriainlungscomparedwithcontrolgroup.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEObservednobacteriainthebloodofmostmice(exceptfortwomiceattheearlyphase)whilebacteriawereobservedinthebloodofcontrolgroup.Observedfewinflammatorycellsinthealveoliwhereasaninfluxofnumerousinflammatorycellswereobservedinthecontrolgroup.户使⽤本产品发表的科研⽂献•NatCommun.2022Mar2;13(1):1116.•PLoSPathog.2024Dec31;20(12):e1012783.•AntimicrobAgentsChemother.2023May18;e0160322.•MicrobiolSpectr.2023Apr24;e0069223.•MicrobiolSpectr.2022Dec8;e0303822.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].FuKP,etal.Piperacillin,anewpenicillinactiveagainstmanybacteriaresistanttootherpenicillins.AntimicrobAgentsChemother.1978,13(3):358-67.[2].BodeyGP,etal.Piperacillin:InVitroEvaluation.AntimicrobAgentsChemother.1978,14(1):78-87.[3].HaradaY,etal.Invitroandinvivoactivitiesofpiperacillin-tazobactamandmeropenematdifferentinoculumsizesofESBL-producingKlebsiellapneumoniae.ClinMicrobiolInfect.2014,20(11):O831-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplication