Hericenone-C-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEHericenoneCCat.No.:HY-N16500CASNo.:137592-03-1分子式:C₃₅H₅₄O₆分子量:570.8作用靶点:NF-κB作用通路:NF-κB储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性HericenoneC是一种来源于猴头菌(Hericiumerinaceus)的代谢产物。HericenoneC能够抑制LPSLPS(HY-D1056)诱导的NRE::Luc荧光素酶活性，减少p65的磷酸化并抑制NF-κB信号传导。HericenoneC具有神经保护作用[1]。体外研究HericenoneC(2.5-20μM,1h)inhibitsluciferaseactivityandreducesp-P65levelsinLPS(HY-D1056)-inducedNIH3T3cellsexpressingNRE::Luc[1].HericenoneC(40μM,1h)inhibitstheFormalin-inducedincreaseinIL-6mRNAexpressionandreducesthepercentageofCD11c-positivecellsinRAW264.7cells[1].体内研究HericenoneC(2.5-10mg/kg,i.p.,45minsbeforeformalin)inhibitsthelicking/bitingtimeofthesecondphase(10-45min)inFormalin-inducednociceptivemodelofmaleICRmice[1].AnimalModel:Formalin-inducednociceptivemodelofmaleICRmice[1]Dosage:2.5,5and10mg/kgAdministration:Intraperitoneallyinjection,45minsbeforeformalinResult:Reducedlicking/bitingtimeofthesecondphase(10-45min).Showednosignificanteffectonthefirstphase(0-10min).ReducedtheaccumulationofCD11c-positivecellsinthepawepidermisandinhibitedtheactivationofp-P65inCD11c-positivecells.REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemELiJ,etal.HericenoneCattenuatesthesecondphaseofformalin-inducednociceptivebehaviorbysuppressingtheaccumulationofCD11c-positivecellsinthepawepidermisviaphosphorylatedP65.BiochemBiophysResCommun.2024Aug6;720:150077.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021