1-1-Naphthyl-piperazine-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE1-(1-Naphthyl)piperazineCat.No.:HY-W130288CASNo.:57536-86-4分子式:C₁₄H₁₆N₂分子量:212.29作用靶点:5-HTReceptor;AdenylateCyclase;Apoptosis;ReactiveOxygenSpecies(ROS)作用通路:GPCR/GProtein;NeuronalSignaling;Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性1-(1-Naphthyl)piperazine是一种5-HT受体调节剂，既可作为5-HT2A受体拮抗剂，又可作为5-HT1A受体激动剂，并且与人5-HT6受体的结合常数Ki为120nM。1-(1-Naphthyl)piperazine部分抑制小牛黑质中福斯克林刺激的腺苷酸环化酶(adenylatecyclase)活性。1-(1-Naphthyl)piperazine可抑制紫外线辐射诱导的免疫抑制。1-(1-Naphthyl)piperazine可诱导S期细胞周期延迟、细胞凋亡(apoptosis)并增加活性氧(ROS)水平，最终抑制MNT-1细胞增殖。1-(1-Naphthyl)piperazine可用于黑色素瘤研究[1][2][3][4]。IC50&TargetHuman5-HT6Receptor120nM(Ki)REFERENCESLeeM,etal.1-(1-Naphthyl)piperazineasanoveltemplatefor5-HT6serotoninreceptorligands.BioorgMedChemLett.2005Mar15;15(6):1707-11.SchoeffterP,etal.Interactionofarylpiperazineswith5-HT1A,5-HT1B,5-HT1Cand5-HT1Dreceptors:dodiscriminatory5-HT1Breceptorligandsexist?NaunynSchmiedebergsArchPharmacol.1989Jun;339(6):675-83.MenezesAC,etal.Developmentandcharacterizationofnovel1-(1-Naphthyl)piperazine-loadedlipidvesiclesforpreventionofUV-inducedskininflammation.EurJPharmBiopharm.2016Jul;104:101-9.MenezesAC,etal.Cytotoxiceffectoftheserotonergicdrug1-(1-Naphthyl)piperazineagainstmelanomacells.ToxicolInVitro.2018Mar;47:72-78.McePdfHeight1/1 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5