2DG-ODDA-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2DG-ODDACat.No.:HY-179631分⼦式:C₂₈H₅₁NO₁₀分⼦量:561.71作⽤靶点:Apoptosis作⽤通路:Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性2DG-ODDA⼀种具有强效抗肿瘤活性的2-脱氧葡萄糖(2-DG)(HY-13966)衍⽣物。2DG-ODDA可诱导细胞凋亡(apoptosis)并降低ATP⽣成。2DG-ODDA可通过脂酸和葡萄糖转运蛋⽩摄取，并被α-Mannosidase(HY-P2950)裂解，释放出2DG，从⽽抑制N-糖化并⼲扰细胞代谢。2DG-ODDA可抑制4T1⼩⿏模型中的肿瘤⽣长。2DG-ODDA可⽤于三性乳腺癌(TNBC)的研究[1]。体外研究2DG-ODDA(80μM;24h)demonstratessignificantreductioninglycolysis-based,mithochondrialandtotalATPproductionin4T1TNBCcells,indicatingthatitdisruptsmitochondrialmetabolisminadditiontoglycolysis.[1].2DG-ODDA(400μM;24h)inducesapoptosisin4T1TNBCcells[1].2DG-ODDA(24h)showscytotoxicityin4T1TNBCcellswithanIC50of~85μM,whichisa16-foldimprovementover2DG(IC50=~1.34mM)[1].2DG-ODDA(85μM;24h)istakenupthroughbothCD36(fattyacidtransporter)andglucosetransportersandiscleavedbyα-Mannosidase,releasing2DGtoinhibitN-glycosylationanddisruptcellularmetabolism[1].ApoptosisAnalysis[1]CellLine:4T1TNBCcellsConcentration:400μMIncubationTime:24hResult:Inducedamarkedincreaseinlate-apoptoticpopulations.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体内研究2DG-ODDA(7.5mg/kg;s.c.;threetimesweeklyfor2weeks)suppressestumorgrowthina4T1TNBCmousemodel[1].AnimalModel:BALB/cmicesubcutaneouslyinoculatedwith4T1cells[1]Dosage:7.5mg/kgAdministration:s.c.;threetimesweeklyfor2weeksResult:Significantlyattenuatedtumorprogression,withfinalmeantumorvolumes~40%lowerthanbothcontrolgroups.Showednotreatment-relatedweightlossorclinicalsignsofadverseevents.REFERENCES[1].JeonS,etal.ExploitingMetabolicVulnerabilitiesinCancerwithaDual-Transporter-Targeted2-DeoxyglucoseAnalogueforLow-Dose,PotentAntitumorActivity.JAmChemSoc.2025;147(47):43267-43272.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: