8-Bromo-cGMP-sodium-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE8-Bromo-cGMPsodium(Standard)Cat.No.:HY-101379ARCASNo.:51116-01-9分⼦式:C₁₀H₁₀BrN₅NaO₇P分⼦量:446.08作⽤靶点:CalciumChannel;ReferenceStandards作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling;Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性8-Bromo-cGMP(sodium)(Standard)8-Bromo-cGMP(sodium)(HY-101379A)的分析标准品。本产品⽤于研究及分析应⽤。8-Bromo-cGMPsodiumcGMP的膜渗透性类似物，⼀种PKG激活剂。8-Bromo-cGMPsodium可显抑制Ca2+宏观电流并损害⾼K+刺激的胰岛素释放。8-Bromo-cGMPsodium具有缓解疼痛和⾎管REFERENCES[1].SarkarO,etal.NitricoxideattenuatesoverexpressionofGiαproteinsinvascularsmoothmusclecellsfromSHR:RoleofROSandROS-mediatedsignaling.PLoSOne.2017Jul10;12(7):e0179301.[2].TegederI,etal.Dualeffectsofspinallydelivered8-bromo-cyclicguanosinemono-phosphate(8-bromo-cGMP)informalin-inducednociceptioninrats.NeurosciLett.2002Oct31;332(2):146-50.[3].TobiasPolte,etal.Atrialnatriureticpeptidereducescyclosporintoxicityinrenalcells:roleofcGMPandhemeoxygenase-1.FreeRadicBiolMed.2002Jan1;32(1):56-63.[4].JunzoKamei,etal.Possibleinvolvementofthespinalnitricoxide/cGMPpathwayinvincristine-inducedpainfulneuropathyinmice.Pain.2005Sep;117(1-2):112-20.[5].ElzaDvanDeel,etal.Vasomotorcontrolinmiceoverexpressinghumanendothelialnitricoxidesynthase.AmJPhysiolHeartCircPhysiol.2007Aug;293(2):H1144-53.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559