Anticancer-agent-285-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAnticanceragent285Cat.No.:HY-179486CASNo.:2878446-03-6分⼦式:C₁₂H₁₄N₆O₂S分⼦量:306.34作⽤靶点:HaspinKinase作⽤通路:CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Anticanceragent285⼀种⼝服有效的抗癌药物，具有⾼效且选择性的haspin抑制活性(IC50=18nM)。Anticanceragent285可⽤于结直肠癌的研究[1]。IC50&Targethaspin18nM(IC50)体外研究Anticanceragent285(Compound1d)(72h)exhibitsIC50valuesof3.31μMinSK-Hep-1cells,3.91μMinMDA-MB-231cells,4.82μMinHCT116cells,19.7μMinA549cells,and3.58μMinSNU-638cells[1].体内研究Anticanceragent285(Compound1d)(10mg/kg,p.o./i.p.,threetimesperweekfor23days)significantlyinhibitstumorgrowthinahumancolorectalcancercellline(HCT116cells)xenograftmousemodelwithoutshowingsignificanttoxicity[1].AnimalModel:HCT116cells(7×106cellspermouse)wereinjectedsubcutaneouslyintotheflanksoftheMaleBalb/c-numice(male,aged4weeks)[1].Dosage:10mg/kgAdministration:P.o.,i.p.,threetimesperweekfor23daysResult:Theoraladministrationresultedinatumorinhibitionrateof51.7%.Theintraperitonealinjectionresultedinatumorinhibitionrateof46.2%.Nosignificantweightlossorobvioustoxicitysymptomswereobservedinanyofthe1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEmice.REFERENCES[1].YumYA,etal.Designanddevelopmentof5'-modified7-substituted4'-thionucleosidesaspotentHaspininhibitors:Synthesisandbiologicalevaluation.BioorgChem.2025Nov;166:109146.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-