Apoptosis-inducer-53-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEApoptosisinducer53Cat.No.:HY-179451分⼦式:C₂₆H₃₉F₂NO₆S分⼦量:531.65作⽤靶点:Apoptosis;p38MAPK;Parasite作⽤通路:Apoptosis;MAPK/ERKPathway;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Apoptosisinducer53⼀种凋亡(apoptosis)诱导剂。Apoptosisinducer53能够抑制⼈类肿瘤细胞系(A549、HeLa、SW1573、T-47D、WiDr)的增殖，其GI50值为2.5-9.1μM。Apoptosisinducer53可以诱导癌细胞凋亡并减少集落形成。Apoptosisinducer53能够激活p38αMAPK信号通路，并发挥抗炎作⽤。Apoptosisinducer53还具有抗杜⽒利什曼原⾍(Leishmaniadonovani)活性。Apoptosisinducer53可⽤于癌症、感染和炎症的研究。体外研究Apoptosisinducer53(Compound24)(2.5-9.1μM)inhibitsproliferationofhumantumorcelllines(A549,HeLa,SW1573,T-47D,WiDr)withGI50valuesof3.7μM,2.5μM,3.7μM,9.1μMand4.9μMrespectively[1].Apoptosisinducer53(25μM,20h)inducestypicalapoptoticphenotypesinHeLacells[1].Apoptosisinducer53(7.5-12.5μM,24hor0.83-2.5μM,7days)dose-dependentlyreducescolonyformationinHeLacells[1].Apoptosisinducer53inhibitsthegrowthofLeishmaniadonovaniamastigotesinTHP-1-differentiatedmacrophageswithanIC50of2.59μM[1].Apoptosisinducer53(10μM,24h)inhibitsNLRP3,Caspase-1andIL-1βproductionbyactivatingp38αMAPKinLPS(HY-D1056)-stimulatedBV.2microglialcells[1].ApoptosisAnalysis[1]CellLine:HeLacellsConcentration:25μMIncubationTime:20h1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Showedcellshrinkageandcontentfragmentation.CausednuclearcondensationandfragmentationandshowedpositiveAnnexinVstaining.DidnotinduceROSproduction,disruptmitochondrialmembranepotential,oraffectcellmicrotubulestructure.REFERENCES[1].Padilla-PérezMC,etal.Exploringtheinfluenceoftheglyconespaceonthetherapeuticpotentialofsp-iminoglycolipids.EurJMedChem.2026;302(Pt2):118337.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400