Auristatin-E-d8-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAuristatinE-d8Cat.No.:HY-15582S分⼦式:C₄₀H₆₁D₈N₅O₇分⼦量:740.05作⽤靶点:Isotope-LabeledCompounds;Microtubule/Tubulin;ADCPayload作⽤通路:Others;CellCycle/DNADamage;Cytoskeleton;Antibody-drugConjugate/ADCRelated储存⽅式:-20°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)BIOLOGICALACTIVITY⽣物活性AuristatinE-d8AuristatinE(HY-15582)的氘代物。AuristatinE⼀种细胞毒性微管蛋⽩聚合抑制剂，具有选择性抗肿瘤活性。AuristatinE抗体-药物偶联药物(ADC)中的细胞毒素。AuristatinE通过阻断微管蛋⽩的聚合抑制细胞分裂，有望⽤于B细胞恶性肿瘤的研究。AuristatinEDolastatin10(HY-15580)的合成类似物，由四个氨酸组成的线性肽。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].MADDONPaulJ,etal.PSMAANTIBODIESANDPROTEINMULTIMER.2002October23.WO03/034903A2[2].PeterD.Senter,etal.PENTAPEPTIDECOMPOUNDSANDUSESRELATEDTHERETO.2005Jan.13.US2005/0009751Al.[3].LAW,Che-Leung,etal.TREATMENTOFIMMUNOLOGICALDISORDERS5USINGANTI-CD30ANTIBODIES.2002November20.WO03/043583A2.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02