Calcimycin-hemicalcium-hemimagnesium-A-23187-hemicalcium-hemimagnesium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECalcimycinhemicalciumhemimagnesiumCat.No.:HY-N6687CSynonyms:A-23187hemicalciumhemimagnesium;AntibioticA-23187hemicalciumhemimagnesium分⼦式:C₂₉H₃₇N₃O₆.₁/₄Ca.₁/₄Me分⼦量:555.59作⽤靶点:OxidativePhosphorylation;Bacterial;Fungal;Apoptosis;Autophagy;Antibiotic作⽤通路:MetabolicEnzyme/Protease;Anti-infection;Apoptosis;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Calcimycin(A-23187)hemicalciumhemimagnesium⼀种抗⽣素和独特的⼆价阳离⼦离⼦载体，如钙离⼦和镁离⼦。Calcimycinhemicalciumhemimagnesium通过增加细胞内钙浓度诱导Ca2+依赖性细胞死亡。Calcimycinhemicalciumhemimagnesium抑制⾰兰⽒阳性细和⼀些真的⽣长，还抑制ATP酶的活性并解耦哺乳动物细胞的氧化磷酸化(OXPHOS)，诱导细胞凋亡(apoptosis)和⾃噬(autophagy)。户使⽤本产品发表的科研⽂献•CancerCommun(Lond).2023Jan;43(1):123-149.•AdvSci(Weinh).2025Aug20:e11873.•MolTher.2022Dec7;30(12):3694-3713.•Brain.2024Nov4;147(11):3764-3779.•ProcNatlAcadSciUSA.2025Sep2;122(35):e2513155122.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].WuQ,etal.Characterizationofthebiosynthesisgeneclusterforthepyrrolepolyetherantibioticcalcimycin(A23187)inStreptomyceschartreusisNRRL3882.AntimicrobAgentsChemother.2011Mar;55(3):974-82.[2].ElliottJI,etal.IKCa1activityisrequiredforcellshrinkage,phosphatidylserinetranslocationanddeathinTlymphocyteapoptosis.EMBO1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemERep.2003Feb;4(2):189-94.[3].EngedalN,etal.Modulationofintracellularcalciumhomeostasisblocksautophagosomeformation.Autophagy.2013Oct;9(10):1475-90.[4].MawatwalS,etal.Calcimycinmediatesmycobacterialkillingbyinducingintracellularcalcium-regulatedautophagyinaP2RX7dependentmanner.BiochimBiophysActaGenSubj.2017Dec;1861(12):3190-3200.[5].WangJP,etal.Effectofnorathyriol,isolatedfromTripterospermumlanceolatum,onA23187-inducedpleurisyandanalgesiainmice.NaunynSchmiedebergsArchPharmacol.1994Jul;350(1):90-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te