Calciseptine-TFA-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECalciseptineTFACat.No.:HY-P3269A分⼦式:C₂₉₉H₄₆₈N₉₀O₈₇S₁₀.xC₂HF₃O₂Sequence:Arg-Ile-Cys-Tyr-Ile-His-Lys-Ala-Ser-Leu-Pro-Arg-Ala-Thr-Lys-Thr-Cys-Val-Glu-Asn-Thr-Cys-Tyr-Lys-Met-Phe-Ile-Arg-Thr-Gln-Arg-Glu-Tyr-Ile-Ser-Glu-Arg-Gly-Cys-Gly-Cys-Pro-Thr-

Ala-Met-Trp-Pro-Tyr-Gln-Thr-Glu-Cys-Cys-Lys-Gly-Asp-Arg-Cys-Asn-Lys(Disulfidebridge

:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52;Cys53-Cys58)SequenceRICYIHKASLPRATKTCVENTCYKMFIRTQREYISERGCGCPTAMWPYQTECCKGDRCNKShortening:(Disulfidebridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52;Cys53-Cys58)作⽤靶点:CalciumChannel作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性CalciseptineTFA，⼀种可从⿊曼巴蛇(Dendroaspisp.polylepis)毒液中发现的天然多肽毒素。CalciseptineTFACav1.2亚型的L型通道的⾼效、选择性阻断剂，其IC50值为92nM。CalciseptineTFA对Cav3.1、Cav2.2、Cav2.1、Cav1.1、电压敏感性钠通道和钾通道⽆响。CalciseptineTFA对⼩⿏具有负性肌⼒和负性松弛效应，且不响⼼率、对窦房结起搏细胞动作电位⽆响。CalciseptineTFA可⽤于研究⼼⾎管疾病。IC50&TargetCav1.292nM(IC50)REFERENCES[1].MesircaP,etal.SelectiveblockadeofCav1.2(α1C)versusCav1.3(α1D)L-typecalciumchannelsbytheblackmambatoxincalciseptine.NatCommun.2024Jan2;15(1):54.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-