补阳还五汤加味治疗特发性膜性肾病的临床疗效观察

补阳还五汤加味治疗特发性膜性肾病的临床疗效观察【摘要】目的：探讨补阳还五汤加味在治疗特发性膜性肾病（IMN）中的临床疗效。方法：选取2018年1月至2020年1月期间，在我院接受治疗的IMN患者60例，随机分为两组，对照组30例采用常规西医治疗方法，观察组30例在对照组的基础上加用补阳还五汤加味治疗。比较两组患者的临床疗效、肾功能指标、血清免疫学指标以及生活质量的变化情况。结果：经过为期8周的治疗，观察组和对照组的总有效率分别为93.33%和76.67%，差异具有统计学意义(P<0.05)。治疗后，两组患者的血肌酐、尿素氮、尿蛋白定量等肾功能指标均较治疗前明显改善，且观察组的改善程度优于对照组(P<0.05)。此外，观察组的血清免疫学指标如C3、C4、IgG、IgM等也较治疗前有所改善，且与对照组相比差异显著(P<0.05)。最后，通过问卷调查发现，观察组患者的生活质量评分明显高于对照组(P<0.05)。结论：补阳还五汤加味在治疗IMN中具有良好的临床疗效，能够有效改善患者的肾功能指标、血清免疫学指标，并提高患者的生活质量。因此，建议将补阳还五汤加味作为IMN治疗的辅助手段，以期达到更好的治疗效果。【关键词】补阳还五汤；特发性膜性肾病；临床疗效；肾功能；血清免疫学指标；生活质量【Abstract】Objective:ToinvestigatetheclinicalefficacyofBuYangHuanWuTangplusmodifiedtreatmentintreatingidiopathicmembranousnephropathy(IMN).Methods:FromJanuary2018toJanuary2020,atotalof60patientswithIMNwereselectedandrandomlydividedintotwogroups,including30casesinthecontrolgrouptreatedwithconventionalWesternmedicineand30casesintheobservationgrouptreatedwithBuYangHuanWuTangplusmodifiedtreatment.Theclinicalefficacy,renalfunctionindicators,serumimmunologicalindicators,andqualityoflifechangeswerecomparedbetweenthetwogroups.Results:After8weeksoftreatment,thetotaleffectiverateoftheobservationgroupandthecontrolgroupwas93.33%and76.67%,respectively,whichhadstatisticalsignificance(P<0.05).Aftertreatment,therenalfunctionindicatorssuchasbloodcreatinine,ureanitrogen,andurinaryproteinquantitativelyinbothgroupsweresignificantlyimproved,andtheimprovementintheobservationgroupwasbetterthanthatinthecontrolgroup(P<0.05).Inaddition,theserumimmunologicalindicatorssuchasC3,C4,IgG,IgMintheobservationgroupwerealsoimprovedaftertreatment,andthedifferencewassignificantcomparedwiththecontrolgroup(P<0.05).Finally,throughquestionnairesurvey,itwasfoundthatthequalityoflifescoreintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.05).Conclusion:BuYangHuanWuTangplusmodifiedtreatmenthasgoodclinicalefficacyintreatingIMN,caneffectivelyimprovetherenalfunctionindicators,serumimmunologicalindicators,andimprovethequalityoflife.Therefore,itissuggestedthatBuYangHuanWuTangplusmodifiedtreatmentshouldbeusedasanauxiliarymeansinthetreatmentofIMNtoachievebettertreatmenteffects.【Keywords】BuYangHuanWuTang;Idiopathicmembranousnephropathy;Clinicalefficacy;Renalfunction;Serumimmunologicalindicators;Qualityoflife銆怉bstract銆慭nObjective:ToinvestigatetheclinicalefficacyofBuYangHuanWuTangplusmodifiedtreatmentintreatingidiopathicmembranousnephropathy(IMN).Methods:FromJanuary2018toJanuary2020,atotalof60patientswithIMNwereselectedandrandomlydividedintotwogroups,including30casesinthecontrolgrouptreatedwithconventionalWesternmedicineand30casesintheobservationgrouptreatedwithBuYangHuanWuTangplusmodifiedtreatment.Theclinicalefficacy,renalfunctionindicators,serumimmunologicalindicators,andqualityoflifechangeswerecomparedbetweenthetwogroups.Results:After8weeksoftreatment,thetotaleffectiverateoftheobservationgroupandthecontrolgroupwas93.33%and76.67%,respectively,whichhadstatisticalsignificance(P<0.05).Aftertreatment,therenalfunctionindicatorssuchasbloodcreatinine,ureanitrogen,andurinaryproteinquantitativelyinbothgroupsweresignificantlyimproved,andtheimprovementintheobservationgroupwasbetterthanthatinthecontrolgroup(P<0.05).Inaddition,theserumimmunologicalindicatorssuchasC3,C4,IgG,IgMintheobservationgroupwerealsoimprovedaftertreatment,andthedifferencewassignificantcomparedwiththecontrolgroup(P<0.05).Finally,throughquestionnairesurvey,itwasfoundthatthequalityoflifescoreintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.05).Conclusion:BuYangHuanWuTangplusmodifiedtreatmenthasgoodclinicalefficacyintreatingIMN,caneffectivelyimprovetherenalfunctionindicators,serumimmunologicalindicators,andimprovethequalityoflife.Therefore,itissuggestedthatBuYangHuanWuTangplusmodifiedtreatmentshouldbeusedasan