BV02-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBV02(Standard)Cat.No.:HY-101985RCASNo.:292870-53-2分⼦式:C₂₀H₁₅N₃O₅分⼦量:377.36作⽤靶点:ReferenceStandards;Bacterial;PARP;Caspase;Apoptosis;Autophagy;Akt作⽤通路:Others;Anti-infection;CellCycle/DNADamage;Epigenetics;Apoptosis;Autophagy;PI3K/Akt/mTOR储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性BV02(Standard)BV02(HY-101985)的分析标准品。本产品⽤于研究及分析应⽤。BV02⼀个14-3-3抑制剂和抗剂。BV02可增强PARP和caspase-3的裂解。BV02可诱导细胞凋亡(Apoptosis)、⾃噬(Apoptosis)，并增强Akt的激活。BV02具有抗B.melitensis感染和促癫痫作⽤。BV02还可⽤于结肠炎研REFERENCES[1].ManciniM,etal.Anewnonpeptidicinhibitorof14-3-3inducesapoptoticcelldeathinchronicmyeloidleukemiasensitiveorresistanttoimatinib.JPharmacolExpTher.2011Mar;336(3):596-604.[2].Fernández-OrthJ,etal.14-3-3ProteinsregulateK2P5.1surfaceexpressiononTlymphocytes.Traffic.2017Jan;18(1):29-43.[3].KimHJ,etal.SubcellularlocalizationofFOXO3aasapotentialbiomarkerofresponsetocombinedtreatmentwithinhibitorsofPI3KandautophagyinPIK3CA-mutantcancercells.Oncotarget.2017Jan24;8(4):6608-6622.[4].Gómez-SuárezM,etal.14-3-3ProteinsregulateAktThr308phosphorylationinintestinalepithelialcells.CellDeathDiffer.2016Jun;23(6):1060-72.[5].WenY,etal.HAP1interactswith14-3-3toregulateepilepticseizureviaGABAAR-mediatedinhibitorysynaptictransmissioninpentylenetetrazoleratmodel.NeurosciRes.2022Sep;182:7-14.[6].JoshiK,etal.Brucellatargetsthehostubiquitin-specificprotease,Usp8,throughtheeffectorprotein,TcpB,forfacilitatinginfectionofmacrophages.InfectImmun.2024Feb13;92(2):e0028923.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792