Daporinad-hydrochloride-FK866-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDaporinadhydrochlorideCat.No.:HY-50876ACASNo.:2727965-45-7Synonyms:FK866hydrochloride;APO866hydrochloride分⼦式:C₂₄H₃₀ClN₃O₂分⼦量:427.97作⽤靶点:NAMPT;Autophagy;Apoptosis;mTOR;p38MAPK;ERK作⽤通路:MetabolicEnzyme/Protease;Autophagy;Apoptosis;PI3K/Akt/mTOR;MAPK/ERKPathway;StemCell/Wnt储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Daporinad(FK866)hydrochloride⼀种⾮竞争性的烟酰胺磷酸核糖转移酶(Nampt)的抑制剂，其Ki为0.3nM。Daporinadhydrochloride耗竭NAD+和ATP⽔平，抑制mTORC1和MAPK/ERK通路并激活TFEB诱导细胞⾃噬(autophagy)。Daporinadhydrochloride引起内质⽹Ca²库排空，最终削弱了丝裂原诱导的Ca²信号和T细胞的激活与功能。Daporinadhydrochloride诱导细胞周期阻滞和凋亡(apoptosis)，抑制细胞增殖。Daporinadhydrochloride可⽤于研究⾻髓瘤、肝癌和免疫抑制。户使⽤本产品发表的科研⽂献•CellMetab.2024Jun18:S1550-4131(24)00189-X.•Hepatology.2023Aug1;78(2):468-485.•NatCommun.2024Nov12;15(1):9515.•CellDeathDiffer.2024Feb;31(2):239-253.•AdvSci(Weinh).2025Jan31:e2412282.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CeaM,etal.TargetingNAD+salvagepathwayinducesautophagyinmultiplemyelomacellsviamTORC1andextracellularsignal-regulatedkinase(ERK1/2)inhibition.Blood.2012Oct25;120(17):3519-29.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[2].MagnoneM,etal.NAD+levelscontrolCa2+storereplenishmentandmitogen-inducedincreaseofcytosolicCa2+byCyclicADP-ribose-dependentTRPM2channelgatinginhumanTlymphocytes.JBiolChem.2012Jun15;287(25):21067-81.[3].ThakurBK,etal.InhibitionofNAMPTpathwaybyFK866activatesthefunctionofp53inHEK293Tcells.BiochemBiophysResCommun.2012Aug3;424(3):371-7.[4].HasmannM,SchemaindaI.FK866,ahighlyspecificnoncompetitiveinhibitorofnicotinamidephosphoribosyltransferase,representsanovelmechanismforinductionoftumorcellapoptosis.CancerRes.2003Nov1;63(21):7436-42.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4