Diquat-d12-dibromide-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDiquat-d12dibromide1Cat.No.:HY-122984S1分⼦式:C₁₂D₁₂Br₂N₂分⼦量:356.12作⽤靶点:Isotope-LabeledCompounds;Autophagy;MitochondrialMetabolism;ReactiveOxygenSpecies(ROS);Herbicide作⽤通路:Others;Autophagy;MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Diquat-d12dibromide1氘代标记的Diquatdibromide(HY-122984)。Diquatdibromide⼀种综合性除草剂(herbicide)。Diquatdibromide增加ROS的产⽣、触发线粒体⾃噬(mitochondrialAutophagy)。Diquatdibromide通过氧化还原循环产⽣超氧离⼦等⾃由，引发氧化应激反应。Diquatdibromide具有细胞、⽣殖和神经毒性。Diquatdibromide⽤于棉花、⼤⾖和其他作物的种植，以对抗有害杂草[1][2][3][4][5][6][7][8]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].MorelandDE.Mechanismsofactionofherbicides.1980.[2].CaoS,etal.Diquat-inducedoxidativestressincreasesintestinalpermeability,impairsmitochondrialfunction,andtriggersmitophagyinpiglets.JAnimSci.2018May4;96(5):1795-1805.[3].SinghP,etal.Sirtuin-2ProtectsNeuralCellsfromOxidativeStressandIsElevatedinNeurodegeneration.ParkinsonsDis.2017;2017:2643587.[4].TomášekO,etal.Opposingeffectsofoxidativechallengeandcarotenoidsonantioxidantstatusandcondition-dependentsexualsignalling.SciRep.2016Mar22;6:23546.[5].NisarR,etal.Diquatcausescaspase-independentcelldeathinSH-SY5YcellsbyproductionofROSindependentlyofmitochondria.ArchToxicol.2015Oct;89(10):1811-25.[6].ZhangJQ,etal.ChronicExposuretoDiquatCausesReproductiveToxicityinFemaleMice.PLoSOne.2016Jan19;11(1):e0147075.[7].KaruppagounderSS,etal.Investigatethechronicneurotoxiceffectsofdiquat.NeurochemRes.2012May;37(5):1102-11.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[8].AcarA.Invivotoxicologicalassessmentofdiquatdibromide:cytotoxic,genotoxic,andbiochemicalapproach.EnvironSciPollutResInt.2021;28(34):47550-47561.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch