DL-Mevalonolactone-d4-racemic-Mevalonolactone-d-sub-4-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDL-Mevalonolactone-d4Cat.No.:HY-W752587CASNo.:349553-98-6Synonyms:(±)-Mevalonolactone-d4;Mevalolactone-d4分⼦式:C₆H₆D₄O₃分⼦量:134.17作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性DL-Mevalonolactone-d4((±)-Mevalonolactone-d4)氘代标记的DL-Mevalonolactone(HY-107855)。DL-Mevalonolactone((±)-Mevalonolactone;Mevalolactone)甲羟戊酸的δ-lactone形式，甲羟戊酸途径的⼀个前体。DL-Mevalonolactone对HMGCR突变和statin导致的肌病具有⼝服活性[3]。DL-Mevalonolactone诱导炎症和氧化应激反应，降低线粒体膜电位，形成线粒体肿胀[2][4]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].DomingosSR,etal.Onthestructuralintricaciesofametabolicprecursor:Directspectroscopicdetectionofwater-inducedconformationalreshapingofmevalonolactone.JChemPhys.2017Sep28;147(12):124310.[2].CecattoC,etal.Mevalonolactonedisruptsmitochondrialfunctionsandinducespermeabilitytransitionporeopeninginratbrainmitochondria:Implicationsforthepathogenesisofmevalonicaciduria.NeurochemInt.2017Sep;108:133-145.[3].YogevY,etal.,LimbgirdlemusculardiseasecausedbyHMGCRmutationandstatinmyopathytreatablewithmevalonolactone.ProcNatlAcadSciUSA.2023Feb14;120(7):e2217831120.[4].GrattonR,etal.,Prolongedtreatmentwithmevalonolactoneinducesoxidativestressresponsewithreactiveoxygenspeciesproduction,mitochondrialdepolarizationandinflammationinhumanglioblastomaU-87MGcells.NeurochemInt.2018Nov;120:233-237.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:40