FSC-PEG4-αvβ6-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFSC(PEG4-αvβ6)₃Cat.No.:HY-179583分⼦式:C₂₃₇H₃₅₄N₅₄O₆₉分⼦量:5063.67作⽤靶点:Integrin作⽤通路:Cytoskeleton储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性FSC(PEG4-avb6)3⼀种靶向αvβ6整合素三聚体的⽰踪剂(IC50=0.69nM)。FSC(PEG4-avb6)3可⽤于研究头颈癌、肺癌、乳腺癌和胰腺癌[1]。IC50&Targetαvβ60.69nM(IC50)体外研究[68Ga]Ga-FSC(PEG4-avb6)3exhibitsaLogD(pH7.4)valueof-1.4,whereas[89Zr]Zr-FSC(PEG4-avb6)3showsaLogD(pH7.4)of-0.9[1].[68Ga]Ga-FSC(PEG4-avb6)3showsspecificuptakeof3.9%inH2009cells,whileuptakewasnegligibleinMDA-MB-231cells[1].体内研究Ga-FSC(PEG4-avb6)3(120-400pmol,i.v.,once)caneffectivelytargetH2009humanlungadenocarcinomacells(αvβ6positive)tumorsinxenograftmice[1].AnimalModel:Xenografttumor-bearingmodelswereestablishedbysubcutaneoustransplantationof5×106H2009humanlungadenocarcinomacells(αvβ6positive)intoCB17SCIDmice(female,6-10weeksold)[1].Dosage:[68Ga]Ga-FSC(PEG4-avb6)3:120-140pmol[89Zr]Zr-FSC(PEG4-avb6)3:200-400pmolAdministration:I.v.,onceResult:[68Ga]Ga-FSC(PEG4-avb6)3showedtumoruptakeof1.4%ID/g.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[89Zr]Zr-FSC(PEG4-avb6)3wassuitableforextendingtheimagingwindowandshowedgoodtumorpreservation,butitsstabilitywaslimited.REFERENCES[1].GariglioG,etal.SynthesisandPreclinicalDevelopmentofaNovel68Ga/89Zr-Labelledανβ6-IntegrinTargetingTrimer.bioRxiv[Preprint].2025Nov06:2025.11.05.686720.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589