Guanine-d5-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGuanine-d5Cat.No.:HY-Y1055S6分⼦式:C₅D₅N₅O分⼦量:156.16作⽤靶点:Isotope-LabeledCompounds;DNA/RNASynthesis;EndogenousMetabolite作⽤通路:Others;CellCycle/DNADamage;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Guanine-d5氘代标记的Guanine(HY-Y1055)。Guanine核酸(DNA和RNA)的本组分之⼀。Guanine⼀种嘌呤衍⽣物，由具有共轭双键的稠合嘧啶-咪唑环系统组成。Guanine具有作为⼤容量氮库的潜⼒。Guanine具有细胞毒性、抗痛和神经保护作⽤[1][2][3][4]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].ChauhanV,etal.InSilicoDiscoveryandValidationofAmideBasedSmallMoleculeTargetingtheEnzymaticSiteofShigaToxin.JMedChem.2016Dec8;59(23):10763-10773.[2].MessinaE,etal.Guaninenucleotidedepletiontriggerscellcyclearrestandapoptosisinhumanneuroblastomacelllines.IntJCancer.2004Mar1;108(6):812-7.[3].deOliveiraED,etal.Mechanismsinvolvedintheantinociceptioninducedbyspinaladministrationofinosineorguanineinmice.EurJPharmacol.2016Feb5;772:71-82.[4].MojzešP,etal.Guanine,ahigh-capacityandrapid-turnovernitrogenreserveinmicroalgalcells.ProcNatlAcadSciUSA.2020Dec22;117(51):32722-32730.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559