IPS-05002-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIPS-05002Cat.No.:HY-118273CASNo.:1185036-77-4分⼦式:C₂₂H₁₉FN₄O₂S分⼦量:422.48作⽤靶点:Integrin作⽤通路:Cytoskeleton储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性IPS-05002⼀种α5β1受体拮抗剂。IPS-05002可抑制VEGF刺激的⼈脐静脉内⽪细胞(HUVEC)的增殖、黏附和迁移，并抑制管状⽹络的形成。IPS-05002可上调VEGF诱导的HUVEC中IKB-β和XRCC4的表达，并下调Cdc6的表达。IPS-05002可⽤于肿瘤⾎管⽣成的研究[1]。IC50&Targetα5β1体外研究IPS-05002(0.78-200μM,1h)inhibitsthebindingofintegrinα5β1tofibronectininadose-dependentmanner[1].IPS-05002(72h)markedlysuppressestheproliferationandadhesionofHUVEC(IC50=20.5μM)[1].IPS-05002(6.25-1700μM,0-24h)significantlyperturbsVEGF-inducedHUVECmigrationinadoseandtime-dependentfashion(IC50=15.52μM)[1].IPS-05002(3-50μM,90min)dose-dependentlyinhibitstheadhesionofHUVECstoMatrigel[1].IPS-05002(24h)upregulatesVEGF-inducedIκB-βandXRCC4inHUVECsanddownregulatesCdc6proteinexpression[1].CellMigrationAssay[1]CellLine:humanumbilicalveinendothelialcell(HUVEC)Concentration:6.25μM,12.5μM,25μM,50μM,100μM,106.25μM,212.5μM,425μM,850μM,1700μMIncubationTime:0h,12h,24h1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:SignificantlyperturbedVEGF-inducedHUVECmigrationcomparedwithGRGDSP-treatedcontrolgroupinadoseandtime-dependentfashion.REFERENCES[1].Kim,etal.Anti-angiogenicmechanismofIPS-05002,anovelantagonistagainstintegrina5β1,determinedbyProteoChip-basedantibodyarray.BioChipJournal,10(3),174–181.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-