Iptacopan-hydrochloride-hydrate-LNP023-hydrochloride-hydrate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIptacopanhydrochloridehydrateCat.No.:HY-200854CASNo.:2447007-60-3Synonyms:LNP023hydrochloridehydrate分⼦式:C₂₅H₃₃ClN₂O₅分⼦量:476.99作⽤靶点:ComplementSystem作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Iptacopan(LNP023)hydrochloridehydrate⼀种有效的，具有⼝服活性的⾼选择性的factorB抑制剂，IC50值为10nM，KD为7.9nM。Iptacopanhydrochloridehydrate通过在补体级联反应中发挥近端作⽤，防⽌PNH中红细胞的破坏(溶⾎)以及IgAN和C3G中肾细胞的损伤。Iptacopanhydrochloridehydrate可⽤于研究补体介导疾病，特别阵发性睡眠性⾎红蛋⽩尿症(PNH)、原发性免疫球蛋⽩A肾病(IgAN)和补体3肾⼩球病(C3G)。户使⽤本产品发表的科研⽂献•CellStemCell.2023Oct5;30(10):1315-1330.e10.•GutMicrobes.2025Dec;17(1):2484386.•ProcNatlAcadSciUSA.2025Jun3;122(22):e2424570122.•BiomedPharmacother.2022Sep:153:113433.•BloodAdv.2024Jun12:bloodadvances.2024012874.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].DimitriosCMastellos,etal.ExpandingComplementTherapeuticsfortheTreatmentofParoxysmalNocturnalHemoglobinuria.SeminHematol.2018Jul;55(3):167-175.[2].AnnaSchubart,etal.Small-moleculeFactorBInhibitorfortheTreatmentofComplement-MediatedDiseases.ProcNatlAcadSciUSA.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2019Apr16;116(16):7926-7931.[3].NelloMainolfi,etal.Discoveryof4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicAcid(LNP023),aFactorBInhibitorSpecificallyDesignedToBeApplicabletoTreatingaDiverseArrayofComplementMediatedDiseases.JMedChem.2020Jun11;63(11):5697-5722.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02