Levomepromazine-d6-hydrochloride-Methotrimeprazine-d-sub-6-sub-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELevomepromazine-d6hydrochlorideCat.No.:HY-166562SSynonyms:Methotrimeprazine-d6hydrochloride分⼦式:C₁₉H₁₉D₆ClN₂OS分⼦量:370.97作⽤靶点:Isotope-LabeledCompounds;DopamineReceptor;Calcium

Channel;5-HTReceptor;Autophagy;HistamineReceptor;

Enterovirus作⽤通路:Others;GPCR/GProtein;NeuronalSignaling;MembraneTransporter/IonChannel;Autophagy;Immunology/Inflammation;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Levomepromazine-d6hydrochloride(Methotrimeprazine-d6hydrochloride)氘代标记的Levomepromazinehydrochloride。Levomepromazine(Methotrimeprazine)hydrochloride具有⼝服活性的抗精神疾病的化合物和Ca2+释放诱导剂。Levomepromazinehydrochloride可抑制SERCA泵并诱导细胞质Ca2+⽔平增加。Levomepromazinehydrochloride对多种神经递质受体(neurotransmitterreceptors)具有拮抗作⽤，包括多巴胺能、胆碱能、⾎素和组胺受体。Levomepromazinehydrochloride能诱导适应性内质⽹应激和⾃噬(autophagy)。此外，Levomepromazinehydrochloride还具有抗病毒、抗炎、神经保护和镇痛、抗伤害的活性。Levomepromazinehydrochloride可⽤于精神疾病以及缓解恶⼼和呕吐的研究。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].PrajapatSK,etal.MethotrimeprazineisaneuroprotectiveantiviralinJEVinfectionviaadaptiveERstressandautophagy.EMBOMolMed.2024Jan;16(1):185-217.[2].PettsHV,etal.Interactionsofmorphineandmethotrimeprazineinmouseandmanwithrespecttoanalgesia,respirationandsedation.BrJAnaesth.1983May;55(5):437-41.[3].CoxL,etal.Levomepromazinefornauseaandvomitinginpalliativecare.CochraneDatabaseSystRev.2015Nov2;(11):CD009420.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[4].SivaramanP,etal.Levomepromazineforschizophrenia.CochraneDatabaseSystRev.2010Oct6;(10):CD007779.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: