Orazipone-OR-1384-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOraziponeCat.No.:HY-106981CASNo.:137109-78-5Synonyms:OR1384分⼦式:C₁₃H₁₄O₄S分⼦量:266.31作⽤靶点:NADPHOxidase;ReactiveOxygenSpecies(ROS);Apoptosis;NF-κB;NOSynthase;STAT作⽤通路:MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κB;Apoptosis;JAK/STATSignaling;StemCell/Wnt储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Orazipone(OR1384)⼀种具有强⼤抗炎特性的⼩分⼦免疫调节剂。Orazipone通过形成可逆的硫醇结合物，与细胞内信号蛋⽩和⾕胱⽢肽的硫醇团结合，发挥其免疫调节作⽤。Orazipone通过诱发凋亡(apoptosis)，具有强⼤的抗嗜酸性粒细胞活性。Orazipone可抑制炎症转录因⼦(NF-κB和STAT1)的激活，并降低因炎症刺激⽽诱导的iNOS表达和NO的⽣成。Orazipone抑制NADPH氧化酶活性，减少ROS产⽣。Orazipone在肠道辐射损伤中具有保护作⽤。IC50&TargetNF-κBSTAT1iNOSREFERENCES[1].SareilaO,etal.Oraziponeinhibitsactivationofinflammatorytranscriptionfactorsnuclearfactor-kappaBandsignaltransducerandactivatoroftranscription1anddecreasesinduciblenitric-oxidesynthaseexpressionandnitricoxideproductioninresponsetoinflammatorystimuli.JPharmacolExpTher.2008Feb;324(2):858-66.[2].BoermaM,etal.Orazipone,alocallyactingimmunomodulator,amelioratesintestinalradiationinjury:apreclinicalstudyinanovelratmodel.IntJRadiatOncolBiolPhys.2006Oct1;66(2):552-9.[3].KankaanrantaH,etal.Antieosinophilicactivityoforazipone.MolPharmacol.2006Jun;69(6):1861-70.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a