racemic-Clopidogrel-d4-racemic-Clopidogrelum-d-sup-4-sup-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(±)-Clopidogrel-d4Cat.No.:HY-15283AS1CASNo.:1219274-95-9Synonyms:(±)-Clopidogrelum-d4分⼦式:C₁₆H₁₂D₄ClNO₂S分⼦量:325.85作⽤靶点:Isotope-LabeledCompounds;P2YReceptor作⽤通路:Others;GPCR/GProtein储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性(±)-Clopidogrel-d4((±)-Clopidogrelum-d4)氘代标记的(±)-Clopidogrel(HY-107867)。(±)-Clopidogrel⼀种⾎⼩板P2Y12受体抑制剂和⼆磷酸腺苷(ADP)受体拮抗剂。(±)-Clopidogrel可抑制ADP与⾎⼩板细胞膜上受体的结合，并阻断ADP介导的糖蛋⽩GPIIb/IIIa复合物的激活。(±)-Clopidogrel可减轻⾎管炎症和⾎管紧张素II诱发的腹主动脉瘤进展。(±)-Clopidogrel具有抗炎作⽤。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].HagiwaraS,etal.AdenosinediphosphatereceptorantagonistclopidogrelsulfateattenuatesLPS-inducedsystemicinflammationinaratmodel.Shock.2011Mar;35(3):289-92.[2].LiuO,etal.Clopidogrel,aplateletP2Y12receptorinhibitor,reducesvascularinflammationandangiotensinIIinduced-abdominalaorticaneurysmprogression.PLoSOne.2012;7(12):e51707.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02