R-Chloro-butylphthalide-O-NBP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(R)-Chloro-butylphthalide-O-NBPCat.No.:HY-180267分⼦式:C₁₈H₁₇ClO₄分⼦量:332.78作⽤靶点:DrugDerivative作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性(R)-Chloro-butylphthalide-O-NBP⼀种⼿性3-丁邻苯⼆甲酰亚胺衍⽣物，⼀种神经保护剂。(R)-Chloro-butylphthalide-O-NBP具有强⼤的⾎脑屏障(BBB)保护功能。体内实验表明(R)-Chloro-butylphthalide-O-NBP显著减少了梗死体积，并显著保护了BBB的完整性。(R)-Chloro-butylphthalide-O-NBP可⽤于缺⾎性中风的研究[1]。体外研究(R)-Chloro-butylphthalide-O-NBP(compoundR-30)(0.1μM,1μM,10μM)demonstratessignificantimprovementinPC12cellsurvivalunderOGD/Rconditions[1].(R)-Chloro-butylphthalide-O-NBP(0.1μM,1μM,10μM)significantlyreducesLDHreleaseinOGD/R-injuredPC12cells[1].体内研究(R)-Chloro-butylphthalide-O-NBP(compoundR-30)(5-20mg/kg,i.v.)reducesinfarctvolume,improvesneurobehavioralscores,andprotectsBBBintegrityinaratMCAOmodelofischemicstroke[1].Inratstreatedwith(R)-Chloro-butylphthalide-O-NBP(i.v.;100-200mg/kg;once),bodyweight,foodconsumption,postmortemorganweight,andbiochemicalindicatorsremainednormal,withnosignificantabnormalitiesobserved[1].AnimalModel:Sprague-Dawley(SD)rats(middlecerebralarteryocclusion(MCAO)model)[1]Dosage:5mg/kg,10mg/kg,20mg/kgAdministration:i.v.;onceResult:SignificantlyreducedinfarctvolumeandpreservedBBBintegrityinaratMCAOmodel.At10and20mg/kg,significantlyimprovedneurobehavioralscoresandreducedcerebral1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEinfarctionrates.AlsoreducedEvansblue(EB)contentinbraintissue,indicatingprotectionagainstBBBdamage.REFERENCES[1].ShaoL,etal.Novel3-n-butylphthalidederivativesaspotentmulti-functionalanti-ISagentswithBBBprotectivefunction.BioorgChem.2025;167:109237.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82