R-plus-HA-966-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE(R)-(+)-HA-966(Standard)Cat.No.:HY-100822RCASNo.:123931-04-4分子式:C₄H₈N₂O₂分子量:116.12作用靶点:iGluR;ReferenceStandards作用通路:MembraneTransporter/IonChannel;NeuronalSignaling;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性(R)-(+)-HA-966(Standard)是(R)-(+)-HA-966(HY-100822)的分析标准品。本产品用于研究及分析应用。(R)-(+)-HA-966((+)-HA-966)是N-甲基-D-天冬氨酸(NMDA)受体复合物的甘氨酸位点的部分激动剂/拮抗剂。(R)-(+)-HA-966通过苯丙胺选择性阻断中脑边缘多巴胺系统的活化。(R)-(+)-HA-966可透过血脑屏障，有用于神经性和急性疼痛的潜力。IC50&TargetglycinesiteoftheNMDAreceptor[1][2]REFERENCESHutsonPH,etal.R-(+)-HA-966,aglycine/NMDAreceptorantagonist,selectivelyblockstheactivationofthemesolimbicdopaminesystembyamphetamine.BrJPharmacol.1991Aug;103(4):2037-44.WitkinJM,etal.DiscriminativestimuluseffectsofR-(+)-3-amino-1-hydroxypyrrolid-2-one,[(+)-HA-966],apartialagonistofthestrychnine-insensitivemodulatorysiteoftheN-methyl-D-aspartatereceptor.JPharmacolExpTher.1995Dec;275(3):1267-73.ChristensenD,etal.Theantinociceptiveeffectofcombinedsystemicadministrationofmorphineandtheglycine/NMDAreceptorantagonist,(+)-HA966inaratmodelofperipheralneuropathy.BrJPharmacol.1998Dec;125(8):1641-50.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02