RSL3-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemERSL3(Standard)Cat.No.:HY-100218ARCASNo.:1219810-16-8分子式:C₂₃H₂₁ClN₂O₅分子量:440.88作用靶点:p62;GlutathionePeroxidase;ReferenceStandards;Ferroptosis;ReactiveOxygenSpecies(ROS)作用通路:Autophagy;Apoptosis;MetabolicEnzyme/Protease;Others;Immunology/Inflammation;NF-κB储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性RSL3(Standard)是RSL3(HY-100218A)的分析标准品。本产品用于研究及分析应用。RSL3((1S,3R)-RSL3)是一种谷胱甘肽过氧化物酶4(GPX4)的抑制剂(ferroptosis激动剂)，可降低GPX4的表达，诱导头颈部癌细胞的肥大性死亡。在HN3耐受细胞中，可增加p62和Nrf2的蛋白水平，使Keap1灭活[1]。IC50&TargetGlutathioneperoxidase4[1]REFERENCESShinD,etal.Nrf2inhibitionreversesresistancetoGPX4inhibitor-inducedferroptosisinheadandneckcancer.FreeRadicBiolMed.2018Dec;129:454-462.RomaniP,etal.,MitochondrialfissionlinksECMmechanotransductiontometabolicredoxhomeostasisandmetastaticchemotherapyresistance.NatCellBiol.2022Feb;24(2):168-180.ZhangZ,etal.,CGI1746targetsσ1Rtomodulateferroptosisthroughmitochondria-associatedmembranes.NatChemBiol.2024Jan11.ChenT,etal.,Mitochondrialtransplantationrescuesneuronalcellsfromferroptosis.FreeRadicBiolMed.2023Nov1;208:62-72.ZhuJF,etal.,IbrutinibfacilitatesthesensitivityofcolorectalcancercellstoferroptosisthroughBTK/NRF2pathway.CellDeathDis.2023Feb23;14(2):151.SongH,etal.,ApotentGPX4degradertoinduceferroptosisinHT1080cells.EurJMedChem.2024Feb5;265:116110.ZhengJ,etal.,Sorafenibfailstotriggerferroptosisacrossawiderangeofcancercelllines.CellDeathDis.2021Jul13;12(7):698.CheffDM,etal.,TheferroptosisinducingcompoundsRSL3andML162arenotdirectinhibitorsofGPX4butofTXNRD1.RedoxBiol.2023Jun;62:102703.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemELiP,etal.,Inhibitionofcannabinoidreceptortype1sensitizestriple-negativebreastcancercellstoferroptosisviaregulatingfattyacidmetabolism.CellDeathDis.2022Sep21;13(9):808.BrownCW,etal.,Prominin2DrivesFerroptosisResistancebyStimulatingIronExport.DevCell.2019Dec2;51(5):575-586.e4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse