Tesirine-GMP-SG3249-GMP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETesirine(GMP)Cat.No.:HY-128952GCASNo.:1595275-62-9Synonyms:SG3249(GMP)分⼦式:C₇₅H₁₀₁N₉O₂₃分⼦量:1496.65作⽤靶点:Drug-LinkerConjugatesforADC;DNAAlkylator/Crosslinker作⽤通路:Antibody-drugConjugate/ADCRelated;CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tesirine(GMP)(SG3249(GMP))GMP级别的Tesirine(HY-128952)。GMP级别的⼩分⼦可⽤做细胞疗法中的辅助试剂。Tesirine(SG3249)⼀种吡咯苯并⼆氮卓(PBD)⼆聚体，可⽤于合成抗体偶联活性分⼦(ADC)。PBD⼆聚体⼀种⾼效的DNA⼩沟交联剂，具有很强的细胞毒性。Tesirine具有良好的疏⽔性和改进的共轭特性。SG3199(HY-101161)Tesirine系列ADC的有效载荷的释放弹头。SG3199在⼀组癌细胞系中保持⽪IC50&TargetPyrrolobenzodiazepines体外研究Tesirine(SG3199)isthereleasedwarheadcomponentoftheADCpayloadTesirine.TesirineinhibitsK562,NCIN87,BT474,andSKBR3cancercellswithIC50sof150pM,20pM,1nMand320pM[1].户使⽤本产品发表的科研⽂献•Nature.2024Apr;628(8007):416-423.•CellRep.2023Nov28;42(12):113503.•MedDrugDiscov.2025Sep20;28:100226.•bioRxiv.2025Aug21:2025.08.17.670714.•bioRxiv.2024Sep25:2024.09.23.614576.Seemorecustomervalidationsonwww.MedChemE1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEREFERENCES[1].TiberghienAC,etal.DesignandSynthesisofTesirine,aClinicalAntibody-DrugConjugatePyrrolobenzodiazepineDimerPayload.ACSMedChemLett.2016;7(11):983-987.Published2016May24.[2].HartleyJA,etal.Pre-clinicalpharmacologyandmechanismofactionofSG3199,thepyrrolobenzodiazepine(PBD)dimerwarheadcomponentofantibody-drugconjugate(ADC)payloadtesirine.SciRep.2018;8(1):10479.Published2018Jul11.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02