VU0359595-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVU0359595(Standard)Cat.No.:HY-101293RCASNo.:1246303-14-9分⼦式:C₂₅H₂₉BrN₄O₂分⼦量:497.43作⽤靶点:Phospholipase;ReferenceStandards;Fungal作⽤通路:MetabolicEnzyme/Protease;Others;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性VU0359595(Standard)VU0359595(HY-101293)的分析标准品。本产品⽤于研究及分析应⽤。VU0359595(CID-53361951;ML-270)⼀种选择性磷脂酶D1(PLD1)抑制剂，IC50值为3.7nM。VU0359595对PLD1的选择性⽐PLD2(IC50=6.4μM)⾼1700倍以上。VU0359595可⽤于癌症、糖尿病、神经IC50&TargetIC50:3.7nM(PLD1),6.4μM(PLD2)REFERENCES[1].BurkhardtU,etal.PhospholipaseDisatargetforinhibitionofastroglialproliferationbyethanol.Neuropharmacology.2014;79:1-9.[2].TenconiPE,etal.Highglucose-inducedphospholipaseDactivityinretinalpigmentepitheliumcells:Newinsightsintothemolecularmechanismsofdiabeticretinopathy.ExpEyeRes.2019;184:243-257.[3].BermúdezV,etal.Lipopolysaccharide-InducedAutophagyMediatesRetinalPigmentEpitheliumCellsSurvival.ModulationbythePhospholipaseDPathway.FrontCellNeurosci.2019;13:154.Published2019Apr24.[4].LewisJA,etal.Designandsynthesisofisoform-selectivephospholipaseD(PLD)inhibitors.PartI:ImpactofalternativehalogenatedprivilegedstructuresforPLD1specificity.BioorgMedChemLett.2009;19(7):1916-1920.[5].JiaX,etal.GliotoxinpromotesAspergillusfumigatusinternalizationintotypeIIhumanpneumocyteA549cellsbyinducinghostphospholipaseDactivation.MicrobesInfect.2014Jun;16(6):491-501.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5