W-7-hydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEW-7hydrochloride(Standard)Cat.No.:HY-100912RCASNo.:61714-27-0分子式:C₁₆H₂₂Cl₂N₂O₂S分子量:377.33作用靶点:ReferenceStandards;Phosphodiesterase(PDE);Myosin;Apoptosis;Calmodulin;PotassiumChannel作用通路:Others;MetabolicEnzyme/Protease;Cytoskeleton;Apoptosis;MembraneTransporter/IonChannel储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性W-7(hydrochloride)(Standard)是W-7(hydrochloride)(HY-100912)的分析标准品。本产品用于研究及分析应用。W-7hydrochloride是一种选择性的钙调蛋白(calmodulin)拮抗剂。W-7hydrochloride抑制Ca2+-钙调蛋白依赖性磷酸二酯酶(phosphodiesterase)和肌球蛋白轻链激酶(myosinlightchainIC50&TargetIC50:28μM(Phosphodiesterase)and51µM(Myosinlightchainkinase)[1]REFERENCESHHidaka,etal.N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide,aCalmodulinAntagonist,InhibitsCellProliferation.ProcNatlAcadSciUSA.1981Jul;78(7):4354-7.MAsano.DivergentPharmacologicalEffectsofThreeCalmodulinAntagonists,N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide(W-7),ChlorpromazineandCalmidazolium,onIsometricTensionDevelopmentandMyosinLightChainPhosphorylationinIntactBovineTrachealSmoothMuscle.JPharmacolExpTher.1989Nov;251(2):764-73.HItoh,etal.DirectInteractionofCalmodulinAntagonistsWithCa2+/calmodulin-dependentCyclicNucleotidePhosphodiesterase.JBiochem.1984Dec;96(6):1721-6.ShigeyukiYokokura,etal.CalmodulinAntagonistsInduceCellCycleArrestandApoptosisinVitroandInhibitTumorGrowthinVivoinHumanMultipleMyeloma.BMCCancer.2014Nov26;14:882.QuYJ,etal.W-7modulatesKv4.3:poreblockandCa2+-calmodulininhibition.AmJPhysiolHeartCircPhysiol.2007May;292(5):H2364-77.GbadeboTD,etal.CalmodulininhibitorW-7unmasksanovelelectrocardiographicparameterthatpredictsinitiationoftorsadedepointes.Circulation.2002Feb12;105(6):770-4.McePdfHeight1/1 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: