α-δ-NAG-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEα,δ-NAGCat.No.:HY-178978CASNo.:3051899-13-6分⼦式:C₉H₁₄N₂O₅分⼦量:230.22作⽤靶点:DrugDerivative;Phosphatase;ERK;Ras作⽤通路:Others;MetabolicEnzyme/Protease;MAPK/ERKPathway;StemCell/Wnt;GPCR/GProtein储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性α,δ-NAG⼀种具有⼝服活性的抗⾕氨酰胺酶且难⽔解的L-⾕氨酰胺衍⽣物。α,δ-NAG⼀种G蛋⽩偶联受体(GPCR)变构调节剂。α,δ-NAG通过激活GPCR/ERK/MKP-1通路来抑制中性粒细胞性⽓道炎症。α,δ-NAG可⽤于炎症和免疫学研究，如哮喘[1]。体外研究α,δ-NAG(5-20mins)increasesintracellularCa2+,enhancesRasactivity,promotesERKphosphorylationandMKP-1expressioninJ774A.1murinealveolarmacrophagecells[1].体内研究α,δ-NAG(50-200μg/kg,i.g.,5minsbeforethesecondOVAchallenge)suppressesairwayinflammationinOVA(HY-W250978)-inducedasthmamicemodels[1].AnimalModel:OVA-inducedasthmaC57BL/6mice(female,7-8weeksold)[1]Dosage:50,100and200μg/kgAdministration:OralgavageResult:Inhibitedairwayneutrophilandeosinophilinfiltration.ReducedthelevelsofTNF-α,IL-1β(Th1cytokines)andIL-4,IL-5(Th2cytokines)inlungtissue.Improvedairwayhyperresponsiveness(AHR).Decreasedmucussecretionandlungtissueinflammation.REFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].KimJM,etal.α,δ-N-Acetyl-glutamineSuppressesNeutrophilicAirwayInflammationbyActivatingtheGProtein-CoupledReceptor/ExtracellularSignal-RegulatedKinase/Mitogen-ActivatedProteinKinasePhosphatase1Pathway[J].ACSPharmacology&TranslationalScience,2025.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58