CN119409622A 一种苯并咔唑衍生物及其合成方法与应用 （南宁师范大学）

2(1)将(2乙炔基)芳基氮杂环丙烷二酯与取代吲哚在有机溶剂中混合，加入金催化剂炔基)芳基氮杂环丙烷二酯摩尔量的3～10所属路易斯酸催化剂的摩尔量为所述(2一乙3过钯催化在DMF(N,N一二甲基甲酰胺)/DMSO(二甲基咔唑类化合物的高效合成方法对于染料和荧光探针领域具有非常重要的理论意义和实际[0009](1)将(2乙炔基)芳基氮杂环丙烷二酯与取代吲哚在有机溶剂中混合，加入金催4[0017]优选的，上述的苯并咔唑衍生物的合成方法中，所述双金属催化剂体系为环丙烷二酯摩尔量的3～10所属路易斯酸催化剂的摩尔量为所述(2一乙炔基)芳基氮杂环丙烷二酯摩尔量的5～12所述(2一乙炔基)芳基氮杂环丙烷二酯与有机溶剂的比为丙烷二酯摩尔量的5所属路易斯酸催化剂的摩尔量为所述(2一乙炔基)芳基氮杂环丙烷5和设备等均可通过市场购买得到或者可通过现有方法制备得[0029]以下实施例和对比例中反应物一(2一乙炔基)芳基氮杂环丙烷二酯通过以下方法)2Cl263PAuNTf27111.2,110.9,108.0,107.8,67.8,62[0057]HRMS(TOFESI+)m/z:calcdforC8123.4,122.8,112.0,111.1,67.7,62[0077]HRMS(TOF_ESI+)m/z:calcdforC31H29BrN2O6SNa[M+Na]+659.0822,found9[0087]HRMS(TOF_ESI+)m/z:calcdfor[0097]HRMS(TOF_ESI+)m/z:calcdfor[0106]13CNMR(CDCl3,101MHz)δ168.0,166.2,158.3,155.9,143.9,140.8,138.2,135.8,132.5,131.5,128.8,128.4,127.4,125.5,124.2,122.9,122.5,114.3,FNMR[0107]HRMS(TOF_ESI+)m/z:calcdforC30H27FN2O6SNa[M+Na]+599.1623,found[0117]HRMS(TOF_ESI+)m/z:calcdforC37H34N2O7SNa[M+Na]+687.2135,found687.2148.[0127]HRMS(TOF_ESI+)m/z:calcdforC3[0136]13CNMR(CDCl3,101MHz)δ168.0,165.9,144.0,140.6,[0137]HRMS(TOF_ESI+)m/z:calcdforC30H27BrN2O6SNa[M+Na]+659.0822,found659.0833.132.8,131.9,129.5,128.6,127.4,125.8,125.6,124.7,123.4,123.0,113.4,111.2,82.4,[0147]HRMS(TOF_ESI+)m/z:calcdforC30H27IN2O6SK[M+K]+723.0423,found723.0430.[0157]HRMS(TOF_ESI+)m/z:calcdforC31H30N2O6SK[M+K]+611.1613,found611.1618.[0166]13CNMR(CDCl3,101MHz)δ167.9,166.3,153.5,143.8,140.7,136.8,135.9,132.1,[0176]13CNMR(CDCl3,101MHz)δ167.9,166.2,143.9,142.3,[0177]HRMS(TOF_ESI+)m/z:calcdforC36H32N2O6SK[M+K]+673.1769,found673.1770.[0198]13CNMR(101MHz,CDCl3)δ167.9,166.4,149.2,144.0,140.7,136.5,135.9,132.2,110.6,109.7,68.6,62.[0199]HRMS(TOF_ESI+)m/z:calcdforNi(OTf)2Y(OTf)3Yb(OTf)3Cu(OTf)2669号，其中化