2-Methyl-5-acetylphenol-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2-Methyl-5-acetylphenolCat.No.:HY-W152736CASNo.:33414-49-2分⼦式:C₉H₁₀O₂分⼦量:150.17作⽤靶点:DYRK作⽤通路:ProteinTyrosineKinase/RTK储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性2-Methyl-5-acetylphenol⼀种羟化甲苯⼄酮，存在于Cannabissativasubsp.sativa的地上部分。2-Methyl-5-acetylphenol与HIPK2具有良好的结合能⼒。2-Methyl-5-acetylphenol⽆法逆转MPP+(1-methyl-4-phenyl-pyridiniumion)诱导的神经元细胞毒性。2-Methyl-5-acetylphenol可⽤于研究帕⾦森病[1]。IC50&TargetHIPK2体外研究2-Methyl-5-acetylphenol(Compound9)(12.5-100μM;treatmentfor24h)failstoreverseMPP+-inducedcytotoxicityinSH-SY5Ycellsatconcentrationsrangingfrom12.5to100μM;instead,itexacerbatessuchcytotoxicity[1].CellCytotoxicityAssay[1]CellLine:humanneuroblastomaSH-SY5YcellsConcentration:12.5,25,50,100μMIncubationTime:24hResult:Recordedcellviabilityof97.83%,99.78%,98.17%,and96.25%whenappliedaloneat12.5,25,50,and100μM,respectively.Detectedcellviabilityof33.75%,38.41%,38.98%,and39.27%whenappliedincombinationwith1.8mMMPPat12.5,25,50,and100μM,respectively.Calculatedrescueeffectof-24.29%,-13.84%,-12.56%,and-11.91%at12.5,25,50,1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEand100μM,respectively.REFERENCES[1].WangG,etal.AnaturalproductfromCannabissativasubsp.sativainhibitshomeodomain-interactingproteinkinase2(HIPK2),attenuatingMPP-inducedapoptosisinhumanneuroblastomaSH-SY5Ycells.BioorgChem.2017;72:64-73.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589