CN119506367A 一种双酶体系制备氟苯尼考中间体的方法 （上海昱菘生物科技有限公司）

剂的水溶液体系中反应，得到氟苯尼考中间体供一种新的转醛酶与醇脱氢酶双酶体系催化合25.如权利要求4所述的制备方法，其特征在于，所述异丙6.如权利要求1所述的制备方法，其特征在于，所述8.如权利要求1所述的制备方法，其特征在于，还包括以下特征中的一种或多种的组11.一种L苏氨酸转醛酶，其特征在于，所述L苏氨酸转醛酶的氨基酸序列如SEQID3[0005]目前国内外规模化生产(2S,3R)一对甲砜基苯丝氨酸的主要方法是化学合成法和4(2)该反应生产乙醛副产物，为了降低乙醛对反应的抑制作用，还需要添加乙效率，本申请利用双酶体系，通过基因挖掘获得了4个活力较高的转醛酶，转化率可达到99％以上，并通过文献调研，挖掘了1个可以同时高效催化乙醛还原和NADH再生的醇脱氢56小于30个氨基酸并与模板序列identity>40％的序列下载至本地数据库，将两个数据库下[0034]MSNVKQQTAQIVDWLSSTLGKDHQYREDSLSLTANENYPSALVRLTSGSTAGAFYHCSFPFEVPAGEWHFPEPGHMNAIADQVRDLGKTLIGAQAFDWRPNGGSTAEQALMLAACKPGEGFVHFAHRDGGHFALESLAQKMGIEIFHLPVNPTSLLIDVAKLDEMVRRNPHIRIVILDQSFKLRWQPLAEIRSVLPDSCTLTYDMSHDGGLIMGGVFDSPLSCGADIVHGNTHKTIPGPQKGYIGFKSAQHPLLVDTSLWVCPHLQSNCHAEQLPPMWVAFKEMELFGRDYAAQIVSNAKTLARHLHELGLDVTGESFGFTQTHQVHFAVGDLQKALDLCVNSLHAGGIRSTNIEIPGKPGVHGIRLGVQAMTRRGMKEKDFEVVARFIADLYFKKTEPAKVAQQIKEFLQAFPLAPLAYSFDNYLDEELLAAVYQG[0036]ATGTCTAACGTTAAACAGCAGACCGCTCAGATCGTTGACTGGCTGTCTTCTACCCTGGGTAAAGACCACCAGTACCGTGAAGACTCTCTGTCTCTGACCGCTAACGAAAACTACCCGTCTGCTCTGGTTCGTCTGACCTCTGGTTCTACCGCTGGTGCTTTCTACCACTGCTCTTTCCCGTTCGAAGTTCCGGCTGGTGAATGGCACTTCCCGGAACCGGGTCACATGAACGCTATCGCTGACCAGGTTCGTGACCTGGGTAAAACCCTGATCGGCGCGCAGGCGTTCGACTGGCGTCCAAACGGTGGTTCTACCGCTGAACAGGCTCTGATGCTGGCTGCTTGCAAACCGGGTGAAGGTTTCGTTCACTTCGCTCACCGTGACGGTGGTCACTTCGCTCTGGAATCTCTGGCTCAGAAAATGGGTATCGAAATCTTCCACCTGCCGGTTAACCCGACCTCTCTGCTGATCGACGTTGCTAAACTGGACGAAATGGTTCGTCGTAACCCGCACATCCGTATCGTTATCCTGGACCAGTCTTTCAAACTGCGTTGGCAGCCGCTGGCTGAAATCCGTTCTGTTCTGCCGGACTCTTGCACCCTGACCTACGACATGTCTCACGACGGTGGTCTGATCATGGGTGGTGTTTTCGACTCTCCGCTGTCTTGCGGTGCTGACATCGTTCACGGTAACACCCACAAAACCATCCCGGGTCCGCAGAAAGGTTACATCGGTTTCAAATCTGCTCAGCACCCGCTGCTGGTTGACACTTCGCTGTGGGTGTGCCCGCACCTCCAGTCTAACTGCCACGCTGAACAGCTGCCGCCGATGTGGGTTGCTTTCAAAGAAATGGAACTGTTCGGTCGTGACTACGCTGCTCAGATCGTTTCTAACGCTAAAACCCTGGCTCGTCACCTGCACGAACTGGGTCTGGACGTTACCGGTGAATCTTTCGGTTTCACCCAGACCCACCAGGTTCACTTCGCTGTTGGTGACCTGCAGAAAGCTCTGGACCTGTGCGTTAACTCTCTGCACGCTGGTGGTATCCGTTCTACCAACATCGAAATCCCGGGTAAACCGGGTGTTCACGGTATCCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTATGAAAGAAAAAGACTTCGAAGTTGTTGCTCGTTTCATCGCTGACCTGTACTTCAAAAAAACCGAACCGGCTAAAGTTGCTCAGCAGATCAAAGAATTCCTGCAGGCTTTCCCGCTGGCTCCGCTGGCTTACTCTTTCGACAACTACCTGGACGAAGAACTGCTGGCTGCTGTTTACCAGGGTGCTCAGC[0038]MNQHKHNAGPLIEWLAQTLDQDYQYRQDTLSLTANENYPSELVRLTSGSTAGAFYHCSFPFPVPMGEWHFPEPGQMNEIADDLRGLARRMLGAQAFDWRPNGGSPAEQALMLAACKPGEGFVHFAHRDGGHFALEQLASKMGIEIFHLPVDPSSLLIDVARLDDLVRRNPHIRIVILDQSFKLRWQPLAEIRAVLPESCTLTYDMSHDGGLILGGVFDSPLACGADVVHGNTHKTIPGPQKGYIAFKSAQHPLLVDTSMWVCPHLQSNCHAELLPSMWAAFKEMEVFGMAYAQQMVRNAKALANQLHELGLEVSGESFGFTETHQVHFAVGTLQQALAMCVDSLHAGGIRSTNIEIPGKPGVHGIRLGVQAMTRRGMREDDFRQVAGLVADLYFKRTEPARVAARVKELLAGFPLAPLAFSFDGHIDEACRHLIERG7[0040]MKQDESNVGPVIDWLAQTLGQDYKYRQDTLSLTANENYPSELVRLTSGSTAGAFYHCSFPFPVPLGEWHFPEPGQMNEIADDLRGLAKRMMGAQAFDWRPNGGSPAEQALMLAACKQGEGFVHFAHRDGGHFALEQLATKMGIEIFHLPVDPQSLLIDVAKLDDMVRRNPHIRIVILDQSFKLRWQPLAEIRAILPDSCTLTYDMSHDGGLILGGVFDSPLACGADIAHGNTHKTIPGPQKGFIAFKSAQHPLLVETSLWVCPHLQSNCHAELLPSMWAAFKEMEAFGPAYAHQMVRNAKALANQLHELGLNVSGESFGFTETHQVHFAVGDLQQALSMCVDSLHAGGIRSTNIEIPGKPGMHGIRLGVQAMTRRGMKEDDFRRVAGLIADLYFKRTEPARVASKVKELLGDFPLAPLAYSFDQQIDESRRRLLERG[0042]ATGAAACAGGACGAATCTAACGTTGGTCCGGTTATCGACTGGCTGGCTCAGACCCTGGGTCAGGACTACAAATACCGTCAGGACACCCTGTCTCTGACCGCTAACGAAAACTACCCGTCTGAACTGGTTCGTCTGACCTCTGGTTCTACCGCTGGTGCTTTCTACCACTGCTCTTTCCCGTTCCCGGTTCCGCTGGGTGAATGGCACTTCCCGGAACCGGGTCAGATGAACGAAATCGCTGACGACCTGCGTGGTCTGGCTAAACGTATGATGGGTGCTCAGGCTTTCGACTGGCGTCCGAACGGTGGTTCTCCGGCTGAACAGGCTCTGATGCTGGCTGCTTGCAAACAGGGTGAAGGTTTCGTTCACTTCGCTCACCGTGACGGTGGTCACTTCGCTCTGGAACAGCTGGCTACCAAAATGGGTATCGAAATCTTCCACCTGCCGGTTGACCCGCAGTCTCTGCTGATCGACGTTGCTAAACTGGACGACATGGTTCGTCGTAACCCGCACATCCGTATCGTTATCCTGGACCAGTCTTTCAAACTGCGTTGGCAGCCGCTGGCTGAAATCCGTGCTATCCTGCCGGACTCTTGCACCCTGACCTACGACATGTCTCACGACGGTGGTCTGATCCTGGGTGGTGTTTTCGACTCTCCGCTGGCTTGCGGTGCTGACATCGCTCACGGTAACACCCACAAAACCATCCCGGGTCCGCAGAAAGGTTTCATCGCTTTCAAATCTGCTCAGCACCCGCTGCTGGTTGAAACTTCGCTGTGGGTGTGCCCGCACCTCCAGTCTAACTGCCACGCTGAACTGCTGCCGTCTATGTGGGCTGCTTTCAAAGAAATGGAGGCGTTCGGTCCGGCTTACGCTCACCAGATGGTTCGTAACGCTAAAGCTCTGGCTAACCAGCTGCACGAACTGGGTCTGAACGTTAGTGGTGAATCGTTCGGCTTCACCGAAACCCATCAGGTTCACTTCGCTGTTGGTGACCTGCAGCAGGCTCTGTCTATGTGCGTTGACTCTCTGCACGCTGGTGGTATCCGTTCTACCAACATCGAAATCCCGGGTAAACCGGGTATGCACGGTATCCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTATGAAAGAAGACGACTTCCGTCGTGTTGCTGGTCTGATCGCTGACCTGTACTTCAAACGTACCGAACCGGCTCGTGTTGCTTCTAAAGTTAAAGAACTGCTGGGTGACTTCCCGCTGGCTCCGCTGGCTTACTCTTTCGACCAGCAGATCGACGAATCTCGTCGTCGTCTGCTGGAACGTGGTATCCA[0044]MSNVKQQTVQIVDWLSSTLEKDHQYREDSLSLTANENYPSALVRLTSGSTAGAFYHCSFPFAVPAGEWHFPEPGHMNEIADQVRALGKSLIGAQAFDWRPNGGSTAEQALMLAACKPGEGFVHFAHRDGGHFALESLAQKMGIEIFHLPVDPTSLLIDVAKLDHLVRRNPHIRIVILDQSFKLRWQPLDEIRSVLPDSCTLTYDMSHDGGLIMGGVFDSPLNCGADVVHGNTHKTIPGPQKGYIGFKSDQHPLLVDTSLWVCPHLQSNCHAEQLPPMWVAFKEMEVFGRDYAAQIVSNAKTLARHLHELGLDVTGESFGFTQTHQVHFAVGDLQKALDLCVNSLHAGGIRSTNIEIPGKPGVHGIRLGVQAMTRRGMKEKDFEVVARFIADLYFKKTEPARVALQIKEFLQAFPLAPLAYSFDNYLDEELLATVYRG[0046]ATGTCTAACGTTAAACAGCAGACCGTTCAGATCGTTGACTGGCTGTCTTCTACCCTGGAAAAAGACCACCAGTACCGTGAAGACTCTCTGTCTCTGACCGCTAACGAAAACTACCCGTCTGCTCTGGTTCGTCTGACCTCTGGTTCTACCGCTGGTGCTTTCTACCACTGCTCTTTCCCGTTCGCTGTTCCGGCTGGTGAATGGCACTTCCCGGAACCGGGTCACATGAACGAAATCGCTGACCAGGTTCGTGCTCTGGGTAAATCTCTGATAGGCGCTCAGGCGTTCGACTGGCGTCCAAACGGTGGTTCTACCGCTGAACAGGCTCTGATGCTGGCTGCTTGCAAACCGGGTGAAGGTTTCGTTCACTTC8GCTCACCGTGACGGTGGTCACTTCGCTCTGGAATCTCTGGCTCAGAAAATGGGTATCGAAATCTTCCACCTGCCGGTTGACCCGACCTCTCTGCTGATCGACGTTGCTAAACTGGACCACCTGGTTCGTCGTAACCCGCACATCCGTATCGTTATCCTGGACCAGTCTTTCAAACTGCGTTGGCAGCCGCTGGACGAAATCCGTTCTGTTCTGCCGGACTCTTGCACCCTGACCTACGACATGTCTCACGACGGTGGTCTGATCATGGGTGGTGTTTTCGACTCTCCGCTGAACTGCGGTGCTGACGTTGTTCACGGTAACACCCACAAAACCATCCCGGGTCCGCAGAAAGGTTACATCGGTTTCAAATCTGACCAGCACCCGCTGCTGGTTGACACTTCGCTGTGGGTGTGCCCGCACCTCCAGTCTAACTGCCACGCTGAACAGCTGCCGCCGATGTGGGTTGCTTTCAAAGAAATGGAAGTTTTCGGTCGTGACTACGCTGCTCAGATCGTTTCTAACGCTAAAACCCTGGCTCGTCACCTGCACGAACTGGGTCTGGACGTTACCGGTGAATCTTTCGGTTTCACCCAGACCCACCAGGTTCACTTCGCTGTTGGTGACCTGCAGAAAGCTCTGGACCTGTGCGTTAACTCTCTGCACGCTGGTGGTATCCGTTCTACCAACATCGAAATCCCGGGTAAACCGGGTGTTCACGGTATCCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTATGAAAGAAAAAGACTTCGAAGTTGTTGCTCGTTTCATCGCTGACCTGTACTTCAAAAAAACCGAACCGGCTCGTGTTGCTCTGCAGATCAAAGAATTCCTGCAGGCTTTCCCGCTGGCTCCGCTGGCTTACTCTTTCGACAACTACCTGGACGAAGAACTGCTGGCTACCGTTTACCGTGGTACCCAGCGTT[0048]MNQDKHNAGPLIEWLAQTLDQDYQYRQDTLSLTANENYPSELVRLTSGSTAGAFYHCSFPFPVPLGEWHFPEPGQMNEIADDLRGLARRMLGAQAFDWRPNGGSPAEQALMLAACKPGEGFVHFAHRDGGHFALEQLASKMGIEIFHLPVDPRSLLIDVAKLDDMVRRNPHIRIVILDQSFKLRWQPLAEIRAVLPESCALTYDMSHDGGLILGGVFDSPLACGADAVHGNTHKTIPGPQKGYIAFKSAQHPLLVDTSMWVCPHLQSNCHAELLPSMWAAFKEMEVFGMAYAQQMVKNAKSLAQQLHELGLEVSGESFGFTETHQVHFAVGTLQQALAMCVDSLHAGGIRSTNIEIPGKPGVHGIRLGVQAMTRRGMREDDFRQVAGLVADLYFKRTEPARVANRVKELLAGFPLAPLAYSFDGQIDEAHRHLIERG[0050]ATGAACCAGGACAAACACAACGCTGGTCCGCTGATCGAATGGCTGGCTCAGACCCTGGACCAGGACTACCAGTACCGTCAGGACACCCTGTCTCTGACCGCTAACGAAAACTACCCGTCTGAACTGGTTCGTCTGACCTCTGGTTCTACCGCTGGTGCTTTCTACCACTGCTCTTTCCCGTTCCCGGTTCCGCTGGGTGAATGGCACTTCCCGGAACCGGGTCAGATGAACGAAATCGCTGACGACCTGCGTGGTCTGGCTCGTCGTATGCTGGGTGCTCAGGCTTTCGACTGGCGTCCGAACGGTGGTTCTCCGGCTGAACAGGCTCTGATGCTGGCTGCTTGCAAACCGGGTGAAGGTTTCGTTCACTTCGCTCACCGTGACGGTGGTCACTTCGCTCTGGAACAGCTGGCTTCTAAAATGGGTATCGAAATCTTCCACCTGCCGGTTGACCCGCGTTCTCTGCTGATCGACGTTGCTAAACTGGACGACATGGTTCGTCGTAACCCGCACATCCGTATCGTTATCCTGGACCAGTCTTTCAAACTGCGTTGGCAGCCGCTGGCTGAAATCCGTGCTGTTCTGCCGGAATCTTGCGCTCTGACCTACGACATGTCTCACGACGGTGGTCTGATCCTGGGTGGTGTTTTCGACTCTCCGCTGGCTTGCGGTGCTGACGCTGTTCACGGTAACACCCACAAAACCATCCCGGGTCCGCAGAAAGGTTACATCGCTTTCAAATCTGCTCAGCACCCGCTGCTGGTTGACACTTCGATGTGGGTGTGCCCGCACCTCCAGTCTAACTGCCACGCTGAACTGCTGCCGTCTATGTGGGCTGCTTTCAAAGAAATGGAAGTTTTCGGTATGGCTTACGCTCAGCAGATGGTTAAAAACGCTAAATCTCTGGCTCAGCAGCTGCACGAACTGGGTCTGGAAGTTTCTGGTGAATCGTTTGGCTTCACCGAAACCCATCAGGTTCACTTCGCTGTTGGTACCCTGCAGCAGGCTCTGGCTATGTGCGTTGACTCTCTGCACGCTGGTGGTATCCGTTCTACCAACATCGAAATCCCGGGTAAACCGGGTGTTCACGGTATCCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTATGCGTGAAGACGACTTCCGTCAGGTTGCTGGTCTGGTTGCTGACCTGTACTTCAAACGTACCGAACCGGCTCGTGTTGCTAACCGTGTTAAAGAACTGCTGGCTGGTTTCCCGCTGGCTCCGCTGGCTTACTCTTTCGACGGTCAGATCGACGAAGCTCACCGTCACCTGATCGAACGTGGTATCCAGCGTT9[0052]MTRTTPQARHVVERLNSVLGQDYRYREDCLSLTANENYPSALVRLAGSATAGAFYHCSFPFEVPPGEWYFPESGRMGELAQQLNELGRSLLGAGTFDWRPNGGSPAEQALMLAACKHGEGMVHFAHRDGGHFALENLAQKAGIDIFHLPVDPQTLLIDVARLDELVRRNPQIRIVILDQSFKLRWQPLAAIRKVLPPSCTLTYDTSHDGGLIMGGVFDSPLHCGADVIHGNTHKTVPGPQKGYIAFKSAEHPLLVDTSLWLCPHLQSNCHAELLPPMWVAFKEMEAFGHDYAPQVARNAKALAGHLHRLGFEVSGEAFGFTETHQVHFAVGDLQQALDLCMNTLHRGGIRSTNIEIPGKPGIQGIRLGVQAMTRRGLREDDFEQVARFIADLHFRKADPAGVAAQVAEFLRAFPLAPLHYSFDQELDHELLQSLI[0054]ATGACCCGTACCACCCCGCAGGCTCGTCACGTTGTTGAACGTCTGAACTCTGTTCTGGGTCAGGACTACCGTTACCGTGAAGACTGCCTGTCTCTGACCGCTAACGAAAACTACCCGTCTGCTCTGGTTCGTCTGGCTGGTTCTGCTACCGCTGGTGCTTTCTACCACTGCTCTTTCCCGTTCGAAGTTCCGCCGGGTGAATGGTACTTCCCGGAATCTGGTCGTATGGGTGAACTGGCTCAGCAGCTGAACGAACTGGGTCGTTCTCTGCTGGGTGCTGGTACCTTCGACTGGCGTCCGAACGGTGGTTCTCCGGCTGAACAGGCTCTGATGCTGGCTGCTTGCAAACACGGTGAAGGTATGGTTCACTTCGCTCACCGTGACGGTGGTCACTTCGCTCTGGAAAACCTGGCTCAGAAAGCTGGTATCGACATCTTCCACCTGCCGGTTGACCCGCAGACCCTGCTGATCGACGTTGCTCGTCTGGACGAACTGGTTCGTCGTAACCCGCAGATCCGTATCGTTATCCTGGACCAGTCTTTCAAACTGCGTTGGCAGCCGCTGGCTGCTATCCGTAAAGTTCTGCCGCCGTCTTGCACCCTGACCTACGACACCTCTCACGACGGTGGTCTGATCATGGGCGGTGTATTCGACAGCCCGCTGCACTGCGGTGCTGACGTTATCCACGGTAACACCCACAAAACCGTTCCGGGTCCGCAGAAAGGTTACATCGCTTTCAAATCTGCTGAACACCCGCTGCTGGTTGACACCTCTCTGTGGCTGTGCCCGCACCTGCAGTCTAACTGCCACGCTGAACTGCTGCCGCCGATGTGGGTTGCTTTCAAAGAAATGGAGGCGTTCGGTCACGACTACGCTCCGCAGGTTGCTCGTAACGCTAAAGCTCTGGCTGGTCACCTGCACCGTCTGGGTTTCGAAGTTTCTGGGGAGGCGTTCGGCTTCACCGAGACCCATCAGGTTCACTTCGCTGTTGGTGACCTGCAGCAGGCTCTGGACCTGTGCATGAACACCCTGCACCGTGGTGGTATCCGTTCTACCAACATCGAAATCCCGGGTAAACCGGGTATCCAGGGTATCCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTCTGCGTGAAGACGACTTCGAACAGGTTGCGAGGTTCATCGCTGACCTCCACTTCCGTAAAGCTGACCCGGCTGGTGTTGCTGCTCAGGTTGCTGAATTCCTGCGTGCTTTCCCGCTGGCTCCGCTGCACTACTCTTTCGACCAGGAACTGGACCACGAACTGCTGCAGTCTCTGATCGGTGAAGCTCTGC[0056]MKQEPTGAFEVATVLNDIFSADHRYREATLSLTANENYPSELVRVTSGSTAGAFYHVSFPFDVPDGEWHFPEPGHMHAVADKVRSLGKSLLHAQTFDWRPNGGSAAEQALMLAACQPGDGFVHFAHGDGGHFALEALASKAGIEIFHLPVDPDTLLIDVDRLAALVDAHPRIRIVILDQSFKLRWQPLRAIRDALPAHCTLTYDASHDGGLVMGGWFDSPLRCGADIVHGNTHKTIAGPQKAYIAFGSAEHPLLADTSIWVCPNIQSNCHAEQLPSMWVALKEIEVYGLAYASQVVRNAAALARALHARGLDVSGESFGFTETHQVHFSVGTPEDALLTCRDILHRGGIRTTNIELPGKPGMHGIRLGVQAMTRRGMVERDFETAADFIAALCTRKRTPEEVAPDVATFLGDFPLSPLAFSFDSGMTDALRAALRQG[0058]MTDFTQAVVNPFVDEQRKGRLAEKISNIFDVLHSDFALDNLYRASHLSLTASENYPSKFVRTMGAGMQGGFYEFAPPYAANPGEWYFPDSGAQGSLVEKLASLGKQLFEANSFDWRPNGGSAAEQAVLLGTCARGDGFVHFAHKDGGHFALEELAQKIGVSIFHLPIEEKSLLIDVNRLASLIKDNPHIKLVILDQSFKLRWQPLLQIRQALPESIVLSYDASHDGGLIIGECLPQPLLFGADIVHGNTHKTIPGPQKGYIAFKDADHPAMKQVSDWVCPHLQSNSHAELIAPMYIALVEMSLYGRSYAEQVIKNAKALAHALHAEGARVSGESFGFTETHQVHVVVGAERKALELVTGTLALAGIRCNNIEIPGANGLFGLRLGVQALTRRGIKEHGMAEVARFLVRLILKNEAPTAIRDEIASFLESYPINTLHYSLDAHYYTPSG[0060]ATGACCGACTTCACCCAGGCTGTTGTTAACCCGTTCGTTGACGAACAGCGTAAAGGTCGTCTGGCTGAAAAAATCTCTAACATCTTCGACGTTCTGCACTCTGACTTCGCTCTGGACAACCTGTACCGTGCTTCTCACCTGTCTCTGACCGCTTCTGAAAACTACCCGTCTAAATTCGTTCGTACCATGGGTGCTGGTATGCAGGGTGGTTTCTACGAATTCGCTCCGCCGTACGCTGCTAACCCGGGTGAATGGTACTTCCCGGACTCTGGTGCTCAGGGTTCTCTGGTTGAAAAACTGGCTTCTCTGGGTAAACAGCTGTTCGAAGCTAACTCTTTCGACTGGCGTCCGAACGGTGGTTCTGCTGCTGAACAGGCTGTTCTGCTGGGTACCTGCGCTCGTGGTGACGGTTTCGTTCACTTCGCTCACAAAGACGGTGGTCACTTCGCTCTGGAAGAACTGGCTCAGAAAATCGGTGTTTCTATCTTCCACCTGCCGATCGAAGAAAAATCTCTGCTGATCGACGTTAACCGTCTGGCTTCTCTGATCAAAGACAACCCGCACATCAAACTGGTAATCCTCGACCAGAGCTTCAAACTGCGTTGGCAGCCGCTGCTGCAGATCCGTCAGGCTCTGCCGGAATCTATCGTTCTGTCTTACGACGCTTCTCACGACGGTGGTCTGATCATCGGTGAATGCCTGCCGCAGCCGCTGCTGTTCGGTGCTGACATCGTTCACGGTAACACCCACAAAACCATCCCGGGTCCGCAGAAAGGTTACATCGCTTTCAAAGACGCTGACCACCCGGCTATGAAACAGGTTTCTGACTGGGTTTGCCCGCACCTGCAGTCTAACTCTCACGCTGAACTGATCGCTCCGATGTACATCGCTCTGGTTGAAATGTCTCTGTACGGTCGTTCTTACGCTGAACAGGTTATCAAAAACGCTAAAGCTCTGGCTCACGCTCTGCACGCTGAAGGTGCTCGTGTTTCTGGTGAATCTTTCGGTTTCACCGAAACCCACCAGGTTCACGTTGTTGTTGGTGCTGAACGTAAAGCTCTGGAACTGGTTACCGGTACCCTGGCTCTGGCTGGTATCCGTTGCAACAACATCGAAATCCCGGGTGCTAACGGTCTGTTCGGTCTGCGTCTGGGTGTTCAGGCTCTGACCCGTCGTGGTATCAAAGAACACGGTATGGCTGAAGTTGCTCGTTTCCTGGTTCGTCTGATCCTGAAAAACGAAGCTCCGACCGCTATCCGTGACGAAATCGCTTCTTTCCTGGAATCTTACCCGATCAACACCCTGCACTACTCTCTGGACGCTCACTACTACACCCCGTCTGGTATCAAACTGATGGAAG[0062]MRAAEQDSGVGLVDDGAQAAVEAAEEIIEEASGGDGGVFAPAWSDDRVAHLLERLTSDFVLDNTYREQHLSLTASENYPSKLVRMLGSALQGGFYEFAPPYPTEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGTCGRGDGFVHFAHKDGGHFALESLAAAAGVNTYHLPMVDRTLLIDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQIRAALPEGVFLAYDASHDGALIAGGALPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDADHPRLRAVSDWVCPQMQSNSHAELIAPMYVALSEIALYGHDYARQILANAKALAHALHEEGVRVSGESFGFTETHQVHLVTGSAADALRLALGDLAHAGIRTTNIEVPGANGLHGLRLGVQAMTRRGLRETEMREVARLVAKVVLRRAEPTTVRAEVADLLQSHPLDRLAFSFDSHVESPAAARLLGEV[0064]ATGCGTGCTGCTGAACAGGACTCTGGTGTTGGTCTGGTTGACGACGGTGCTCAGGCTGCTGTTGAAGCTGCTGAAGAAATCATCGAAGAAGCTTCTGGTGGTGACGGTGGTGTTTTCGCTCCGGCTTGGTCTGACGACCGTGTTGCTCACCTGCTGGAACGTCTGACCTCTGACTTCGTTCTGGACAACACCTACCGTGAACAGCACCTGTCTCTGACCGCTTCTGAAAACTACCCGTCTAAACTGGTTCGTATGCTGGGTTCTGCTCTGCAGGGTGGTTTCTACGAATTCGCTCCGCCGTACCCGACCGAAGCTGGTGAATGGGCTTTCCCGGACTCTGGTGCTAACGCTTCTCTGGTTGGTAAACTGACCGGTATCGGTCGTCAGCTGTTCGAAGCTGCTACCTTCGACTGGCGTCCGAACGGTGGTTCTGTTGCTGAACAGGCTGTTCTGCTGGGTACCTGCGGCCGTGGTGACGGCTTCGTTCACTTCGCGCACAAAGACGGTGGTCACTTCGCTCTGGAATCTCTGGCTGCTGCTGCTGGTGTTAACACCTACCACCTGCCGATGGTTGACCGTACCCTGCTGATCGACGTTGACCGTCTGGCTACCCTGTGCGCTGAACACCCGGAAATCAAACTGGTAATCCTCGACCAGAGCTTCAAACTGCGTTGGCAGCCGCTGGCTCAGATCCGTGCTGCTCTGCCGGAAGGTGTTTTCCTGGCTTACGACGCTTCTCACGACGGTGCTCTGATCGCTGGTGGTGCTCTGCCGCAGCCGACCCTGCTGGGTGCTGACGCTGTTCACGGTAACACCCACAAAACCATCGCTGGTCCGCAGAAAGCTTACATCGCTTTCCGTGACGCTGACCACCCGCGTCTCCGTGCTGTAAGCGACTGGGTTTGCCCGCAGATGCAGTCTAACTCTCACGCTGAACTGATCGCTCCGATGTACGTTGCTCTGTCTGAAATCGCTCTGTACGGTCACGACTACGCTCGTCAGATCCTGGCTAACGCTAAAGCTCTGGCTCACGCTCTGCACGAAGAAGGCGTTCGTGTAAGCGGTGAATCTTTCGGTTTCACCGAAACCCACCAGGTTCACCTGGTTACCGGTTCTGCTGCTGACGCTCTGCGTCTGGCTCTGGGTGACCTGGCTCACGCTGGTATCCGTACCACCAACATCGAAGTTCCGGGTGCTAACGGTCTGCACGGTCTGCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTCTGCGTGAAACCGAAATGCGTGAAGTTGCTCGTCTGGTTGCTAAAGTTGTTCTGCGTCGTGCTGAACCGACCACCGTTCGTGCTGAAGTTGCTGACCTGCTGCAGTCTCACCCGCTGGACCGTCTCGCGTTCTCTTTCGACTCGCACGTTGAATCTCCGGCTGCTGCTCGTCTGCTGGGTGAAGTTTT[0066]MRAAEQDSGIGLVDDEAQAAVVAAEGIIEKASGGDSGGEFGPVWSDDRVAHLLERLASDFVLDNTYREQHLSLTASENYPSKLVRMLGSGLQGGFYEFAPPYPAEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGTCGRGDGFVHFAHKDGGHFALEALAGAAGVNTYHLPMVDRTLLVDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQIRAALPEGVFLAYDASHDGALIAGGALPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDADHPKLRAVSDWVCPQMQSNSHAELIAPMYVALSEIALYGHDYARQILANSKALAHALHEEGVRVSGESFGFTETHQVHVITGSAADALRLSLGDLAHAGIRTTNIEVPGANGLHGLRLGVQAMTRRGLREAEMREVARLVAKVVLRRAEPTTVRAEVADLLQDHALDRLAYSFDAYVDSPAAARLLGEV[0068]ATGCGTGCTGCTGAACAGGACTCTGGTATCGGTCTGGTTGACGACGAAGCTCAGGCTGCTGTTGTTGCTGCTGAAGGTATCATCGAAAAAGCTTCTGGTGGTGACTCTGGTGGTGAATTCGGTCCGGTTTGGTCTGACGACCGTGTTGCTCACCTGCTGGAACGTCTGGCTTCTGACTTCGTTCTGGACAACACCTACCGTGAACAGCACCTGTCTCTGACCGCTTCTGAAAACTACCCGTCTAAACTGGTTCGTATGCTGGGTTCTGGTCTGCAGGGTGGTTTCTACGAATTCGCTCCGCCGTACCCGGCTGAAGCTGGTGAATGGGCTTTCCCGGACTCTGGTGCTAACGCTTCTCTGGTTGGTAAACTGACCGGTATCGGTCGTCAGCTGTTCGAAGCTGCTACCTTCGACTGGCGTCCGAACGGTGGTTCTGTTGCTGAACAGGCTGTTCTGCTGGGTACCTGCGGCCGTGGTGACGGCTTCGTTCACTTCGCGCACAAAGACGGTGGTCACTTCGCTCTGGAAGCTCTGGCTGGTGCTGCTGGTGTTAACACCTACCACCTGCCGATGGTTGACCGTACCCTGCTGGTTGACGTTGACCGTCTGGCTACCCTGTGCGCTGAACACCCGGAAATCAAACTGGTAATCCTCGACCAGAGCTTCAAACTGCGTTGGCAGCCGCTGGCTCAGATCCGTGCTGCTCTGCCGGAAGGTGTTTTCCTGGCTTACGACGCTTCTCACGACGGTGCTCTGATCGCTGGTGGTGCTCTGCCGCAGCCGACCCTGCTGGGTGCTGACGCTGTTCACGGTAACACCCACAAAACCATCGCTGGTCCGCAGAAAGCTTACATCGCTTTCCGTGACGCTGACCACCCGAAACTGCGTGCTGTTTCTGACTGGGTTTGCCCGCAGATGCAGTCTAACTCTCACGCTGAACTGATCGCTCCGATGTACGTTGCTCTGTCTGAAATCGCTCTGTACGGTCACGACTACGCTCGTCAGATCCTGGCTAACTCTAAAGCTCTGGCTCACGCTCTGCACGAAGAAGGCGTTCGTGTAAGCGGTGAATCTTTCGGTTTCACCGAAACCCACCAGGTTCACGTTATCACCGGTTCTGCTGCTGACGCTCTGCGTCTGTCTCTGGGTGACCTGGCTCACGCTGGTATCCGTACCACCAACATCGAAGTTCCGGGTGCTAACGGTCTGCACGGTCTGCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTCTGCGTGAAGCTGAAATGCGTGAAGTTGCTCGTCTGGTTGCTAAAGTTGTTCTGCGTCGTGCTGAACCGACCACCGTTCGTGCTGAAGTTGCTGACCTGCTGCAGGACCACGCTCTGGACCGTCTGGCTTACTCTTTCGACGCTTACGTTGACTCTCCGGCTGCTGCTCGTCTGCTGGGTGAAGT[0070]MGLEAVEAEAEAIVEDAVDAEGVWAGDRVAQVLERLASDFVLDNTYREQHLSLTASENYPSKLVRMLGAGLQGGFYEFAPPYPAEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGTCGRGDGFVHFAHKDGGHFALESLAGAAGINTYHLPMVDRTLLIDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQLRAALPAGVFLAYDASHDGALIAGGALPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDAEHPKLKAVSDWVCPQMQSNSHAELIAPMYVALSEVALYGHAYARQILANAQALAHGLHEEGVRVSGESFGFTETHQVHVVTGSAADALRLSLGELARAGIRTTNIEVPGANGLHGLRLGVQAMTRRGLREPQMREVARLVAKVVLRRAEPAAVRAEVADLLQHHPLDRLAYSFDSYVD[0072]ATGGGTCTGGAAGCTGTTGAAGCTGAAGCTGAAGCTATCGTTGAAGACGCTGTTGACGCTGAAGGTGTTTGGGCTGGTGACCGTGTTGCTCAGGTTCTGGAACGTCTGGCTTCTGACTTCGTTCTGGACAACACCTACCGTGAACAGCACCTGTCTCTGACCGCTTCTGAAAACTACCCGTCTAAACTGGTTCGTATGCTGGGTGCTGGTCTGCAGGGTGGTTTCTACGAATTCGCTCCGCCGTACCCGGCTGAAGCTGGTGAATGGGCTTTCCCGGACTCTGGTGCTAACGCTTCTCTGGTTGGTAAACTGACCGGTATCGGTCGTCAGCTGTTCGAAGCTGCTACCTTCGACTGGCGTCCGAACGGTGGTTCTGTTGCTGAACAGGCTGTTCTGCTGGGTACCTGCGGCCGTGGTGACGGCTTCGTTCACTTCGCGCACAAAGACGGTGGTCACTTCGCTCTGGAATCTCTGGCTGGTGCTGCTGGTATCAACACCTACCACCTGCCGATGGTTGACCGTACCCTGCTGATCGACGTTGACCGTCTGGCTACCCTGTGCGCTGAACACCCGGAAATCAAACTGGTAATCCTCGACCAGAGCTTCAAACTGCGTTGGCAGCCGCTGGCTCAGCTGCGTGCTGCTCTGCCAGCGGGTGTCTTCCTGGCATACGACGCTTCTCACGACGGTGCTCTGATCGCTGGTGGTGCTCTGCCGCAGCCGACCCTGCTGGGTGCTGACGCTGTTCACGGTAACACCCACAAAACCATCGCTGGTCCGCAGAAAGCTTACATCGCTTTCCGTGACGCTGAACACCCGAAACTGAAAGCTGTTTCTGACTGGGTTTGCCCGCAGATGCAGTCTAACTCTCACGCTGAACTGATCGCTCCGATGTACGTTGCTCTGTCTGAAGTTGCTCTGTACGGTCACGCTTACGCTCGTCAGATCCTGGCTAACGCTCAGGCTCTGGCTCACGGTCTGCACGAAGAAGGCGTTCGTGTATCGGGGGAATCGTTCGGCTTCACCGAGACCCATCAGGTTCACGTTGTTACCGGTTCTGCTGCTGACGCTCTGCGTCTGTCTCTGGGTGAACTGGCTCGTGCTGGTATCCGTACCACCAACATCGAAGTTCCGGGTGCTAACGGTCTGCACGGTCTGCGTCTGGGTGTTCAGGCTATGACCCGTCGTGGTCTGCGTGAACCGCAGATGCGTGAAGTTGCTCGTCTGGTTGCTAAAGTTGTTCTGCGTCGTGCTGAACCGGCTGCTGTTCGTGCTGAAGTTGCTGACCTGCTGCAGCACCACCCGCTGGACCGTCTGGCTTACTCTTTCGACTCTTACGTTGACTCTCCGGCTGCTGCTCGTCTGCTGGGTGAAGTTTTCC[0074]MVDDGTVLVDDEAKAAVEAAEGIIEEASGSDDGTFGEAAWADDRVAHLLERLTSDFVLDNTYREQHLSLTASENYPSRLVRMLGSGLQGGFYEFAPPYQAEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGTCGRGDGFVHFAHKDGGHFALESLAAAAGVNTYHLPMVDRTLLIDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQIRAALPEGVFLAYDASHDGALIAGGALPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDAEHPKLKAVSDWVCPQMQSNSHAELIAPMYVALSEIALYGHDYARQILANAKALAHGLHEEGVRVSGESFGFTETHQVHVVTGSAADALRLSLGDLAHAGIRTTNIEVPGANGLHGLRLGVQAMTRRGLREAEMREVARLVAKVVLRRAEPTAVRAEVADLLQHHTLDQLAYSFDAYVDSPAAARLLGEVF[0076]MAVYDRAGASSLRSARADQLPTETHAGDGKLLGWLAGVLAQDRHYHTVMATLTASENYPSAVVRAAAAFFGGEHYFFDAPSPGHCGEWSFPRSATLPALQTKFLAQMKRLFAADIADWRPNGGSMCEQAVVMAACKGGDAFVELAPEDGGHFGASVLAERLGIESFAFPMHGDLIDVEGTVRLVKEHPSIRLLLVQPSHCRRPQPIEELASAMPRQIVLAVDVSHTAGLIAAGLLPQPLLQGADILTFNTHKTLPGPNKGVIAFADGDHPLAHTMWETVCPQLQSNSHAECLPGLVIALEEIANFGRAYGEQVIANARTLAHVLDSNGLSVPGMEYGGTETHQVHVRLGAAEVANRVANELLPTCGIRTNSVLIPGTGGEFGLRLGTQALTRRGLTEIEFAKLGRLLARAVRWTADVGQIRHEVAELLADHPLFPLRFSFDESAYGQQ[0078]ATGGCTGTTTACGACCGTGCTGGTGCTTCTTCTCTGCGTTCTGCTCGTGCTGACCAGCTGCCGACCGAAACCCACGCTGGTGACGGTAAACTGCTGGGTTGGCTGGCTGGTGTTCTGGCTCAGGACCGTCACTACCACACCGTTATGGCTACCCTGACCGCTTCTGAAAACTACCCGTCTGCTGTTGTTCGTGCTGCTGCTGCGTTCTTCGGTGGTGAGCACTACTTCTTCGACGCTCCGTCTCCGGGTCACTGCGGTGAATGGTCTTTCCCGCGTTCTGCTACCCTGCCGGCTCTGCAGACCAAATTCCTGGCTCAGATGAAACGTCTGTTCGCTGCTGACATCGCTGACTGGCGTCCGAACGGTGGTTCTATGTGCGAACAGGCTGTTGTTATGGCTGCTTGCAAAGGTGGTGACGCTTTCGTTGAACTGGCTCCGGAAGACGGTGGTCACTTCGGTGCTTCTGTTCTGGCTGAACGTCTGGGTATAGAATCGTTCGCGTTCCCGATGCACGGCGACCTGATCGACGTTGAAGGTACCGTTCGTCTGGTTAAAGAACACCCGTCTATCCGTCTGCTGCTGGTTCAGCCGTCTCACTGCCGTCGTCCGCAGCCGATCGAAGAACTGGCTTCTGCTATGCCGCGTCAGATCGTTCTGGCTGTTGACGTTTCTCACACCGCTGGTCTGATCGCTGCTGGTCTGCTGCCGCAGCCGCTGCTGCAGGGTGCTGACATCCTGACCTTCAACACCCACAAAACCCTGCCGGGTCCGAACAAAGGTGTTATCGCTTTCGCTGACGGTGACCACCCGCTGGCTCACACCATGTGGGAAACCGTTTGCCCGCAGCTGCAGTCTAACTCTCACGCTGAATGCCTGCCGGGTCTGGTTATCGCTCTGGAAGAAATCGCTAACTTCGGTCGTGCTTACGGTGAACAGGTTATCGCTAACGCTCGTACCCTGGCTCACGTTCTGGACTCTAACGGTCTGTCTGTTCCGGGTATGGAATACGGTGGTACCGAAACCCACCAGGTTCACGTTCGTCTGGGTGCTGCTGAAGTTGCTAACCGTGTTGCTAACGAACTGCTGCCGACCTGCGGTATCCGTACCAACTCTGTTCTGATCCCGGGTACCGGTGGTGAATTCGGTCTGCGTCTGGGTACCCAGGCTCTGACCCGTCGTGGTCTGACCGAAATCGAATTCGCTAAACTGGGTCGTCTGCTGGCTCGTGCTGTTCGTTGGACCGCTGACGTTGGTCAGATCCGTCACGAAGTTGCTGAACTGCTGGCTGACCACCCGCTGTTTCCACTGAGGTTCTCTTTCGACGAGTCTGCTTACGGTCAGCAGCTGGAACGTATGCTGG[0080]MKISTKTNNKGSVYNRTTPVKSSSLEPKIAKFFGAVTQHLASDNLYRKDMLSLTASENYQSFLVRMLSSSHNSSFYSFIPPYNVESAGEEWFFPDSDSRKEITALLRETGKAMFHSQTFDERPNGGSGAEQAVLLATCNRGDGWLHFSAQDGGHFGNEALSIKAGLEEHHFPVDPTTGLIKIEELNTILKKHQNIKLLLLDQSHKLRYQPLAEIKKLLQPDVLLAYDCSHDMGLIVGGSLPQPLLEGADVLIGNTHKTFPSVNKAIIAFADKNHPLFKPVSDWVCPFLQSNSHHELTLPLLISLMEMKVFGKDYAEQTVKNAKAFAKELREQGFNVSGEHFCYTKTHQVHLILDSRQEALKAVSELLPSAGIRGNNIMIPGHNAFGLRLGTQAITRRGMKEEEMREVAKFLAKVLLKKENPTKIKAEVKELLMDFSLFPLAYSFDFLV[0082]ATGAAAATCTCTACCAAAACCAACAACAAAGGTTCTGTTTACAACCGTACCACCCCGGTTAAATCTTCTTCTCTGGAACCGAAAATCGCTAAATTCTTCGGTGCTGTTACCCAGCACCTGGCTTCTGACAACCTGTACCGTAAAGACATGCTGTCTCTGACCGCTTCTGAAAACTACCAGTCTTTCCTGGTTCGTATGCTGTCTTCTTCTCACAACTCTTCTTTCTACTCTTTCATCCCGCCGTACAACGTTGAATCTGCTGGTGAAGAATGGTTCTTCCCGGACTCTGACTCTCGTAAAGAAATCACCGCTCTGCTGCGTGAAACCGGTAAAGCTATGTTCCACTCTCAGACCTTCGACGAACGTCCGAACGGTGGTTCTGGTGCTGAACAGGCTGTTCTGCTGGCTACCTGCAACCGTGGTGACGGTTGGCTGCACTTCTCTGCTCAGGACGGTGGTCACTTCGGTAACGAAGCTCTGTCTATCAAAGCTGGTCTGGAAGAACACCACTTCCCGGTTGACCCGACCACCGGTCTGATCAAAATCGAAGAACTGAACACCATCCTGAAAAAACACCAGAACATCAAACTGCTGCTGCTGGACCAGTCTCACAAACTGCGTTACCAGCCGCTGGCTGAAATCAAAAAACTGCTGCAGCCGGACGTTCTGCTGGCTTACGACTGCTCTCACGACATGGGTCTGATCGTTGGTGGTTCTCTGCCGCAGCCGCTGCTGGAAGGTGCTGACGTTCTGATCGGTAACACCCACAAAACCTTCCCGTCTGTTAACAAAGCTATCATCGCTTTCGCTGACAAAAACCACCCGCTGTTCAAACCGGTATCGGACTGGGTGTGCCCATTCCTGCAGTCTAACTCTCACCACGAACTGACCCTGCCGCTGCTGATCTCTCTGATGGAAATGAAAGTTTTCGGTAAAGACTACGCTGAACAGACCGTTAAAAACGCTAAAGCTTTCGCTAAAGAACTGCGTGAACAGGGTTTCAACGTTTCTGGTGAACACTTCTGCTACACCAAAACCCACCAGGTTCACCTGATCCTGGACTCTCGTCAGGAAGCTCTGAAAGCTGTTTCTGAACTGCTGCCGTCTGCTGGTATCCGTGGTAACAACATCATGATCCCGGGTCACAACGCTTTCGGTCTGCGTCTGGGTACCCAGGCTATCACCCGTCGTGGTATGAAAGAAGAAGAAATGCGTGAAGTTGCTAAATTCCTGGCTAAAGTTCTGCTGAAAAAAGAAAACCCGACCAAAATCAAAGCTGAAGTTAAAGAACTGCTGATGGACTTCTCTCTGTTCCCGCTGGCTTACTCTTTCGACTTCCTGGTTGACGACGACCTGGGTAAATCTCTGCTGATGGAAGTTCTGTCTAAAT[0084]MKFDETKNNLIENNYSLFDELSGLFAIDFNYRQNTLSLTASENYPSLFVRILGSALCGGFYYFDPPYKADPGEWFFPDSGIMDAVAEKLKTLGSVLFEGQTFDWRPNGGSSAEQAVLLGICERGDGFVHFAHKDGGHFGLEELAKKIGINIYHFPMIEKTLLIDVERLKIMIQDHPDIKLVIFDQSFKLRWQPILKISEELPDIITLSYDCSHDGGLIAGNLFPQPLCQGIHILHGNTHKTIPGPQKGFISFADQNHPRLASVSNWVCPYMQSNSHAELIAPMLIAFSELAYFGKNYAKQITKNAKAFAIALAAEGFFVSGESFGYTETHQVHLILGSKEKSLNLVSSLLPEAGIRVNNVEIPGSNGSFGLRFGTQAMTRRGMKEDDFQEVARILSDLILKNKSPLEVRYEVREMLKKFLLFPLKYSFDDLLYNELGNQLLREVL[0086]MLSLTDIEDSPTEVSKMESVCDALAADFSRDNCYRSAHLSMTASENYPSKFVRAMGGAMQGAFYEFAPPYSTA__EGEWHFPDSGAQAALVQKLAQLGCQMFQAQTFDWRPNGGAAAEQAVLLGTCSRGDAFVHFGHQDGGHSSLEELARKIGIGIFHIPVQEDSLLIDVQRLAELLAAQPEIKLVILDQSFKLRWQPLAEIREIMPPTVTLAYDASHDGGLILGGVLPQPLAAGADIVLGNTHKTIPGPQKGYVAFFNARHPVLKPVSDWICPYMQSNSHAELLVPFYMALVEISLFGRPYAQQIVKNAKALALCMHAEGLRVVGESFGYTETHQVLVSIGSPGEALHAAAHLLALAGIRCNNIEIPGSGGRHGLRFGVQALTRRGIQEIDMAVIARFIARVLVRKEPPELVRNEVALFLRSFPLHPLAFSLDSQYEEPHAIRLR[0088]MRVAEQDRGAGPKPEAVGLEAVEAEVEAIVEDAAGAEGVWADDRVAQVLERLASDFVLDNTYREQHLSLTASENYPSKLVRMLGAGLQGGFYEFAPPYPAEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGSCGRGDGFVHFAHKDGGHFALESLAGAAGINTYHLPMVDRTLLIDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQIRAALPEGVFLAYDASHDGALIAGGALPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDAEHPKLKAVSDWVCPQMQSNSHAELIAPMYVALSEVALYGHAYARQILANAQALAHGLHEEGVRVSGESFGFTETHQVHVVTGSAADALRLSLGELARAGIRTTNIEVPGANGLHGLRLGVQAMTRRGLREPQMREVARLVAKVVLRRAEPAAVRAEVADLLQHHPLDRLAYSFDSYVDSPAAARLLGEVF[0090]MRVAEQDRGAGPKAEAAAVEVEAEAIVEDAAGAEGVWVDDRVAQVLERLASDFVLDNTYREQHLSLTASENYPSKLVRMLGAGLQGGFYEFAPPYPAEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGSCGRGDGFVHFAHKDGGHFALESLAGAAGINTYHLPMVDRTLLIDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQIRAALPAGVFLAYDASHDGALIAGGALPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDAEHPKLKAVSDWVCPQMQSNSHAELIAPMYVALSEVALYGHAYARQILANAQALAHGLHEEGLRVSGESFGFTETHQVHVVTGSAADALRLSLGELARAGIRTTNIEVPGANGLHGLRLGVQAMTRRGLREPQMREVARLVAKVVLRRAEPAAVRAEVADLLQHHPLDRLAYSFDSYVDSPAAARL[0092]MRVAEQDRGAGPKPEAVGLEAVEAEVEAIVEDVAGAEGVWAGDRVAQVLERLASDFVLDNTYREQHLSLTASENYPSKLVRMLGAGLQGGFYEFAPPYPAEAGEWAFPDSGANASLVGKLTGIGRQLFEAATFDWRPNGGSVAEQAVLLGTCGRGDGFVHFAHKDGGHFALESLAGAAGVNTYHLPMVDRTLLIDVDRLATLCAEHPEIKLVILDQSFKLRWQPLAQIRAALPEGVFLAYDASHDGALIAGGVLPQPTLLGADAVHGNTHKTIAGPQKAYIAFRDAEHPKLRAVSDWVCPQMQSNSHAELIAPMYVA