8-9-Dehydro-7-9-diisobutyryloxythymol-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE8,9-Dehydro-7,9-diisobutyryloxythymolCat.No.:HY-N13838CASNo.:22518-03-2分⼦式:C₁₈H₂₄O₅分⼦量:320.38作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性8,9-Dehydro-7,9-diisobutyryloxythymolThymol(HY-N6810)衍⽣的抗剂，能够从Ageratinaadenophora的地上部分分离得。8,9-Dehydro-7,9-diisobutyryloxythymol对蜡样芽孢杆具有选择性活性；同时，对⼈癌细胞系⽆体外可检测的细胞毒性活性。8,9-Dehydro-7,9-diisobutyryloxythymol可⽤于细感染的研究[1]。体外研究8,9-Dehydro-7,9-diisobutyryloxythymol(compound2)(1.0mg/mLinitialconcentrationwithserialdoublingdilution;5-6h)selectivelyexhibitsantibacterialactivityagainstB.cereuswithaMICof62.5μg/mLandnoactivityagainstS.aureus,B.thuringiensis,E.coli,orS.enterica[1].8,9-Dehydro-7,9-diisobutyryloxythymol(compound2)(1.5625-50μg/mL;3days)doesnotexhibitcytotoxicactivityagainstMCF-7,NCI-H460,orHeLacelllines[1].CellCytotoxicityAssay[1]CellLine:MCF-7,NCI-H460,HeLaConcentration:1.5625-50μg/mLIncubationTime:3daysResult:Detectednoobviouscytotoxicactivity;RecordedIC50>100μMagainstMCF-7,NCI-H460,andHeLacelllines.REFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].ZhangM,etal.ThymolderivativeswithantibacterialandcytotoxicactivityfromtheaerialpartsofAgeratinaadenophora.RSCAdv.2021Feb2;11(10):5755-5761McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>