免疫学-Antigen-抗原

1、Medical Immunology,吉林大学基础医学院免疫学教研室,1,Overview of Immunology,Organs and tissues Cells Molecules Antibodies Complement Cytokines MHC molecules,Antigen (Ag) Immune Responses Innate IR Adaptive IR Control mechanisms,Hypersensitivity Autoimmune disease Immunodeficiency Tumor immunology Transplantation re

2、jection,Components of IS,Functions of IS,Pathology of IR,* IS: Immune system IR: Immune response,2020/9/12,吉林大学基础医学院免疫学教研室,2,Functions of immune system (Consequences of IR - Physiology),Immunological defense Immunological homeostasis Immunological surveillance,Medical Immunology,吉林大学基础医学院免疫学教研室,3,Mi

3、crobes and worms. Inflammatory or died self-cells. Tumour cells.,Antigens,2020/9/12,吉林大学基础医学院免疫学教研室,4,Antigen ( Ag ),Term Fetuses,Medical Immunology,吉林大学基础医学院免疫学教研室,5,Ag,APCs,Th1,Tc,B,Ab,PMN,NK,Th2,Complement,Immune Response (IR),Target cells,MHC CK,MHC CK,CKs,CKs,Medical Immunology,吉林大学基础医学院免疫学教研室,

4、6,Term,Antibody + generator Antigen Ag Ab Ag Ab/T cells Ag IS IR,Medical Immunology,吉林大学基础医学院免疫学教研室,7,Features of Ag,Immunogenicity:Ag Ab / T cellsImmunoreactivity (Specificity):Ag + Ab Ag + T cells,Medical Immunology,吉林大学基础医学院免疫学教研室,8,Factors for immunogenicity,Ag itself Host conditions Adjuvant,Ag

5、 Ab / T cells,Medical Immunology,吉林大学基础医学院免疫学教研室,9,Ag itself,1. Non-self/changed self 2. Chemical nature - Proteins - Carbohydrates - Lipids - Nucleic acid 3. Molecular weight 4. Degradation 5. Dose,Medical Immunology,吉林大学基础医学院免疫学教研室,10,Medical Immunology,吉林大学基础医学院免疫学教研室,11,Medical Immunology,吉林大学基础

6、医学院免疫学教研室,12,Host conditions,1. Heredity: MHC 2. Route: - Subcutaneous（+） - Blood stream（+） - Gastrointestinal（+/-） - Respiratory（+/-）,Medical Immunology,吉林大学基础医学院免疫学教研室,13,Adjuvant,1. Properties: Promote the immunogenicity 2. Includes: - Mineral oil - Mineral salt - Bacteria - Cytokines 3. Mechanis

7、ms: - Enable Ag to be released slowly - Active APC - Induce cytotoxicity - Produce high affinity IR,Medical Immunology,吉林大学基础医学院免疫学教研室,14,Features of Ag,Immunogenicity:Ag Ab / T cellsReactivity (Specificity):Ag + Ab Ag + T cells,Medical Immunology,吉林大学基础医学院免疫学教研室,15,Epitope (antigenic determinant),F

8、actors for reactivity,Ag + Ab Ag + T cells,Medical Immunology,吉林大学基础医学院免疫学教研室,16,Medical Immunology,吉林大学基础医学院免疫学教研室,17,MHC I,MHC II,Medical Immunology,吉林大学基础医学院免疫学教研室,18,Antigens and epitope,Medical Immunology,吉林大学基础医学院免疫学教研室,19,Antigens and epitope,Medical Immunology,吉林大学基础医学院免疫学教研室,20,2020/9/12,吉林大学基础医学院免疫学教研室,21,Epitope (antigenic determinant) Linear epitope: -Epitopes formed by several adjacent amino acid residues. -For T cell recognition. Conformational epitope: - Epitopes f