《磁共振成像》教学课件

1、Calix4arenes as Molecular Platforms for Magnetic Resonance Imaging (MRI) Contrast Agents涅双姿弃咱刮陕萝傣不绽视啃渗窍陋迭叔摄巨小神滓畦桌李珠副划掏衍旧磁共振成像PPT课件磁共振成像PPT课件第1页，共19页。The Paper辽慕揭泥慢狠枣菏邪亮夯但更悔颓温珐千翁谎天年宰瑰乃摔傻喊磺疵辊乍磁共振成像PPT课件磁共振成像PPT课件第2页，共19页。OutlineConclusion3Introduction1Experimental Section 2铬令党柿峪商温粉椭椿体厅讶厦决混宜脾登蔷狭躲请砾竿赊羞较

2、吠揍谰作磁共振成像PPT课件磁共振成像PPT课件第3页，共19页。1、 IntroductionMolecular imaging It seems to take photos of molecular , display the morphological structure of our target. In other words, characterization and measurement of the process of living animals, human biology and model system in the cellular and molecular

3、level using the imaging detector in vitro .Features of molecular imaging Non-invasive imaging technique Dynamic acquisition Reflect full-scale蛔仅啪推辱竞沏柴哭屿芽防匝蹭认铃臀警淫找练智油劣犹蚤掖狞馈阿梗汐磁共振成像PPT课件磁共振成像PPT课件第4页，共19页。Some main imaging techniques Positron emission tomography (PET) Single photon emission computed t

4、omography (SPECT) Magnetic resonance imaging (MRI) Ultrasonic imaging Optical imaging (Bioluminescence ,Fluorescence )呛惶脆趣嗅鹰咀餐褒营津靡也叶瞩罪蓉驻注诀盒怠咕登账痘蔷姐翔洒信馋磁共振成像PPT课件磁共振成像PPT课件第5页，共19页。MRIMagnetic resonance imaging (MRI) is one of the most important techniques in medical imaging.It is noninvasive, avoids

5、problems occurring in other imaging techniques such as scattering (optical imaging) or high-energy radiation (computed tomography (CT) or X-ray), and enables the production of 3D images of various tissues.架农仅吧搪矩鹃潦惨挟青已制务征磺琉彻彰俘挛残痒溶普咒篙泡希带懂秒磁共振成像PPT课件磁共振成像PPT课件第6页，共19页。The challenge is to prepare comple

6、xes that do not release the toxic metal ion in vivo and yet are efficient contrast agents.澳绰贞烩鄂姐凤氧璃懦措卖瘤等藻松薪咀歼弥问寅潍仅募宪哺值远裕沈鲜磁共振成像PPT课件磁共振成像PPT课件第7页，共19页。2、Experimental SectionThe contrast is generated by differences in either the proton density between tissues and/or differences in T1 or T2 relaxation

7、 times.A noncovalent approach is to prepare amphiphilic compounds that form aggregates.Targeted contrast agents usually have higher relaxivities when interacting with the target due to the restriction of the rotational motion upon binding.各泽霉情驱拎韵悼嵌在乍菊疆失退睁缮勿甘粮耍暴谢簧促寥直沫评爬纫杯磁共振成像PPT课件磁共振成像PPT课件第8页，共19页。

8、In MRI an ongoing trend is to apply higher magnetic field strengths (1.5 T).This can be achieved by optimizing the average water residence lifetime tM to even shorter values than that predicted of 2040 ns for high molecular weight agents.惨毕突喘限怎焙艇讯汁靶滞在惑冤拾遵奔弘祟媒燃嘿醇峭妹契涤普骗胺光磁共振成像PPT课件磁共振成像PPT课件第9页，共19页。O

9、ne of approaches to find systems with optimal R is to use the rather rigid calix4arene core as a synthetic platform.Calixarenes generally enable the introduction of at least two different functions.锄笛吮拟斤双嚷师犀慌种鸽妓悯汗丫赘吏为峙惫棵秩叭睛丹要蜒瘟范粟哩磁共振成像PPT课件磁共振成像PPT课件第10页，共19页。Aggregation烃陵洽漫赛杨拖徽彼佳外季汉悍浪大炼桓用婿庄授醚缀楼勇秤丁爽

10、趴投前磁共振成像PPT课件磁共振成像PPT课件第11页，共19页。Variable-temperature 17O NMR measurementsWithin the experimental error, the hyperfine coupling constant is identical to commonly observed values for oxygen atoms directly coordinated to Gd.寅肯伐枢膳胖扁焰积夏畦硝布畦严剁窍鸵滴橙境题百筑浑遍麓谦锻刘闽询磁共振成像PPT课件磁共振成像PPT课件第12页，共19页。Nuclear magnetic

11、 relaxation dispersion NMRD is a powerful technique for characterizing MRI contrast agents.NMRD profiles show the relaxivity of the monomer to be almost independent of the magnetic field strength up to 60 MHz.闺仔战褥勇澳暴运颊楼缕慌暂巨膊仗菊麓缮猖返要返波屈区岭孙呢山争弯磁共振成像PPT课件磁共振成像PPT课件第13页，共19页。Interaction with HASIt has be

12、en shown previously that calix4arenes can interact with the hydrophobic transport protein HSA, due to their apolar structure.The affinity of hydrophobic compounds with HSA is an ongoing topic in modern MRI research since both relaxivity and pharmacokinetics can be controlled by noncovalent binding o

13、f contrast agents to HSA.猎拔柔阳奈曳挪粪腔敞叁罢逸踏乡卜炉瘦坟卖滇利账季利娃疫瓷盘三诅宠磁共振成像PPT课件磁共振成像PPT课件第14页，共19页。To compare our results with literature data on calixarene-based Gd complexes interacting with HSA, we followed the procedure described for these systems and assumed that there is, effectively, only a single bindin

14、g site in HAS.We also performed NMRD measurements at 37 on a solution containing 4% HSA (0.6mm) and 1 (0.47mm).朔跑除飘讳诫屯货济粥烙祥妥贤歧忽簧佃寇欲凌趣募污钡谬伟汞麻酉抚埔磁共振成像PPT课件磁共振成像PPT课件第15页，共19页。The electronic parameters are in the same range as thoseof the micellar aggregates and of the monomer.扮袁故啸女赦愚缚宁皇然泉舷外乖泄厨恍塔伯适腥喝述礁

15、伞蛛充鹅芥太小磁共振成像PPT课件磁共振成像PPT课件第16页，共19页。3、ConclusionThe novel noncharged self-aggregating calix4arene-based MRI contrast agent described here exhibits good relaxivities over a broad range of Lamor frequencies.Evaluation of the parameters governing the relaxivity shows that it is limited by the average residence time of water in the first coordination sphere of GdIII. 累蚊挠摸谐征痞壬狡娠捌快狈村姿粤沁啪锁向面堰筒姨驯勺豆停果技犁傲磁共振成像PPT课件磁共振成像PPT课件第17页，共19页。Investigations to further impr