肿瘤干细胞-课件（PPT演示）

肿瘤干细胞肿瘤干细胞Cancer Stem Cell Pluripotent 2. 成体干细胞成体干细胞 (somatic stem cell, adult stem cell, ASC);3. 骨髓干细胞骨髓干细胞 (bone marrow derived stem cell, BMSC)或造血干细胞或造血干细胞 (hematopoietic stem cell， HSC)n 根据干细胞的发育潜能分为三类：根据干细胞的发育潜能分为三类：1. 全能干细胞全能干细胞 (totipotent stem cell,TSC)、2. 多能干细胞（多能干细胞（ pluripotent stem cell）3. 单能干细胞（单能干细胞（ unipotent stem cell）。）。Hui H et al: Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas. 2010 Apr;39(3):315-22.Induced differentiation of human ESYderived cells in cultureDisappearance of stem cell markers and appearance of pancreatic A-cell markers during the human embryonic cell differentiationHui H et al: Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas. 2010 Apr;39(3):315-22.Expression of hedgehog signal molecules during the human embryonic cell differentiation.Hui H et al: Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas. 2010 Apr;39(3):315-22.干细胞起源？干细胞起源？体细胞克隆和干细胞克隆体细胞克隆和干细胞克隆体细胞克隆即取出一个双倍体细胞核移入一个去核的卵细胞，并在一定条件下进行核卵重组，再植入代孕母体中发育成新个体的过程。供体细胞均来自高度分化的体细胞，其种类繁多、数量无限。 。 克隆人类胚胎则是将卵细胞的遗传物质取出，只留下卵细胞中具有激发胚胎生长能力的细胞胞浆，然后将外源供者成熟体细胞的注入卵子。这种结合了 “外来 ”