肺肉瘤样癌ppt课件

PULMONARY SARCOMATOID CARCINOMA 1 Sarcomatoid carcinoma (SC) is a rare form of malignant tumor with cancer and sarcoma cells mixed .Its occur in many parts of the body, common in the upper respiratory tract, lung, breast and kidney. Pulmonary sarcomatoid carcinoma is a kind of Poorly differentiation non-small cell lung cancer . 2 Pathological characteristics. There are five subtypes: pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma and pulmonary blastoma Histologically, there were two kinds component epithelial and sarcomatoid mesenchymal tissue. sarcomatoid tissue is more important part. According to the histological characteristics, it can be divided into one-way sarcomatoid carcinoma and two-way. sarcomatoid carcinoma 3 The majority of SC is consisted of epithelial components and pleomorphic spindle like cells and / or giant cells . squamous cell carcinoma is more common epithelial component , followed by adenocarcinoma and large cell carcinoma, small cell carcinoma is rare. 4 SC is consided as epithelial tumors,sarcoma cells have highly expression rate in epithelial markers immunohistochemical features cancer component cells CK, EMA is positive , sarcomatoid component cells Vimetin is positive and most of them express CK, EMA and so on 5 clinical manifestations Cough bloody sputum shortness of breath, chest pain refractory pneumonia 6 CT image characteristic is atypical 7 Treatment surgery chemotherapy 8 prognosis and expectation Tumor 50mm, lymph node negative, no parietal pleural metastasis, no vascular invasion, and non squamous cell carcinoma components had better outcomes some studies have shown that pulmonary sarcomatoid carcinoma is easy to transfer may be associated with vascular invasion,c-MET m