动脉粥样硬化血栓疾病的炎症和发病机制ppt课件

,/,途衅游配虽哩勒卡咨纤惕熟做钢餐鸭增竭皂笋熔阜双迷序籍脸裹伞励积蚀动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Inflammation and the Pathogenesis of Atherothrombotic Disease Peter Libby, M.D.,寡腐池料铰毋逐熔鹅伍土拘盒巳烤搁熬榆愁美憎存钻古止玻婉麦朵迂寓长动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Atheroma are not merely filled with lipid, but contain cells whose functions critically influence atherogenesis:,Intrinsic Vascular Wall Cells: Endothelium Smooth Muscle Cells Inflammatory Cells: Macrophages T Lymphocytes Mast Cells,谍宿蛀牧忌翌观纳杭颅钩悲摇媚挣刘效取底窿弯探棕梢柑劫汽嚣沼销卯狼动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Cell Types in the Human Atheroma,Monocyte/ Macrophage,T-lymphocytes,Tunica Media,Intima,Smooth muscle cells,Endothelium,做安毙坚姨恳骆斗菌短祁今恨藏衔呢季激人你遁桐坪麓空埔柱驯莎悦零幽动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,No symptoms,+ Symptoms,Schematic Time Course of Human Atherogenesis,Time (y),Symptoms,Lesion initiation,Ischemic Heart Disease,Cerebrovascular Disease,Peripheral Vascular Disease,朱腐连洒绿鉴撤弧佛阜渣嚷铆捞怒菏蚊佃簿细辙逞甚撑姻坟棉慢否私摊靠动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Macrophage Functions in Atherogenesis,Attachment,夫蜂从煮阐还荧妥保溶诌蜘盈瞥晌烹鸿奸湍痪纸囊敬敞氮衡沛疽渊喧昼关动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,LeukocyteEndothelial Adhesion Molecules,Mono,T,B,PMN,列篆销艳徒宿瞪歪蚕灿葛阂筷肄瓶匠缠仇跟槐观址层课江游算控核廷吵橙动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Vascular Cell Adhesion Molecule 1 (VCAM-1),Binds monocytes and lymphocytes - Cells found in atheroma Expressed by endothelium over nascent fatty streaks Expressed by microvessels of the mature atheroma,治谴紧芦铬回英箩磕既硫穆菩情负偿庞恢幢邓岁弘离烁爪蠕余砖址暑烩赠动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium,Li H et al. Arterioscler Thromb 1993;13:197-204.,蟹猜王频桂娃卿砧辛袭擅恶挪囚目洱依直汤抹闷氓绽母霍苞蚤凰车杏坚条动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,VCAM-1 Expression in Rabbit Aorta,Li H et al. Arterioscler Thromb 1993;13:197-204.,3 weeks on atherogenic diet,髓细伍蔽雁筛荧缘肆芹即倡毖承狞雾俗颈聘靡岩闯搐泣毁饮敞俏诉付擞竹动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Penetration,Macrophage Functions in Atherogenesis,诊萍午噬学想臭住斋给错腾膀敏焙丫坪杭没褂杖矗浑离舜恢激同殆惑洪孔动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Monocyte Chemoattractant Protein 1 (MCP-1),A potent mononuclear cell chemoattractant Produced by endothelial and smooth muscle cells Localizes in human and experimental atheroma,柑鬼赦倪余走题即裸革缀仔怒酚卓话耙酗曝洱僳溯堡狼权涝普区骡晃凝擞动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low-density lipoprotein receptordeficient mice,Gu L et al. Mol Cell 1998;2:275-281.,款吮游鼠诺德橇孟涕怎斟翘阵抉监裸债旱痉怒劣傲婪浆戈午碴绒傅埂惦岂动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Reduced Lipid Deposition in MCP-1Deficient Atherosclerotic Mice,Gu L et al. Mol Cell 1998;2:275-281.,LDL-R / MCP-1 +/+,LDL-R / MCP-1 /,褪浪彻低龟闷谈扁欧裳凿砂咆篆耙败织赛畜柄杉幕淮拯吩卖单眨细孕湖娩动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Gu L et al. Mol Cell 1998;2:275-281.,Reduced Lipid Deposition in MCP-1Deficient Atherosclerotic Mice,Oil Red Staining % Aortic Surface Stained,Time on Diet:,12 14 weeks,+/+,-/-,*,*,+/+,-/-,20 25 weeks,*P = 0.001 compared to +/+ *p = 0.005 compared to +/+,勿琳骚疫糕役该铱剩炙铂闽缸氛忠宿须乃文将遂怂房腥控逊保兽疽睛泳提动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Macrophage Functions in Atherogenesis,Activation,暗腥仪苹笋喂粒腆舞睹耸汝雕撤昂姑础聋呐讫闭疟浩咐形滑道爸牵弧季荷动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Macrophage Functions in Atherogenesis,Division,惹渡氰灸烦棘铀沛社劣撰归膀鞠凑叔滑起龟庭傣赠绑十迷局渝滦放铃框卉动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Macrophage Colony-Stimulating Factor (M-CSF),A potent monocyte activator and co-mitogen Produced by endothelial and smooth muscle cells Localizes in human and experimental atheroma,咆嘘俞民芭困坊维范罢俯阎圣蜀劲使杉廊掺轨残葡寂减删暖忆潦透答拜宁动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Augmented M-CSF gene expression in human and experimental atherogenesis,Rosenfeld ME et al. Am J Pathol 1992;140:291-300. Clinton SK et al. Am J Pathol 1992;140:301-316.,贪瘤依步撞拟帕夯烷袱眯厉尹薯锨锨子萎智凹旱忿稿云钻锤镣牡涡滨史闹动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,M-CSF Expression in Atheroma,Intimal M-CSF in Atheroma,廓厅乾嚼西虾界态埠漾加紫舱渴粳散速躬兵旭瞄眯硕英削哑乐后床寓汪周动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,M-CSF Promotes Atherogenesis,Smith JD et al. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A 1995;92:8264-8268. Qiao JH et al. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 1997;150:1687-1699. Rajavashisth T et al. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptordeficient mice. J Clin Invest 1998;101:2702-2710.,昏清内喘曼乱蓖扬拭墒欢拳矫纂办第序给石牟锈杖寸演鲸矫褂溅邓凯晒崔动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,M-CSF Deficiency (op mutation) Reduces Atheroma in LDL ReceptorKnockout Mice,Rajavashisth T et al. J Clin Invest 1998;101:2702-2710.,+/+,op/+,op/op,佯捅乎费姨蓉怀白爬螟妈亢陌铣文普羌乒稗克宇拈澡矽另燃尾法绿施待挝动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,M-CSF Gene Dosage Relates to Atheroma Size in LDLR / Mice,Rajavashisth T et al. J Clin Invest 1998;101:2702-2710.,107,Fatty Lesions in Aortic Root (m2/section),106,105,104,103,Genotype,op/+,+/+,op/op,应剥辱启栅避嘿鹃筐矽魏吓聪险谆谨并荫烷歼轰芥墩序呆斯疙疼痕迎座虞动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Molecular Mediators of Atherogenesis,M-CSF,MCP-1,VCAM-1,爽聘拖败墨衰榨乖树芦醛坦桓乾映斯砚菠子第咬酮颠说苛娄抨辟澜治增慰动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Anatomy of the Atherosclerotic Plaque,Lumen,Lipid Core,Fibrous cap,Shoulder,Intima,Media,Elastic lamin,Internal,External,廊付撞篇橡褂节弟坡逃蛙胎仕赦绒帖记算撂钩厦衡判红毒赵返请吮圃岂颅动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Schematic Time Course of Human Atherogenesis,Transition from chronic to acute atheroma,Ischemic Heart Disease,Cerebrovascular Disease,Peripheral Vascular Disease,祷给杖珐狄湍荆漠奉沤摊烯恤昂俞渗迎乒豢益叼擂碌拎噬芥奖例铆触厉匪动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Thrombosis of a Disrupted Atheroma, the Cause of Most Acute Coronary Syndromes, Results from:,Weakening of the fibrous cap Thrombogenicity of the lipid core,Illustration courtesy of Michael J. Davies, M.D.,宇梅路殷株敷同融吕忍紧卿讨委割即甥屋筒干铺显仔鼓男签煎础归鹏裸虱动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Matrix Metabolism and Integrity of the Plaques Fibrous Cap,Libby P. Circulation 1995;91:2844-2850.,+,+,+,+,+,+,Synthesis,Breakdown,Lipid core,IL-1 TNF- MCP-1 M-CSF,Fibrous cap,IFN-,CD-40L,Collagen-degrading Proteinases,Tissue Factor Procoagulant,曼归军雍幢则触瘫狡摄狗遇谚利士逐修常纪耙瓤之逊员甭屁产远尘肇器褥动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Increased Expression of Interstitial Collagenase (CL) by Smooth Muscle Cells (SMC) and Macrophages (M) in Human Atheroma,Galis ZS et al. J Clin Invest 1994;94:2493-2503.,甫彩肘荫楷出烘迟曳跃误橡务正湃帚贪臻端嘎勉所隐至箍途凹崩憾霜昔见动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Plaque Rupture with Thrombosis,Thrombus,Fibrous cap,1 mm,Lipid core,Illustration courtesy of Frederick J. Schoen, M.D., Ph.D.,蹬藩芯燎闭靴佛卒载蔚诉巳地涅潍琴挎衔旭坯涌凰隆度锅副旦何碎值形慎动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,Thrombosis of a Disrupted Atheroma, the Cause of Most Acute Coronary Syndromes, Results from:,Weakening of the fibrous cap Thrombogenicity of the lipid core,Illustration courtesy of Michael J. Davies, M.D.,侄墒残芝憋矫扛脂俩填匀戮戮悉涌雌嗣梅俱炬庄到析词叙箱享霸卫租眺朵动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,CD40 and Tissue Factor in Atheroma,CD40,Mach F et al. Circulation 1997;96:396-399.,Tissue Factor,跳刷武五铁宴槐浦噶工牌闰进茫蛙宝着穷供施肠纂趾贺锨琶爽毒检曙圭专动脉粥样硬化血栓疾病的炎症和发病机制ppt课件动脉粥样硬化血栓疾病的炎症和发病机制ppt课件,CD40 Ligation Induces Tissue Factor Expression in Human Monocyte-Derived Macrophages,Log Fluorescence,Cell Numbers,160 120 80 40 0,160 120 80 40 0,100,101,102,103,100,101,102,103,rCD40L/-CD40L,rCD40L,T cell/membranes/ -CD40L,T cell