免疫球蛋白的同种型和同种异型课件

Immunoglobulin: Isotypes, Allotypes and Idiotypes,Immunoglobulin Isotypes,Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chains,Human IgM,antiserum,Reacts with IgM, IgG, IgA, IgD, IgE,React with IgG, IgA, IgD and IgE,Absorbed antiserum,Reacts only with IgM,Recognizes determinants specific for heavy chains (isotypes),Immunoglobulin Isotypes,?,?,?,Immunoglobulin Isotypes,Occurrence Importance Ig levels B cell tumors Immunodeficiencies,Definition,Location,Immunoglobulin Allotypes,Definition - Antigenic determinants specified by allelic forms of the Ig genes,Location,Occurrence,Source of anti-allotypic Abs,Human Immunoglobulin Allotypes,Nomenclature G1m(3) Km(1),Human Immunoglobulin Allotypes,Genetics (alleles) Co-dominant autosomal genes,Km(1)/Km(3) X Km(1)/Km(1),Km(1)/Km(1) and Km(1)/Km(3),Allelic exclusion,Genetics (pseudoalleles) Co-dominant,G1m(17),G1m(1),214,355-358,Human Immunoglobulin Allotypes,Immunoglobulin Allotypes,Definition Location Occurrence Importance Monitoring bone marrow grafts Forensic medicine Paternity testing,Immunoglobulin Idiotypes,Definition - Unique antigenic determinants present on individual antibody molecules or on molecules of identical specificity,DNP-BSA,Strain A Mouse,Anti-DNP Ab,Purified anti-DNP Ab,Strain A Mouse,Ab against combining site of anti-DNP Ab,?,Immunoglobulin Idiotypes,Immunoglobulin Idiotypes,Definition Location,Immunoglobulin Idiotypes,Definition Location Importance V region marker Regulation of immune responses,Ag,Id,anti-Id,+,-,anti-anti-Id,+,-,Regulation by Id/anti-Id,Immunoglobulin Idiotypes,Definition Location Importance V region marker Regulation of immune responses Vaccines,Anti-Idiotype Vaccines,Immunoglobulin Idiotypes,Definition Location Importan