MOLECULARBIOLOGYPROGRAM：分子生物学计划.docx

MOLECULAR BIOLOGY PROGRAMUniversity of ColoradoAnschutz Medical CampusMS812212801 E. 17th Ave., Room 9113Aurora, CO 80045303-724-3245303-724-3247 (fax)/molecularbiologyProgram DirectorRobert Sclafani, Ph.D.Professor of Biochemistry & Molecular GeneticsRC-1 South, Room 9100303-724-3271Student AdvisorSandy Martin, Ph.D.Professor of Cell & Development BiologyRC-1 South, Room 12116303-724-3467Program AdministratorSabrena HeilmanMolecular Biology Program OfficeRC-1 South, Room 9113303-724-3245Web Site: /molecularbiology Disclaimer for Student HandbookThis handbook, which includes parts of the Graduate School Rules and the Molecular Biology Program Guidelines, does not constitute a contract with the University of Colorado Denver Graduate School, either expressed or implied. The Molecular Biology Program reserves the right at any time to change, delete, or add to any of the provisions at its sole discretion. Furthermore, the provisions of this document are designed by the Program to serve as firm guidelines rather than absolute rules, and exceptions may be made on the basis of extenuating circumstances.TABLE OF CONTENTS2013-2014 Academic Calendar3UCD Graduate School & Campus Contact Numbers.4Membership Roster for Molecular Biology Program.5Molecular Biology Faculty Research Interests.7Academic Information.12Curriculum for Molecular Biology Students.13Financial Support.14Molecular Biology Program By-Laws.15Molecular Biology Student Guidelines19Graduate Student Expectations.26Guidelines for Choosing Students to be Supported by NIH Training Grant27Policy for Vacation and Leave. 28Conflict of Interest Policy 29Procedures for Changing Thesis Advisors and Dismissal from Thesis Lab.30Guidelines for Thesis Advisory Committee, Comprehensive Exam, and Thesis Defense.31Advice from those whove been there!.36UCD-AMC GRADUATE SCHOOLDeans OfficeBarry Shur, Ph.D., Dean303-724-2911Milinda Walker, Administrative Assistant303-724-2911Graduate Student Affairs OfficeFran Osterberg, M.S., Director, Student Admissions and Support303-724-2915Teresa Bauer-Sogi, Administrative Assistant/Main Phone Line for Information303-724-2915Jim Finster, Director of Academic Support Services303-724-2913OTHER IMPORTANT NUMBERS EMERGENCY NUMBERSAdmissions and Records(Diana Warren)303-724-8056EmergencyNon-emergency911303-724-4444Bookstore303-724-2665Bursars Office303-724-8032Classroom Scheduling303-724-8114Audio-Visual Assistance303-724-8129Diversity Office303-724-8003E-mail Coordinator303-724-2129E-mail Help Desk303-724-2171Police Escort to Car 303-724-4444Financial Aid303-556-2886Health Services/Insurance(LaVerne Loechel)303-724-7674ID Cards303-724-0399Health Sciences Library 303-724-2152Ombuds Office303-724-2950Parking Office303-724-0049Student Assistance Office303-724-7684Student Psychiatric Health Services/Counseling303-724-4953Emergency Dept.303-848-9111Information Systems303-724-4357Env. Health & Safety303-724-0345MOLECULAR BIOLOGY PROGRAM Faculty MembersMembersDeptTelMailRoomAnderson, StevePath437428104S-5110Appel, BrucePeds4434658108S-12115Artinger, KristinCraniofacial Bio445628120S-11112Barton, DavidMicro442158333N-9116Bayer, UlliPharm436108303N-6105Bentley, DavidBMG432388101S-10105Bradford, Andrew*OB-GYN435078309N-5100Britt, StevenCDB434418108S-12100Churchill, MairPharm436708303S-6113Colgan, SeanMed/Gastro47235B146RC2-10025Davis, RichardBMG432268101S-10109DeGregori, JamesBMG432308101S-9103Eisenmesser, ElanBMG432458101S-9117Evans, ThomasC DB434148108S-12104Ford, HeidePharm435098303N-6115Friedman, JamesOphthal466828311N-5106Graham, DouglasPeds440068302N-4101Gutierrez-Hartmann, AMedicine/Endo439608106S-7108Hagman, JamesImmun./NJC398-1398A-004K516BHesselberth, JayBMG453848101S-10104Holers, MichaelRheum/Immun47605B115M20-3201Holmes, Kathryn*Micro442318333N-9117Holmes, RandallMicro442238333N-9106Hooper, Joan*C DB434178108S-12103Hu, Cheng-JunCraniofacial Bio445768120S-11103Huang, MingxiaBMG432048101S-10112Jackson, TwilaOB-GYN435088309N-5112Johnson, AaronBMG432248101S-10116Johnston, MarkBMG432038101S-10100Jones, DavidPharm436018303S-6116Kieft, JeffreyBMG432578101S-9110Kutateladze, TatianaPharm435938303S-6112Liu, ChangweiBMG432088101S-9104Maller, James *Pharm416238303S-10122Martin, Sandy C DB434678108S-12116McManaman, JamesOB-GYN435008309N-5104McMurray, MichaelCDB465698108S-12117Megee, PaulBMG432708101S-10119Niswander, LeePeds437908133S-12106Nordeen, Steve Path443018104S-5117Pearson, ChadCCB457428108S-12110Prekeris, RytisCDB434118108S-12112Pyeon, DohunMicro472798333N-9120Reis, TniaMed/Endo431188106S-7122Reyland, MaryCraniofacial Bio445728120S-11113Roop, DennisDermatology430428320N-8129Schaack, JeromeMicro442208333N-9113Sclafani, Robert BMG432718101S-9100Thorburn, AndrewPharm432908303S-6100Tucker, ChandraPharm463378303S-6113VanDyk, LindaMicro442078333N-9114Vasil, Michael Micro442288333N-9127Vzquez-Torres, AndrsMicro442188333N-9131Voskuil, MartinMicro442198333N-9115Wang, JingImmuno303-398-1287A-004NJH K718Wang, Xiao-JingPath430018104N-5128Williams, TrevorCraniofacial Bio445718120S-11111Zhao, RuiBMG432698101S-9108* = non-training/emeritus faculty membersAdministrative StaffJames DeGregori, Director 43230 (S-9103)Jennifer Miller, Program Administrator 43245 (S-9113)MOLECULAR BIOLOGY TRAINING FACULTYRESEARCH INTERESTSSteven Anderson, Ph.D. (Dept. of Pathology) Signal transduction by cytokine receptors, breast cancer.303-724-3742, Bruce Appel, Ph.D. (Department of Pediatrics) Development and repair of the vertebrate nervous system.303-724-3465, Kristin Artinger, Ph.D. (Dept. of Craniofacial Biology)Molecular, genetic, and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis.303-724-4562, David Barton, Ph.D. (Dept. of Microbiology) Enterovirus RNA replication.303-724-4215, Ulli Bayer, Ph.D. (Dept. of Pharmacology) Molecular memory mechanisms in cellular signal transduction and neuronal function: CaMKII and Ca2+ signaling. 303-724-3610, David Bentley, Ph.D. (Dept. of Biochemistry & Molecular Genetics) mRNA biogenesis.303-724-3238, Andrew Bradford, Ph.D. (Dept. of Obstetrics & Gynecology) Hormone/growth factor signaling, and the regulation of gene transcription.303-724-3507, Steven Britt, M.D. (Dept. of Cell & Developmental Biology) Visual system development and function using molecular-genetic approaches in Drosophila.303-724-3441, Mair E.A. Churchill, Ph.D. (Dept. of Pharmacology) Structure and mechanism in gene regulation; biophysical and structural studies of protein-nucleic acid and protein-protein complexes in chromatin and bacterial pathogenesis.303-724-3670, Sean Colgan, Ph.D. (Dept. of Medicine/Gastroenterology) Understanding how epithelial and endothelial cells coordinate inflammatory bowel disease.303-724-7235, Richard Davis, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Spliced leader RNA trans-splicing and its role in post-transcriptional gene expression. Structure/function of mRNA cap-interacting proteins. 303-724-3226, James DeGregori, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Leukemogenesis and leukemia therapeutics.303-724-3230, Elan Eisenmesser, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Viral protein/host protein interactions, enzyme dynamics, and ligand/receptor interactions involved in cancer progression.303-724-9117, Thomas Evans, Ph.D. (Dept. of Cell & Developmental Biology) The control of embryonic polarity.303-724-3414, Heide Ford, Ph.D. (Dept. of Pharmacology) Parallels between normal development and tumorigenesis, homeoproteins, breast and ovarian cancers, Wilms tumor, metastasis.303-724-3509, James Friedman, Ph.D. (Dept. of Ophthalmology)Causes of retinal degenerative diseases, such as retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), which are a leading cause of inherited blindness. 303-724-6682, Douglas Graham, M.D./Ph.D. (Dept. of Pediatrics)TAM family of Receptor Tyrosine Kinases (RTKs) and how these RTKs contribute to the development and progression of human cancer.303-724-4006, Arthur Gutierrez-Hartmann, M.D. (Dept. of Medicine/Endocrinology) Elucidating the molecular mechanisms governing pituitary-specific gene expression. Determining the role of Ets transcription factors in breast cancer.303-724-3921, James Hagman, Ph.D. (Dept. of Immunology) Molecular regulation of B-cell development; transcription factor structure/function; epigenetic regulation of gene expression; oncogenesis in B-cells.303-398-1398, Jay Hesselberth, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Genomics of gene regulation.303-724-5384, V. Michael Holers, M.D. (Dept. of Rheumatology/Immunology) Structure-function of complement receptors; etiopathogenesis of autoimmune disease.303-315-7592, Randall K. Holmes, M.D./Ph.D. (Dept. of Microbiology) Molecular characterization of bacterial toxins gene regulation in pathogenic bacteria vaccine development.303-724-4223, Cheng-Jun Hu, Ph.D. (Dept. of Craniofacial Biology) Role of hypoxia response in tumor progression and metastasis.303-724-4576, Mingxia Huang, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Cell cycle and DNA damage checkpoint.303-724-3204, Twila Jackson, Ph.D. (Dept. of OB-GYN) Estrogen actions, endometrial cancer.303-724-3508, Aaron Johnson, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Mechanisms of chromatin-mediated gene silencing.303-724-3224, Mark Johnston, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Functional genomics, glucose sensing and signaling.303-724-3203, David Jones, Ph.D. (Dept. of Pharmacology) Molecular mechanism of alcohol and anesthetic actions; structure and function of biomolecules; NMR spectroscopy, x-ray crystallography, biophysics and molecular biology.303-724-3601, Jeffrey Kieft, Ph.D. (Dept. of Biochemistry & Molecular Genetics)RNA structure and function.303-724-3257, Tatiana Kutateladze, Ph.D. (Dept. of Pharmacology) Biochemistry and structural biology, NMR and crystal structures of proteins implicated in cancer; structure based drug design.303-724-3593, Changwei Liu, Ph.D. (Dept. of Biochemistry & Molecular Genetics) The ubiquitin proteasome pathway for protein degradation.303-724-3208, Sandra L. Martin, Ph.D. (Dept. of Cell & Developmental Biology) Molecular evolutionary genetics.303-724-3467, James McManaman, Ph.D. (Dept. of Physiology) Lactation, lipid secretion.303-724-3500, Michael McMurray, Ph.D. (Dept. of Cell & Developmental Biology) Mechanisms of assembly and inheritance of dynamic macromolecular structures: higher-order septin assemblies in budding yeast.303-724-6569, Paul Megee, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Molecular basis of sister chromatid cohesion.303-724-3270, Lee Niswander, Ph.D. (Dept. of Pediatrics) Genetics of mouse embryonic development focused on limb and lung development and neural tube closure.303-724-3790, Steven K. Nordeen, Ph.D. (Dept. of Pathology) Molecular mechanisms of steroid receptor mediated regulation of gene expression. Regulation of oncogene and mammary tumor virus transcription.303-724-4301, Chad Pearson, Ph.D. (Dept. of Cellular & Structural Biology) Centriole assembly and function303-724-5742, Rytis Prekeris, Ph.D. (Dept. of Cellular & Structural Biology) Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons.303-724-3411, Dohun Pyeon, Ph.D. (Dept. of Microbiology) Understanding how HPV (human papillomaviruses) interacts with the host factors to establish persistent infection and develop invasive cancers.303-724-7279, Tnia Reis, Ph.D. (Dept. of Medicine/Endocrinology) Genetic basis of obesity and neuronal control of energy balance in Drosophila melanogaster.303-724-3118, Mary Reyland, Ph.D. (Dept. of Craniofacial Biology) Regulation of apoptosis in epithelial cells by signal transduction pathways.303-724-4572, Dennis Roop, Ph.D. (Dept. of Dermatology) Skin development and disease.303-724-3042, Jerome Schaack, Ph.D. (Dept. of Microbiology) Adenovirus vectors.303-724-4220, Robert A. Sclafani, Ph.D. (Dept. of Biochemistry & Molecular Genetics) The regulation of the eukaryotic cell cycle; cell cycle regulation in yeast and human cancer cells.303-724-3271, Andrew Thorburn, Ph.D. (Dept. of Pharmacology) Understanding the signaling mechanisms that control apoptosis in cancer development and during the response of tumor cells to cancer therapeutics.303-724-3290, Chandra Tucker, Ph.D. (Dept. of Pharmacology) Study and manipulation of protein homeostasis and signaling pathways in live cells, optogenetic tools for controlling protein interactions, synthetic biology, cytosolic protein misfolding, yeast genetics/genomics.303-724-6337, Linda vanDyk, Ph.D. (Dept. of Microbiology) Virus/host interactions in inflammatory disease and cancer.303-724-4207, Michael L. Vasil, Ph.D. (Dept. of Microbiology) Molecular mechanisms of bacterial pathogenesis and gene regulation in prokaryotes, including Mycobacteria tuberculosis and Pseudomonas aeruginosa.303-724-4228, Andrs Vzquez-Torres, D.V.M./Ph.D. (Dept. of Microbiology) Understanding the role that mononuclear phagocytes play in the host response to intracellular pathogenic microorganisms.303-724-4218, Martin Voskuil, Ph.D. (Dept. of Microbiology)Mycobacterium tuberculosis and Burkholderia pseudomallei mechanisms of latency and drug tolerance.303-724-4219, Jing Wang, Ph.D. (Dept. of Immunology) Genomic instability and cancer development;metastasis and genomic instability; molecular mechanisms of somatic hypermutation and class switch recombination.303-398-1287, Xiao-Jing Wang, Ph.D. (Dept. of Pathology) Head and neck cancer research303-724-3001, XJ. Trevor Williams, Ph.D. (Dept. of Craniofacial Biology) Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer.303-724-4571, Rui Zhao, Ph.D. (Dept. of Biochemistry & Molecular Genetics) Molecular mechanism of pre-mRNA splicing; drug discovery.303-724-3269, ACADEMIC INFORMATIONIn-state Residency StatusNew students must immediately obtain documentation to support the petition for State Residency. This is a very important priority for first year students. After the first full year, only in-state tuition will be covered (assuming satisfactory academic progress), which requires that the student qualifies as an in-state resident.* The documents that must be obtained include local checking account, drivers license or State ID, and voters registration, as well as proof of Colorado domicile. Further information will be provided during the Graduate School Orientation. Checking AccountIt is important to establish a checking account as soon as possible. The University issues all pay checks, includ