冠心病英文版（888）.ppt

Atherosclerosis & Coronary heart diseases,Zhengzhou University, First affiliated Hospital Dept. of Cardiology Haiyu Li, M.D.,1,冠心病知识,Cardiovascular Diseases,2,冠心病知识,Atherosclerosis,3,冠心病知识,leading cause of death and disability Common location: Coronary circulation: Proximal left anterior descending coronary artery(LAD) Proximal portion of renal arteries Extracranial circulation to the brain Carotid bifurcation,Atherosclerosis,4,冠心病知识,Coronary heart disease,atherosclerosis,Coronary stenosis,coronary spasm,Myocardial ischemia, anoxaemia,Coronary heart disease, CHD Ischemic heart disease,5,冠心病知识,Atherosclerosis Stable angina pectoris(SAP) Acute coronary syndrome Unstable angina(UAP) and non-STEMI (UA/NSTEMI) ST elevation myocardial infarction(STEMI),6,冠心病知识,Three fundamental biological processes of atherosclerosis,Accumulation of intimal cells: smooth muscle cells Macrophages T-lymphocytes Proliferated connective tissue matrix : collagen elastic fibers proteoglycans 3. Accumulation of lipid: cholesterol esters free cholesterol,7,冠心病知识,Hypothesis of lipoprotein infiltration Aggregation of platelets and thrombosis Clonal theory the response-to-injury hypothesis,Atherosclerosis-Hypothesis,8,冠心病知识,Response-to-injury,Atherosclerosis: hypothesis,High blood pressure,bacterium,virus,toxin,ox-LDL, immune factor,vasoactive substance endothelium damage and dysfunction (vasoactive substance, adhesion and aggregation of monocytes-foam cell, platelets) Lipidosis, growth factor, proliferation of smooth mucle cells, collagen, lipolytic enzyme,atherosclerosis,9,冠心病知识,Pathology and pathophysiology Fatty steak Fibrous plaque Complicated lesion,Atherosclerosis,10,冠心病知识,Initiation of Atherosclerosis,Fatty steak formation,11,冠心病知识,Initiation of Atherosclerosis,Fatty steak formation Lipoprotein oxidation Nonenzymatic glycation Leukocyte recruitment Foam cell formation,12,冠心病知识,Atheroma evolution: fibrous plaque,Atheroma evolution and complications,Vascular remodeling: compensatory enlargement,13,冠心病知识,Atheroma evolution: Involvement of arterial smooth-muscle cells Blood coagulation microvessels,Atheroma evolution and complications,14,冠心病知识,Complicated lesion: thrombosis,Atheroma evolution and complications,15,冠心病知识,Atheroma evolution and complications,Vulnerable plaque: Thin fibrous cap Relatively large lipid core High content of macrophages,Inflammatory mediators,16,冠心病知识,Intravascular ultrasound,17,冠心病知识,Classicification of atherosclerotic lesion using IVUS,18,冠心病知识,Clinicl stages and classification Absence of symptom or stage of delitescence ischemia necrosis(target organ ) fibrosis,Atherosclerosis,19,冠心病知识,General manifestation Aortic atherosclerosis Coronary artery atherosclerosis Cerebral atherosclerosis Mesenteric atherosclerosis Peripheral artery atherosclerosis,Atherosclerosis,clinical manifestation,20,冠心病知识,laboratory examination Lack of sensitive and specific methods for early diagnosis Dyslipidemia： X-ray：DSA show severity of stenosis Doppler ultrasound: blood flow radionuclide： detection of ischemia Echocardiogram： CHD ECG and stress test: CHD New techniques: intravascular ultrasound, angioscope CT, MRI,Atherosclerosis,21,冠心病知识,Risk factors and prevention,1.Lifestyle modification 2.Lipid disorders (Dyslipidemia): cholesterol screening in all 20yrs Elevated: cholesterol (Tc and LDL-c), TG, ApoB/ApoA,Lp(a), Low: HDL-c LDL lowering by HMG-CoA reductase(statins): cardiovascular events 30%，risk of MI 62% 3.Hypertension： 4.DM,Metabolic syndrome or insulin resistance syndrome: BP, BMI ,TG, serum insulin HDL-c,22,冠心病知识,Diabetes mellitus(DM): RR 1.9 for male, 3.3 for female more diffuse lesion. CAD equivalent 75-80% cause of death in adult DM are vascular diseases: CAD, cerebrovascular disease, or peripheral vascular disease,Risk factors and prevention,23,冠心病知识,7 years incidence of death/non-fatal MI (East West Study),* These patients had no history of myocardial infarction Haffner SM, et al. N Engl J Med. 1998;339:229234.,0,5,10,15,20,25,30,35,40,45,50,Events of MI in 7 years,No history of MI OMI No history of MI* OMI,non-diabetics diabetics n = 1373 n = 1059,P 0.001,P 0.001,4%,19%,20%,45%,DM: CAD equivalent,24,冠心病知识,5. Cigarette smoking：more thrombogenic 6. Family history：genetic factor 7. Aging：40yrs adults ，4/5 fatal myocardial infarction occured in patiens 65 yrs 8. Male gender/ postmenopausal state： male:female = 2：1, man develop CHD 10-15 yrs earlier than woman 9. alcohol 10. Others: diet,homocysteine, hemostatic factors inflammation/infection,Risk factors and prevention,25,冠心病知识,Drug therapy： anti-platelet： aspirin, clopidogrel, GPIIb/IIIa inhitibor, Dipyridamole, cilostazol Lipid-lowering,Risk factors and prevention,26,冠心病知识,HMG-CoA reductase inhibitors（statins） Atorvastatin,Fluvastatin,Lovastatin,Pravastatin,Simvastatin,Cerivastatin, Rosuvastatin： *elevation of aminopherase, rhabdomyolysis 2. Bile acid-binding Resins cholestyramine，colestipol 3. Nicotinic Acid： 4. Fibric acid derivatives（fibrates） Gemifibrozil, clofibrate, Fenofibrate 5. Cholesterol absorption inhibitors: ezetimibe 6. Probucol,Lipid-lowering drugs,27,冠心病知识,Prevention of CAD,A: aspirin,ACEI B: blood pressure, -blocker, C: cigarette smoking, Cholesterol D: diet, diabetes E: exercise, education,28,冠心病知识,Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults ATP III (adult treatment panel III) Circulation 2002 17/24: 3144-3373,Atherosclerosis,29,冠心病知识,Coronary heart disease (CHD),30,冠心病知识,Coronary heart disease (CHD),most common cause: obstruction of atheromatous plaque other causes: spasm arterial thrombi coronary emboli ostial narrowing due to luetic aortitis congenital abnormalities severe LV hypertrophy,31,冠心病知识,Factors effect myocardial oxygen supply and demand,Oxygen supply,Oxygen demand,Heart rate,Myocardial contractility,Systolic wall stress,oxygen carrying capacity of blood,Coronary blood flow,Vascular resistance,Extravascular compressive forces,autoregulation,Metabolic regulation,Humoral factor,Neural regulation,Duration of diastole,Pressure gradient,Endothelial control,32,冠心病知识,Coronary heart disease,Type： slient ischemia: delitescence： (ECG change) Angina pectoris： angina, caused by myocardial ischemia myocardial infarction：acute myocardial ischemic necrosis caused by the occlusion of coronary artery Ischemia cardiomyopathy (Heart failure and arrhythmia)： cardiac enlargement, heart failure, arrhythmia, caused by the myocardial fibrosis as the consequence of chronic mycardial ischemia Sudden death： sudden cardiac arrest caused by ventricular fibrillation/flutter,33,冠心病知识,Coronary heart disease (CHD),Type： slient ischemia: delitescence Angina pectoris： myocardial infarction： Ischemic cardiomyopathy (Heart failure and arrhythmia) Sudden death,34,冠心病知识,Acute Coronary Syndrome(ACS),Resting ischemia,Non-ST elevation,STelevation,Unstable angina,Non-Q wave AMI,Q wave AMI,*positive serum cardiac markers,*,*,*,*,#,# occasionally variant angina,35,冠心病知识,Stable angina pectoris (SAP),36,冠心病知识,definition: acute and transient myocardial ischemia and anoxaemia usually caused by coronary insufficiency during exertion or emotional stress Characteristics: paroxysmal precordial squeezing-like chest pain, behind the mid sternum， radiated to left shoulder and upper arm precipitated by stress or exertion duration:2-5min typically relieved rapidly by rest or nitrates,Stable angina pectoris,37,冠心病知识,Coronary stenosis (others:aortic valve disease, HOCM, MB) + Myocardial oxygen demand（HR X SBP）increased myocardial hypoxia acumulation of metabolic product, stimulate C1-5 nerve to cause the sensation of chest pain,Stable angina pectoris,mechanism,38,冠心病知识,in angiography Significant coronary lesion with diameter stenosis 70% in 75% pts No significant stenosis in about 5-10% pts, Ischemia may be related to coronary spasm or microvascular dysfunction.,Pathology,Stable angina pectoris,39,冠心病知识,pathophysiology,1.Metabolic and electrophysiology ATP reduced, accumulation of acid substances Dysfunction of iron pump (Na+-K+, and Na+-Ca+) Early depolarization (ST deviation) 2.LV function and hemodynamic situation LV contractility and speed, systolic BP, stroke volume, cardiac output decreased LVED pressure and volume,Stunning of myocardium,Stable angina pectoris,40,冠心病知识,symptom：chest pain or oppression location behind or slightly to the left of the mid sternum no definite borderline radiated to the left shoulder and upper arm Atypical location: lower jaw, the back of neck,Clinical manifestation,Stable angina pectoris,41,冠心病知识,chest pain characteristics： tightness, squeezing, burning, pressing, choking, bursting,rarely sharp, not spasmodic force the patient stop the activity till the symptom relieved precipitation exertion or emotional agitation。 duration： 35 mins pain relief: within several mins after rest or using nitroglycerin,Clinical manifestation,Stable angina pectoris,42,冠心病知识,Physical examination increased HR, elevated BP anxiety sweating occasionally gallop rhythm，transient systolic murmur,Clinical manifestation,Stable angina pectoris,43,冠心病知识,Laboratory,Stable angina pectoris,44,冠心病知识,Stress test,rest,Exerscise,Stable angina pectoris,45,冠心病知识,2.Echocardiography: 3. Radionuclide imaging assessment: TL201，Tc99m-sestamibi myocardial perfusion scintigraphy 4.X-ray of heart 5.coronary angiography：final diagnose 6.others: IVUS、intracoronary Doppler flow 、intracoronary pressure,Laboratory,Stable angina pectoris,46,冠心病知识,Coronary Angiography,47,冠心病知识,1.Cardiogenic pain：aortic dissection, HOCM, aortic stenosis 2.Respiratory：PE, pneumothorax, pleuritis 3.Gastrointestinal: gastro-esophageal diseases, Hiatal hernia, cholecystitis, peptic ulceration, pancreatitis 4.Neuromuscular/skeletal ：Tietze Syndrome (Costochondritis), intercostal neuralgia, Herpes zoster 5.Psychologic: anxiety, depression, panic attacks,Stable angina pectoris,Diagnosis,Chest pain, risk factors, ECG evidence of ischemia during chest pain, angiography,Differentiation,48,冠心病知识,Functional classification of SAP(CCS ) CCS I： no chest pain at ordinary activity. Angina at strenuous or rapid or prolonged exertion CCS II： Slight limitation of ordinary activity. Walking or climbing stairs rapidly, after meals, in cold, in wind. Walking more than 2 blocks,climbing more than stairs of 3rd floor. CCS III： Marked limitation of ordinary activity. Walking 1 to 2 blocks, climbing stairs of 3rd floor CCS IV：Inability to carry on any activity without discomfort anginal symdrome may be present at rest.,Stable angina pectoris,49,冠心病知识,General consideration： rest，avoid provocative factors , risk factors control 2. Drug therapy: prevent MI and death symptom relief and quality of life improvment 3. Coronary revascularization: percutaneous coronary intervention (PCI) Coronary artery bypass surgery (CABG) SVG, LIMA,Prevention and treatment,Stable angina pectoris,50,冠心病知识,antianginal and anti-ischemic therapy,Drug therapy,Oxygen supply,Oxygen demand,a.nitrates b.beta-adrenergic blockers c.Calcium antagonists d.Drugs improving metabolism,Stable angina pectoris,51,冠心病知识,Drug therapy,a.nitrates lower oxygen demand: decrease arteriolar and venous tone, reduce preload and afterload increase coronary supply: Coronary dilatation Nitroglycerin Isosorbide dinitrate isosorbide 5-mononitrate (long-acting nitrates),Stable angina pectoris,52,冠心病知识,b. blockers: reduce myocardial oxygen: reduce HR, myocardial contractility, BP,the LV wall stress Abslute contraindications： sever bradycardia: high-degree A-V block, SSS, severe unstable LV failure Relative contraindications: asthma and bronchospastic disease peripheral vascular disease 1-selective：metoprolol, atenolol, bisoprolol,Drug therapy,Stable angina pectoris,53,冠心病知识,c.Calcium antagonists： Increase oxygen supply: dilate resistance vessels, release spasm, improve microvascular function Decrease oxygen demand: negative inotropic effect, decrease BP Antiplatelet effect,d. Drugs improving metabolism： trimethazine（vasorel），selectively inhibit 3-KAT（3-酮酰辅酶A硫解酶），partly inhibit FA oxidation,Drug therapy,Stable angina pectoris,54,冠心病知识,prevent MI and death therapy a.antiplatelet angents： ASA，75-325mg/d clopidogrel; ticlopidine: ADP receptor- antagonists: Cilostazol: phosphodiesterase inhititor,50-100mg bid b. Lipid-lowering angents: statins c. Angiotesin-converting enzyme inhibitor (ACEI),Drug therapy,Stable angina pectoris,55,冠心病知识,stenting,Stable angina pectoris,56,冠心病知识,Unstable angina(UAP) and non-STEMI,57,冠心病知识,Resting ischemia,Non-ST elevation,STelevation,Unstable angina,Non-Q wave AMI,Q wave AMI,*positive serum cardiac markers,*,*,*,*,#,# occasionally variant angina,Acute Coronary Syndrome(ACS),58,冠心病知识,Pathophysiology of ACS,stable angina UAP&non-Q-w AMI Q-w AMI Angiographic thrombus 0-1% 75% 90% Increased FPA/TAT 0-5% 60-80% 80-90% Activated platelets 0-5% 70-80% 80-90% Acute coronary occlusion 0-1% 10-25% 90% mortality 1-2% 3-8% 6-15%,FPA：fibrinopeptide A TAT：thrombin-antithrombin complexes,UAP and non-STEMI,59,冠心病知识,Occuring at rest (or with mininal exertion): last 20 mins severe and of new-onset: within 1-2 months, CCS III Occuring with a deteriorative pattern: at least CCS III variant angina pectoris (Prinzmetal angina): transient ST elevation, caused by the coronary spasm,Definition,UAP and non-STEMI,Angina pectoris or equivalent ischemic discomfort with at least one of the three features,60,冠心病知识,Braunwald classification of unstable angina,Severity： Class I： New-onset, or accelerated severe angina no rest pain within 2 months Class II： Angina at rest, subacute angina at rest (within the preceding month but not within 48 h) Class III： Angina at rest, acute ( within the preceding 48 h),UAP and non-STEMI,61,冠心病知识,Braunwald classification of unstable angina,Clinical Circumstances Class A：Secondary UAP a clearly identified condition extrinsic to the coronary vascular bed that has intensified myocardial ischemia, e.g. anemia, hypotension, tachy-arrhythmia Class B：Primary unstable angina Class C：Post-infarction UAP (within 2 weeks of a documented MI),UAP and non-STEMI,62,冠心病知识,mechanism：,1.plaque rupture and erosion, with nonocclusive thrombus 2.dynamic obstruction: Vasoconstruction 3.progressive mechnial obstruction(rapidly advancing or ISR following stenting) 4.secondary UA Inflammation Thrombogenesis,UAP and non-STEMI,63,冠心病知识,ECG: Non-STEMI: ST depression last 12 hr,Cardiac biomarkers of myocardium damage: cTnT, cTnI CK-MB,UAP and non-STEMI,Coronary angiography Angioscopy and IVUS Other laboratory tests,64,冠心病知识,Risk stratification：TIMI Risk Score Age =65yrs More than 3 coronary risk factors Prior angiographic coronary obstruction ST-segment deviation 0.5 mm More than 2 angina events within 24 hours Development of UA/NSTEMI while on aspirin Elevated cardiac markers,Antaman, JAMA 2000; 284:835-42,TIMI IIB, ESSENCE, PRISM-PLUS,TACTICS-TIMI18,UAP and non-STEMI,65,冠心病知识,Treatment,1.Genearl management: rest, oxygen, CCU 2. Drug therapy A. Anti-ischemic drug: intravenously, orally nitrates -blocker Calcium antagnoist: first choice for variant angina Morphine,UAP and non-STEMI,66,冠心病知识,Treatment,2. Drug therapy: B. antithrombotic therapy a. Anti-platelet Aspirin: early, 300mg loading dose ADP-receptor antagonist: clopidogrel 300mg-600mg loading dose, 75 mg/d GP IIb/IIIa receptor inhibitor: used in pts planned to PCI b. Anticoagulation therapy: Heparin Low molecular weight heparin(LMWH) Direct anti-thrombin drug: bivalirudin, hirudin,UAP and non-STEMI,67,冠心病知识,Treatment,2. Drug therapy: C. other medical therapy a. lipid-lowering drugs: statins, early use(in first 24 hrs) LDL-c target: 70 mg/dl b. ACEI: long-term secondary prevention,UAP and non-STEMI,68,冠心病知识,Treatment,3. Invasive versus conservative strategy early invasive strategy indicated for high risk patients: within 48-72 hrs, Following by coronary revascularization(PCI or CABG) 4. Long-term management -blockers, Statin, ACEI,aspirin clopidegrel(12m),UAP and non-STEMI,69,冠心病知识,70,冠心病知识,SYMPTOMS SUGGESTIVE OF ACS,Noncardiac Diagnosis,Chronic Stable Angina,Possible ACS,Definite ACS,Treatment as indicated by alternative diagnosis,ACC/AHA Chronic Stable Angina Guidelines,No ST-Elevation,ST-Elevation,Nondiagnostic ECG Normal initial serum cardiac biomarkers,ST and/or T wave changes Ongoing pain Positive cardiac biomarkers Hemodynamic abnormalities,Evaluate for reperfusion therapy,ACC/AHA STEMI Guidelines,Observe 12 h from symptom onset,No recurrent pain; negative follow-up studies,Recurrent ischemic pain or positive follow-up studies Diagnosis of ACS confirmed,Stress study to provoke ischemia Consider evaluation of LV function if ischemia is present (tests may be performed either prior to discharge or as outpatient),Negative Potential diagnoses: nonischemic discomfort; low-risk ACS,Arrangements for outpatient follow-up,Positive Diagnosis of ACS confirmed or highly likely,Admit to hospital Manage via acute ischemia pathway,Algorithm for evaluation and management of patients suspected of having ACS. Anderson JL, et al. J Am Coll Cardiol 2007;50:e1e157, Figure 2.,71,冠心病知识,ST elevation myocardial infarction STEMI,72,冠心病知识,Acute Coronary Syndrome(ACS),Resting ischemia,Non-ST elevation,STelevation,Unstable angina,Non-Q wave AMI,Q wave AMI,*positive serum cardiac markers,*,*,*,*,#,# occasionally variant angina,73,冠心病知识,ischemic necrosis of myocardium results from the prolonged myocardial ischemia precipitated by an occlusive coronary thrombus at the site of a preexisting atherosclerotic plaque。 With typical and serial ECG changes,Represent the serious situation of coronary artery disease,STEMI,Definition,74,冠心病知识,1.incidence ：in USA, 71 in male between 35-84 yrs, 22 in female, 1 attack in about 20 second 2. mortality： decreased in 30% recent 10 years still 1/3 of the patients died 50%